1. Liu T, Liu X, Li W. Tetrandrine, a Chinese plant-derived alkaloid, is a potential candidate for cancer chemotherapy. Oncotarget 2016; 7(26): 40800–15.

2. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin 2021; 71(3): 209–49.

3. Farhood B, Geraily G, Alizadeh A. Incidence and mortality of various cancers in Iran and compare to other countries: A review article. Iran J Public Health 2018; 47(3): 309–16.

4. Fitzmaurice C, Akinyemiju TF, Al Lami FH, Alam T, Alizadeh-Navaei R, Allen C, et al. Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 29 cancer groups, 1990 to 2016 a systematic analysis for the global burden of disease study. JAMA Oncol 2018; 4(11): 1553–68.

5. Carvalho Â, Ferreira G, Seixas D, Guimarães-Teixeira C, Henrique R, Monteiro FJ, et al. Emerging lab-on-a-chip approaches for liquid biopsy in lung cancer: Status in ctcs and ctdna research and clinical validation. Cancers 2021; 13(9): 1-23.

6. Hirsch FR, Scagliotti G V., Mulshine JL, Kwon R, Curran WJ, Wu YL, et al. Lung cancer: current therapies and new targeted treatments. Lancet 2017; 389(10066): 299–311.

7. Lemjabbar-Alaoui H, Hassan OUI, Yang YW, Buchanan P. Lung cancer: Biology and treatment options. Biochim Biophys Acta - Rev Cancer 2015; 1856(2): 189–210.

8. Huang CY, Ju DT, Chang CF, Muralidhar Reddy P, Velmurugan BK. A review on the effects of current chemotherapy drugs and natural agents in treating non-small cell lung cancer. Biomed 2017; 7(4): 12–23.

9. Fennell DA, Summers Y, Cadranel J, Benepal T, Christoph DC, Lal R, et al. Cisplatin in the modern era: The backbone of first-line chemotherapy for non-small cell lung cancer. Cancer Treat Rev 2016; 44: 42–50.

10. Baharara J, Amini E, Nikdel N, Salek-Abdollahi F. The cytotoxicity of dacarbazine potentiated by sea cucumber saponin in resistant B16F10 melanoma cells through apoptosis induction. Avicenna J Med Biotechnol 2016; 8(3): 112–9.

11. Goldar S, Khaniani MS, Derakhshan SM, Baradaran B. Molecular mechanisms of apoptosis and roles in cancer development and treatment. Asian Pac J Cancer Prev 2015; 16(6): 2129–44.

12. Campbell KJ, Tait SWG. Targeting BCL-2 regulated apoptosis in cancer. Open Biol 2018; 8(5): 1–11.

13. Khalid EB, Ayman ELMELK, Rahman H, Abdelkarim G, Najda A. Natural products against cancer angiogenesis. Tumour Biol 2016; 37(11): 14513–36.

14. Zyad A, Tilaoui M, Jaafari A, Oukerrou MA, Mouse HA. More insights into the pharmacological effects of artemisinin. Phytother Res 2018; 32(2): 216–29.

15. Kooti W, Servatyari K, Behzadifar M, Asadi-Samani M, Sadeghi F, Nouri B, et al. Effective Medicinal Plant in Cancer Treatment, Part 2: Review Study. J Evid Based Complementary Altern Med 2017; 22(4): 982–95.

16. Kaur R, Arora S. Alkaloids- Important Therapeutic Secondary Metabolites of Plant Origin. J Crit Rev 2015; 2(3): 1–8.

17. Ortiz LMG, Lombardi P, Tillhon M, Scovassi AI. Berberine, an epiphany against cancer. Molecules 2014; 19(8): 12349–67.

18. Park KS, Kim J Bin, Bae J, Park SY, Jee HG, Lee KE, et al. Berberine inhibited the growth of thyroid cancer cell lines 8505C and TPC1. Yonsei Med J 2012; 53(2): 346–51.

19. Lin JF, Lin YC, Tsai TF, Chen HE, Chou KY, Hwang TIS. Cisplatin induces protective autophagy through activation of BECN1 in human bladder cancer cells. Drug Des Devel Ther 2017; 11: 1517–33.

20. Liu L, Sun L, Zheng J, Cui L. Berberine modulates Keratin 17 to inhibit cervical cancer cell viability and metastasis. J Recept Signal Transduct Res 2020; 0(0): 1–11.

21. Sani TA, Mohammadpour E, Mohammadi A, Memariani T, Yazdi MV, Rezaee R, et al. Cytotoxic and apoptogenic properties of Dracocephalum Kotschyi aerial part different fractions on calu-6 and mehr-80 lung cancer cell lines. Farmacia 2017; 65(2): 189–99.

22. Baharara J, Amini E, Afzali M, Nikdel N, Mostafapour A, Kerachian MA. Apoptosis inducing capacity of holothuria arenicola in CT26 colon carcinoma cells in vitro and in vivo. Iran J Basic Med Sci 2016; 19(4): 358–65.

23. Yu XJ, Sun K, Tang XH, Zhou CJ, Sun H, Yan Z, et al. Harmine combined with paclitaxel inhibits tumor proliferation and induces apoptosis through down-regulation of cyclooxygenase-2 expression in gastric cancer. Oncol Lett 2016; 12(2): 983–8.

24. Kumar S, Agnihotri N. Piperlongumine, a piper alkaloid targets Ras/PI3K/Akt/mTOR signaling axis to inhibit tumor cell growth and proliferation in DMH/DSS induced experimental colon cancer. Biomed Pharmacother 2019; 109: 1462–77.

25. Mousavi B, Tafvizi F, Zaker Bostanabad S. Green synthesis of silver nanoparticles using Artemisia turcomanica leaf extract and the study of anti-cancer effect and apoptosis induction on gastric cancer cell line (AGS). Artif Cells Nanomed Biotechnol 2018; 46(Sup1): 499–510.

26. Wu LW, Zhang JK, Rao M, Zhang ZY, Zhu HJ, Zhang C. Harmine suppresses the proliferation of pancreatic cancer cells and sensitizes pancreatic cancer to gemcitabine treatment. Onco Targets Ther 2019; 12: 4585–93.

27. Wang Y, Zhou M, Shang D. Berberine inhibits human gastric cancer cell growth via deactivation of p38/JNK pathway, induction of mitochondrial-mediated apoptosis, caspase activation and NF-κB inhibition. J BUON 2020; 25(1): 314–8.

28. Majidzadeh H, Araj-Khodaei M, Ghaffari M, Jafari A, Shanehbandi D, Torbati M, et al. The combination of berberine and methotrexate enhances anti-cancer effects in HeLa cancer cell line: A morphological study. Pharm Sci 2021; 27(4): 536-42.

29. Liu L, Fan J, Ai G, Liu J, Luo N, Li C, et al. Berberine in combination with cisplatin induces necroptosis and apoptosis in ovarian cancer cells. Biol Res 2019; 52(1): 1-14.

30. Mohiuddin M, Kasahara K. Cisplatin Activates the Growth Inhibitory Signaling Pathways by Enhancing the Production of Reactive Oxygen Species in Non-small Cell Lung Cancer Carrying an EGFR Exon 19 Deletion. Cancer Genomics Proteomics 2021; 18(3 Suppl): 471–86.

31. Zhu T, Li LL, Xiao GF, Luo QZ, Liu QZ, Yao KT, et al. Berberine Increases Doxorubicin Sensitivity by Suppressing STAT3 in Lung Cancer. Am J Chin Med 2015; 43(7):1487–502.

32. Chen J, Huang X, Tao C, Wang L, Chen Z, Li X, et al. Berberine chloride suppresses non-small cell lung cancer by deregulating Sin3A/TOP2B pathway in vitro and in vivo. Cancer Chemother Pharmacol 2020; 86(1): 151–61.

33. Kou Y, Tong B, Wu W, Liao X, Zhao M. Berberine Improves Chemo-Sensitivity to Cisplatin by Enhancing Cell Apoptosis and Repressing PI3K/AKT/mTOR Signaling Pathway in Gastric Cancer. Front Pharmacol 2020; 11(December):1–10.

34. Li Q, Zhao H, Chen W, Huang P. Berberine Induces Apoptosis and Arrests Cell Cycle in Multiple Cancer Cell lines. Arch Med Sci 2021; Articles in press.

35. Wang HY, Yu HZ, Huang SM, Zheng YL. P53, Bcl-2 and cox-2 are involved in berberine hydrochloride-induced apoptosis of HeLa229 cells. Mol Med Rep 2016; 14(4): 3855–61.