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Biochemistry and Nutrition in Metabolic Diseases
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The protective effect of Chia (Salvia hispanica) seed against Benzopyrene induced oxidative injuries in mice
Pourua Riazi , Maryam Karimi-Dehkordi , Mohsen Jafarian Dehkord
Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran , ma_karimivet58@yahoo.com
Abstract:   (135 Views)
Background: Benzopyrene is a known environmental carcinogen that causes oxidative stress, inflammation and other metabolic complications. In the present study, the therapeutic effects of chia seeds (Salvia hispanica) against oxidative damage caused by benzopyrene in laboratory mice were investigated.
Material and Methods: 55 male mice were divided into 11 groups. The 1-3th groups were used as negative control (normal food), olive oil (benzopyrene solvent) and positive control (benzopyrene), respectively. Benzopyrene was administered at a dose of 75 mg/kg body weight for 4 weeks through gavage with olive oil. The 4 and 5 groups were related to the use of vitamin E alone and with benzopyrene. Vitamin E was administered at a dose of 250 mg/kg by gavage or IP. The other three groups received chia seeds orally at doses of 10, 20 and 30% w/w, respectively. The three intervention groups were given chia seeds in high doses along with benzopyrene for 4 weeks.
Results: Administration of benzopyrene induces oxidative toxicity, which is evidenced by a significant decrease in TAC and SOD. These changes were significantly improved in the group treated with high doses of chia seeds. While the treatment with vitamin E was not able to correct the oxidative stress caused by benzopyrene.
Conclusion: These results showed that chia seeds, due to being rich in antioxidant compounds, have effective antioxidant properties that play an important role against the oxidative toxicity caused by benzopyrene, which can even work better than vitamin E in laboratory animals.
Keywords: Antioxidants, Benzo (a) pyrene, Chia seed, Mice, Oxidative Stress, Vitamin E
Type of Study: Research | Subject: General
Received: 2024/01/27 | Revised: 2024/06/23 | Accepted: 2024/06/23
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