1. Zierer J, Pallister T, Tsai PC, Krumsiek J, Bell JT, Lauc G, et al. Exploring the molecular basis of age-related disease comorbidities using a multi-omics graphical model. Sci Rep. 2016;6:37646. doi: 10.1038/srep37646. PMID: 27886242; PMCID: PMC5122881

2. Mitchell WK, Williams J, Atherton P, Larvin M, Lund J, Narici M. Sarcopenia, dynapenia, and the impact of advancing age on human skeletal muscle size and strength; a quantitative review. Front Physiol. 2012;3:260. doi: 10.3389/fphys.2012.00260. PMID: 22934016; PMCID: PMC3429036.

3. Csete ME. Basic Science of Frailty-Biological Mechanisms of Age-Related Sarcopenia. Anesth Analg. 2021; 132(2): 293-304. doi: 10.1213/ANE.0000000000005096. PMID: 32769382

4. Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, et al. Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019; 48(1): 16-31. doi: 10.1093/ageing/afy169. Erratum in: Age Ageing. 2019 ;48(4):601. PMID: 30312372; PMCID: PMC6322506

5. Kimball SR, Jefferson LS. Control of translation initiation through integration of signals generated by hormones, nutrients, and exercise. J Biol Chem. 2010; 285(38): 29027-32. doi: 10.1074/jbc.R110.137208. PMID: 20576612; PMCID: PMC2937931

6. You JS, Anderson GB, Dooley MS, Hornberger TA. The role of mTOR signaling in the regulation of protein synthesis and muscle mass during immobilization in mice. Dis Model Mech. 2015 Sep;8(9):1059-69. doi: 10.1242/dmm.019414. PMID: 26092121; PMCID: PMC4582099.

7. Sciarretta S, Volpe M, Sadoshima J. Mammalian target of rapamycin signaling in cardiac physiology and disease. Circ Res. 2014; 114(3): 549-64. doi: 10.1161/CIRCRESAHA.114.302022. PMID: 24481845; PMCID: PMC3995130

8. Saxton RA, Sabatini DM. mTOR Signaling in Growth, Metabolism, and Disease. Cell. 2017; 168(6): 960-76. doi: 10.1016/j.cell.2017.02.004. PMID: 28283069; PMCID: PMC5394987.

9. Vainshtein A, Sandri M. Signaling Pathways That Control Muscle Mass. Int J Mol Sci. 2020; 21(13):4759. doi: 10.3390/ijms21134759. PMID: 32635462; PMCID.

10. Avruch J, Long X, Lin Y, Ortiz-Vega S, Rapley J, Papageorgiou A, et al. Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor. Biochem Soc Trans. 2009;37(Pt 1):223-6. doi: 10.1042/BST0370223. PMID: 19143636.

11. Wang Y, Huang BP, Luciani DS, Wang X, Johnson JD, Proud CG. Rheb activates protein synthesis and growth in adult rat ventricular cardiomyocytes. J Mol Cell Cardiol. 2008; 45(6): 812-20. doi: 10.1016/j.yjmcc.2008.07.016. PMID: 18722381.

12. Makhnovskii PA, Zgoda VG, Bokov RO, Shagimardanova EI, Gazizova GR, Gusev OA, et al. Regulation of Proteins in Human Skeletal Muscle: The Role of Transcription. Sci Rep. 2020; 10(1): 3514. doi: 10.1038/s41598-020-60578-2. PMID: 32103137; PMCID: PMC7044165

13. Chen J, Zhou R, Feng Y, Cheng L. Molecular mechanisms of exercise contributing to tissue regeneration. Signal Transduct Target Ther. 2022; 7(1): 383. doi: 10.1038/s41392-022-01233-2. PMID: 36446784.

14. Phillips SM. Physiologic and molecular bases of muscle hypertrophy and atrophy: impact of resistance exercise on human skeletal muscle (protein and exercise dose effects). Appl Physiol Nutr Metab. 2009; 34(3): 403-10. doi: 10.1139/H09-042. PMID: 19448706.

15. Goodman CA, Frey JW, Mabrey DM, Jacobs BL, Lincoln HC, You JS, et al. The role of skeletal muscle mTOR in the regulation of mechanical load-induced growth. J Physiol. 2011;589(Pt 22): 5485-501. doi: 10.1113/jphysiol.2011.218255. PMID: 21946849; PMCID: PMC3240886.

16. Haraguchi FK, de Brito Magalhães CL, Neves LX, dos Santos RC, Pedrosa ML, Silva ME. Whey protein modifies gene expression related to protein metabolism affecting muscle weight in resistance-exercised rats. Nutrition. 2014;30(7-8): 876-81. doi: 10.1016/j.nut.2013.12.007. PMID: 24985006.

17. Chen LK, Woo J, Assantachai P, Auyeung TW, Chou MY, Iijima K, et al. Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment. J Am Med Dir Assoc. 2020; 21(3): 300-307.e2. doi: 10.1016/j.jamda.2019.12.012. PMID: 32033882

18. Karbasi S, Zaeemi M, Mohri M, Rashidlamir A, Moosavi Z. Effects of testosterone enanthate and resistance training on myocardium in Wistar rats; clinical and anatomical pathology. Andrologia. 2018; 50(3). doi: 10.1111/and.12908. PMID: 29047154.

19. Masoudian B, Azamian Jazi A, Faramarzi M, Talebi A. The effect of an 8-week resistance training on ActRIIβ in fast- and slow-twitch skeletal muscles and plasma levels of GDF8, GDF11 and GASP-1 in old male rats. RJMS 2019; 25(12):104-15 doi: 20.1001.1.22287043. 1397.25. 12.6.1

20. Braidy N, Poljak A, Grant R, Jayasena T, Mansour H, Chan-Ling T, et al. Differential expression of sirtuins in the aging rat brain. Front Cell Neurosci. 2015; 9: 167. doi: 10.3389/fncel.2015.00167. PMID: 26005404; PMCID: PMC4424846.

21. Sangdevini M, Fallah Mohammadi Z, Oladnabi M. Effect of 8 weeks of resistance training and concurrent resistance-aerobic training on phospho-mTOR and phospho-p70S6K responses in skeletal muscle of rat. J Gorgan Univ Med Sci 2020; 22(1):43-9.

22. Jacobs BL, You JS, Frey JW, Goodman CA, Gundermann DM, Hornberger TA. Eccentric contractions increase the phosphorylation of tuberous sclerosis complex-2 (TSC2) and alter the targeting of TSC2 and the mechanistic target of rapamycin to the lysosome. J Physiol. 2013; 591(18): 4611-20. doi: 10.1113/jphysiol. 2013. 256339. PMID: 23732640; PMCID: PMC3784202

23. Abou Sawan S, van Vliet S, Parel JT, Beals JW, Mazzulla M, West DWD, et al. Translocation and protein complex co-localization of mTOR is associated with postprandial myofibrillar protein synthesis at rest and after endurance exercise. Physiol Rep. 2018; 6(5): e13628. doi: 10.14814/phy2.13628. PMID: 29512299; PMCID: PMC5840389

24. Gonzalez AM, Hoffman JR, Stout JR, Fukuda DH, Willoughby DS. Intramuscular Anabolic Signaling and Endocrine Response Following Resistance Exercise: Implications for Muscle Hypertrophy. Sports Med. 2016; 46(5): 671-85. doi: 10.1007/s40279-015-0450-4. PMID: 26666743

25. Song Z, Moore DR, Hodson N, Ward C, Dent JR, O’Leary MF, et al. Resistance exercise initiates mechanistic target of rapamycin (mTOR) translocation and protein complex co-localisation in human skeletal muscle. Sci Rep 2017; 7:5028.

26. Fry CS, Drummond MJ, Glynn EL, Dickinson JM, Gundermann DM, Timmerman KL, et al. Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis. Skelet Muscle 2011; 1: 1-1.

27. Kumar V, Atherton PJ, Selby A, Rankin D, Williams J, Smith K, et al. Muscle protein synthetic responses to exercise: effects of age, volume, and intensity. J Gerontol A Biol Sci Med Sci. 2012; 67(11): 1170-7. doi: 10.1093/gerona/gls141. PMID: 22859389.

28. Breen L, Phillips SM. Skeletal muscle protein metabolism in the elderly: Interventions to counteract the 'anabolic resistance' of ageing. Nutr Metab (Lond). 2011; 8: 68. doi: 10.1186/1743-7075-8-68. PMID: 21975196; PMCID: PMC3201893.

29. Panwar V, Singh A, Bhatt M, Tonk RK, Azizov S, Raza AS, Sengupta S, Kumar D, Garg M. Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease. Signal Transduct Target Ther. 2023; 8(1): 375. doi: 10.1038/s41392-023-01608-z. PMID: 37779156

30. Miyazaki M, McCarthy JJ, Fedele MJ, Esser KA. Early activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide 3-kinase/Akt signalling. J Physiol. 2011; 589(Pt 7): 1831-46. doi: 10.1113/jphysiol.2011.205658. PMID: 21300751; PMCID: PMC3099033

31. Hundal HS, Taylor PM. Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling. Am J Physiol Endocrinol Metab. 2009; 296(4): E603-13. doi: 10.1152/ajpendo.91002.2008. PMID: 19158318; PMCID: PMC2670634

32. Lama-Sherpa TD, Jeong MH, Jewell JL. Regulation of mTORC1 by the Rag GTPases. Biochem Soc Trans. 2023;51(2):655-64. doi: 10.1042/BST20210038. PMID.

33. Li M, Verdijk LB, Sakamoto K, Ely B, van Loon LJ, Musi N. Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise. Mech Ageing Dev. 2012; 133(11-12): 655-64. doi: 10.1016/j.mad.2012.09.001. PMID: 23000302; PMCID: PMC3631591.

34. Bodine SC. The role of mTORC1 in the regulation of skeletal muscle mass. Fac Rev. 2022; 11: 32. doi: 10.12703/r/11-32. PMID: 36532707.

35. Watson K, Baar K. mTOR and the health benefits of exercise. Semin Cell Dev Biol. 2014; 36:130-9. doi: 10.1016/j.semcdb.2014.08.013. PMID: 25218794