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The effect of a period of swimming training with different temperatures on the expression of β3-AR and ERK2 genes in the visceral adipose tissue of streptozotocin-induced diabetic rats
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Kianoosh Mohammadi  , Ali Khajehlandi * |
| Department of Physical Education and Sport Sciences, Gachsaran Branch, Islamic Azad University, Gachsaran, I.R. Iran. , a.khajehlandi@yahoo.com |
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Abstract: (814 Views) |
Background: β3-AR and ERK2 are key factors in regulating adipose tissue metabolism and its conversion to brown adipose tissue. Therefore, the present study aimed to investigate the effect of a period of swimming training with different temperatures on the expression of β3-AR and ERK2 genes in the visceral adipose tissue of diabetic rats.
Materials and Methods: 28 male 2-month-old Wistar rats with a mean weight of 200±20 g were selected. After diabetic induction through streptozotocin solution, divided into 4 groups: 1) healthy control, 2) diabetic control, 3) diabetic water swimming training 5 °C and 4) diabetic water swimming training 36 °C (n=7 per each group) were divided. The training groups trained aerobic swimming training for 5 days/week for 4 weeks according to Protocol. One-way ANOVA and Tukey Post-hoc tests were used to analyze the data.
Results: A significant decrease in β3-AR gene expression was observed (P=0.0001), and the results showed that this difference was significant between pairs of healthy control groups compared to other groups (P=0.0001). Also, ERK2 gene expression showed a significant increase (P=0.0001), and the results showed that this is a significant difference between pairs of healthy control groups with water swimming training 36 °C (P=0.001) and diabetic control group with water swimming training 36 °C (P=0.001).
Conclusion: Four weeks of swimming training decreased β3-AR and increased ERK2, which can be concluded to play an important role in the metabolism of white adipose tissue and its conversion to brown adipose tissue.
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| Keywords: ERK2, Diabetes, Swimming training, Visceral adipose tissue, β3-AR |
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Full-Text [PDF 372 kb]
(473 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2021/07/5 | Accepted: 2021/10/31 | Published: 2022/02/1
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