[صفحه اصلی ]   [Archive] [ English ]  
:: صفحه اصلي :: درباره مجله :: شماره جاری :: تمام شماره‌ها :: جستجو :: ثبت نام :: ارسال مقاله :: تماس با ما ::
بخش‌های اصلی
صفحه اصلی::
اطلاعات نشریه::
بانک‌ها و نمایه‌ها::
آرشیو مجله و مقالات::
برای نویسندگان::
اخلاق در پژوهش::
برای داوران::
تسهیلات پایگاه::
تماس با ما::
::
Basic and Clinical Biochemistry and Nutrition
..
DOAJ
..
CINAHL
..
EBSCO
..
IMEMR
..
ISC
..
جستجو در پایگاه

جستجوی پیشرفته
..
دریافت اطلاعات پایگاه
نشانی پست الکترونیک خود را برای دریافت اطلاعات و اخبار پایگاه، در کادر زیر وارد کنید.
..
enamad
..
:: دوره 23، شماره 5 - ( دوماه نامه 1398 ) ::
جلد 23 شماره 5 صفحات 466-455 برگشت به فهرست نسخه ها
اثر عصاره ی هیدروالکلی تخم کدوتنبل بر میزان هورمون استروژن و مارکرهای کبدی موش های صحرایی ماده ی بالغ
سمانه معتمد جهرمی ، صادق نیامی جهرمی
دانشکده پزشکی، دانشگاه علوم پزشکی جهرم، مرکز مطالعات و توسعه آموزش علوم پزشکی بندرعباس، دانشگاه علوم پزشکی بندرعباس، بندرعباس، ایران ، sanammorsal400500@yahoo.com
چکیده:   (2849 مشاهده)
سابقه و هدف: استروژن مصنوعی اثرات مخربی بر بافت کبد می­ گذارد. به نظر می‌رسد تخم کدوتنبل بتواند جایگزین مناسبی در هورمون­ درمانی باشد. هدف از انجام این پژوهش بررسی تأثیر عصاره­ی هیدروالکلی تخم کدوتنبل بر میزان هورمون استروژن در موش‌های صحرایی ماده­ی بالغ و اثرات آن بر مارکرهای کبدی و تغییرات بافتی کبد و تخمدان می­ باشد.
مواد و روش ­ها: در این تحقیق تجربی 40 سر موش صحرایی­ ماده ­بالغ از نژاد ویستار (در محدوده­ ی وزنی10±180 گرم و سن 60 روز) انتخاب و به ­طور تصادفی به 5 گروه 8 تایی: سه گروه تجربی، کنترل و شاهد تقسیم شدند. به گروه­ های تجربی عصاره هیدروالکلی تخم کدوتنبل (با دوزهای 50،20 و100 میلی گرم بر کیلوگرم وزن بدن به ­ترتیب جهت گروه­ های تجربی 1، 2 و 3) به­ مدت 21 روز متوالی به‌صورت درون­ صفاقی تزریق شد. سپس سطح سرمی مارکرهای کبدی و تخمدانی تعیین و مطالعات بافت­ شناسی  بر روی کبد و تخمدان انجام شد.
نتایج: کاهش معنی­ دار در میزان سرمی ALP و افزایش معنی­ دار در میزان سرمی هورمون­ های استروژن و FSH وLH  و تعداد فولیکول‌های ­گراف در گروه ­تجربی 3 و کاهش معنی ­دار در تعداد فولیکول­ های بدوی و اوّلیه در هر سه گروه تجربی نسبت به گروه کنترل و کاهش معنی­ دار تعداد فولیکول­ های ثانویه در گروه ­تجربی 1 نسبت به گروه­ های تجربی 2 و 3 مشاهده شد (0/05>P).
نتیجه­ گیری: استروژن موجود در عصاره­ی هیدورالکلی تخم­ کدوتنبل بدون اثر مخرب بر بافت کبد می تواند مسیر تخمک­ گذاری را طی نماید و جایگزین مناسبی برای استروژن­ های مصنوعی و تنظیم­ کننده­ ی چرخه ­ی عادت­ ماهیانه زنان باشد.
واژه‌های کلیدی: استروژن، کبد، موش صحرایی، ماده، عصاره
متن کامل [PDF 535 kb]   (2640 دریافت)    
نوع مطالعه: پژوهشي | موضوع مقاله: عمومى
دریافت: 1397/7/2 | ویرایش نهایی: 1399/2/15 | پذیرش: 1398/5/26 | انتشار: 1398/9/25
فهرست منابع
1. Raphael K, Clive W, Amos M, Misheck M, Clarice N, Perkins M, et al. Proximate composition of pumpkin gourd (Cucurbita pepo) seeds from Zimbabwe. IJNFS 2014; 3(4): 279-83.
2. Mozaffarian v. Identification of Medicinal and Aromatic Plants of Iran. 5th ed. Tehran: Farhang Moaser Publisher; 2012. p. 1434-44.
3. Sohini R, Santa D. A comprehensive review of the versatile pumpkin seeds (Cucurbita maxima) as a valuable natural medicine. IJCR 2015; 7(8): 19355-61.
4. Devi NM, Prasad RV, Sagarik N. A review on health benefits and nutritional composition of pumpkin seeds. IJCS 2018; 6(3): 1154-7.
5. Maheshwari P, Prasad N, Batra E. Papitas -The Underutilized Byproduct and the Future Cash Crop- A Review. AIJRFANS 2015; 31-4.
6. Revathy MN, Sabitha N. Development, quality evaluation and popularization of pumpkin seed flour incorporated bakery products. IJFANS 2013; 2(2): 40-5.
7. Priyanka M, Neha P, Ekta B. Papitas-The Underutilized Byproduct and the Future Cash Crop- A Review. AIJRFANS 2015; 12(1): 31-4.
8. Moura FA, Spier F, Zavareze ER, Dias ARG, Elias MC. Biscoitos tipo “cookie” elaborados com diferentes frações de semente de abóbora (curcubita maxima). Alim. Nutr 2010; 21(4): 579-85.
9. Paucar-Menacho M.L, Salvador-Reyes R, Guillén-Sánchez J, MoriArismendi S. Effect of partial substitution of wheat flour by soybean meal in technological and sensory characteristics of cupcakes for children of school age. Scientia Agropecuaria 2016; 7(2): 121-32.
10. Batosta JER, Braja LP, Olivera RCd, Solva EP, Damoano C. Partial replacement of wheat flour by pumpkin seed flour in the production of cupcakes filled with carob, Food Sci. Technol 2018; 38(2): 250-4.
11. Montesano R, Blasi F, Simonetti MS, Santini A, Cossignani L. Chemical and Nutritional Characterization of Seed Oil from Cucurbita maxima L.(var. Berrettina) Pumpkin. Foods 2018; 7(30): 1-14.
12. Seif HSA. Ameliorative Effect of Pumpkin Oil (Cucurbita pepo L.) Against Alcohol-induced Hepatotoxicity and Oxidative Stress in Albino Rats. BJBAS 2014; 3(3): 178-85.
13. Elinge CM, Muhammad A, Atiku FA, Itodo AU, Peni IJ, Sanni OM, et al. Proximate, mineral and anti-nutrient composition of pumpkin (Cucurbita pepo L) seeds extract. J Plant 2012; 2(5): 146-50.
14. Y Al-Okbi S. Urgent Demand of the Continual Studies of Drug-Nutrition-Interrelation. RJPCS 2015; 6(1): 914-30.
15. Karanja JK, Mugendi BJ, Khamis FM, Muchugi AN. Nutritional composition of the pumpkin (cucurbita spp.) Seed cultivated from selected regions in kenya. J IJAF 2013; 3(1): 17-22.
16. Montesano D, Blasi F, Simonetti MS, Santin A, Cossignani L. Chemical and Nutritional Characterization of Seed Oil from Cucurbita maxima L. (var. Berrettina) Pumpkin, Foods 2018; 7(3): 30.
17. Gossell-Williams M, Davis A, O'Connor N. Inhibition of testosterone-induced hyperplasia of the prostate of sprague-dawley rats by pumpkin seed oil. JMF 2006; 9(2): 284-6.
18. Vahlensieck W, Theurer C, Pfitzer E, Patz B, Banik N, Engelmann U. Effects of Pumpkin Seed in Men with Lower Urinary Tract Symptoms due to Benign Prostatic Hyperplasia in the One-Year, Randomized, Placebo-Controlled GRANU Study. Urol Int 2015; 94: 286-95.
19. Tsai YS, Tong YC, Cheng JT, Lee CH, Yang FS, Lee HY. Pumpkin seed oil and phytosterol-f can block testosterone/prazosin-induced prostate growth in rats. Urol Int 2006; 77(3): 269-74.
20. Awad AB, Fink CS. Phytosterols as anticancer dietary components: evidence and mechanism of action. J Nutr 2000; 130(9): 2127–30.
21. Raicht RF, Cohen BI, Fazzini EP, Sarwal AN, Takahashi M. Protective effect of plant sterols against chemically induced colon tumors in rats. Cancer Res 1980; 40(2): 403-5.
22. Yadav M, Jain S, Tomar R, Prasad GB, Yadav H. Medicinal and biological potential of pumpkin: an updated review. Nutr Res Rev 2010; 23: 184-90.
23. Hernández-Santos B, Rodríguez-Miranda J, HermanLara E, Torruco-Uco JG, Carmona-García R, Juárez-Barrientos JM, et al. Effect of Oil Extraction Assisted by Ultrasound on The Physicochemical Properties and Fatty Acid Profile of Pumpkin Seed Oil (Cucurbita pepo). J.Ultsonch 2016; 31: 429–36.
24. Lestari B, Meiyanto E. A Review: The Emerging Nutraceutical Potential of Pumpkin Seeds. IJCC 2018; 9(2): 92-101.
25. Rabrenovic BB, Dimic EB, Novakovic MM, Tesevic VV, Basic ZN. The Most Important Bioactive Components of Cold Pressed Oil from Different Pumpkin (Cucurbita pepo L.) seeds, JLWT 2014; 55: 521–7.
26. Hickman Jr. Animal diversity. 7th ed. New York: McGraw-Hill; 2014. p. 500-12.
27. Gossell-Williams M, Hyde C, Hunter T, Simms-Stewart D, Fletcher H, McGrowder D, et al. AImprovement in HDL cholesterol in postmenopausal women supplemented with pumpkin seed oil: pilot study. Climacteric 2011; 14(5): 558-564.
28. Hall JE. Guyton and Hall textbook of medical physiology E-Book . 13th ed. New York: Saunders; 2015. P. 1120-72.
29. Barrett KE, Barman SM, Boitano S , Brooks HL. Ganong sReview of medical physiology. 25th ed. New York: McGraw-Hill; 2015. P. 760-8.
30. Wilson K, Walker J. Principles and Techniques of Biochemistry and Molecular Biology. 1th ed. Britain: Cambridge University Press; 2013. p. 328-744.
31. Cho Y, Ariga M, Uchijima Y, Kimura K, Rho J. Y, Furuhata Y, et al. The novel roles of liver for compensation of insulin resistance in human growth hormone transgenic rats. Endocrinology 2006; 147(11): 5374–84.
32. Jordan VC. Estrogen Action, Selective Estrogen Receptor Modulators and Women's Health: Progress and Promise. 1th ed. Londen: Imperial College Press; 2013. P. 501–44.
33. Kelce WR, Borgert CJ. In Vitro Detection of Estrogen Activity in Plastic Products Using a Sensitive Bioassay: Failure to Acknowledge Limitations. EHP 2011; 119(9): 378-9.
34. Caldwell SH, Hoffman M, Lisman T, Macik BG, Northup PG, Reddy KR, et al. Coagulation disorders and hemostasis in liver disease: pathophysiology and critical assessment of current management. Hepatology 2006; 44(4): 1039-46.
35. Mueller MN, Kappas A. Estrogen pharmacology. I. The influence of estradiol and estriol on hepatic disposal of sulfobromophthalein (BSP) in man. J Clin Invest 1964; 43(10): 1905-14.
36. Firpi RJ, Soldevila-Pico C, Abdelmalek MF, Morelli G, Judah J, Nelson DR. Short recovery time after percutaneous liver biopsy: should we change our current practices?. CG Hepatol 2005; 3: 926-9.
37. Zafari Zanganeh F. Reproduction system. Tehran: Tamirzadeh Cultural and Educational Institute. 2th ed. Iran:Tabriz Publication; 2008. P. 250-69.
38. Ben- ze’ev A, Amsterdam A. Regulation of cytoskeletal proteins involved in cell contact formation during differentiation of granulosa cells on extracellular matrix. PNAS 1986; 83(9): 2894-98.
39. Malter H, Talansky B, Gordon J, Cohen J. Monospermy and polyspermy after partial zona dissection of reinseminated human oocytes. MRD 1989; 23(4): 377-86.
40. Moore AA, Noonun MD. A Nurse's guide to hormone replaeement therapy. JOGNN 1996; 25(1): 24-31.
41. Erickson GF, Facua L, Shimaski S. Analysis of spatial and temporal expression patterns of bone morphogenetic protein family members in the rat uterus over the estrous cycle. J Endocrinol 2004; 182: 203-17.
42. Biuin W, Baker H. Biology of rat. 4th ed. NewYourk Led: NewYourk Academic; 1997. p. 110-120.
43. Harder JD. Mammalian reproduction II: estrous cylces, Gestaion & lactation, Zoology: EEOB. 2th ed. American: Pearson Benjamin Cummings; 2004. p. 625.
44. Jashni HK, Kargar H, Gorbani A, Karga Z, Khabaz Z. Effects of aqueous extract from Asparagus officinalis L. roots on hypothalamic-pituitary-gonadal axis hormone levels and the number of ovarian follicles in adult rats. Int J Reprod BioMed 2016; 14( 2): 75-80.
45. Castrodale D, Bierbaum O, Helwig EB and MacBryde CM. Comparative studies of the effects of estradiol and stilbesterol upon the blood, liver, and bone marrow. Endocrinology 1941; 29(3): 363-72.
46. Barros RP, Gustafsson JA. Estrogen receptors and the metabolic network. Cell Metab 2011; 14(3): 289–99.
47. Tan KT, Rajan DK, Kachura JR, Hayeems E, Simons ME, Ho CS. Pain after percutaneous liver biopsy for diffuse hepatic disease: a randomized trial comparing subcostal and intercostal approaches. JVIR 2005; 16: 1215-09.
48. Garber JC, Barbee RW, Bielitzki JT, Clayton LA, Donovan JC. Guide for the care and use of laboratory animals. 8th ed. Washington DC: The National Academies Press; 2011. p. 238-46.
49. Marianna N, Tzortzis N, Elizabeth F. Antioxidant and lipooxygenase inhibitory activities of pumpkin seed extracts. J.Foodres 2009; 42: 641-6.
50. Mathangi S. A study on extraction of oil from Pumpkin seed using sun drying and hot air oven dryin. IJFSN 2018; 3(1): 34-6.
51. Rozylo R, Gawlik-Dziki U, Dziki D, Jakubczik A, Karas M, Rozylo K. Wheat Bread with Pumpkin (Cucurbita maxima L.)Pulp as Functional Food. FTB 2014; 52(4): 430–8.
52. Poštić D, Nebojša M, Zoran B, Lana Đ, Ratibor Š, Terzić D, Stanisavljević R. The Effect Genotype and Ecological Conditions on Yield Components of Potato. JPEA 2017; 21(4): 207-21.
53. Srdić J, Milašinović-Šeremešić M, Radosavljević M, Kravić N, Babić V. Evaluation of agronomic and sensory characteristics of the popcorn kernel. JPEA 2017; 21(4): 185-7.
54. Czerny B, Pawlik A, Teister M, Juzyszyn Z, Mysliwiec Z. Effect of tamoxifen and raloxifene on cholesterol transformation to bile acids in ovariectomized rats. Gynecological Endocrinol 2005; 20(6): 313–06.
55. Dhiman RK, Chawla YK. Hormone Replacement Therapy and Gallstone Disease: A Real Association. Digeslion 2008; 77: 1–3.
56. Schoultz Bv , Carlström K, Collste L, Eriksson A, Henriksson P, Pousette A, Stege R. Estrogen therapy and liver function-metabolic effects of oral and parenteral administration. Prostat 1989; 14(4): 389–95.
57. Bataineh ZM, Hani IH, Al-Alami JR. Zinc in normal and pathological human prostate gland. Saudi Med J 2002; 23(2): 218-20.
58. Abbot DH ,Tarantalt AF, Dumesic DA. Fetal, infant, adolescent and adult phenotypes of polycystic ovary syndrome in prenatally androgenized female rhesus monkeys. Am J Primatol 2009; 71: 776–84.
59. John E. Text Book of physiology. 13th ed. United States: Surg Neurol Int; 2017. p. 1011-24.
60. Zamiri MJ. Reproductive physiology. Tehran: Haghshenas Publication; 2005. p. 430-48.
61. Fernández-Pérez L, Guerra B, C. Díaz-Chico J, Flores-Morales A. Estrogens Regulate the Hepatic Effects of Growth Hormone, a Hormonal Interplay with Multiple Fates. FENDO. 2013; 4: 66.
62. Gao H, Bryzgalova G, Hedman E, Khan A, Efendic S, Gustafsson JA, et al. Long-term administration of estradiol decreases expression of hepatic lipogenic genes and improves insulin sensitivity in ob/ob mice: a possible mechanism is through direct regulation of signal transducer and activator of transcription 3. Mol Endocrinol 2006; 20: 1287–99.
63. Baik M, Yu JH, Hennighausen L. Growth hormone-STAT5 regulation of growth, hepatocellular carcinoma, and liver metabolism. Ann N Y Acad Sci 2011; 1229: 29–37.
64. Chen Z, Wang Ou Nie M, Elison K, Zhou D, Li M, Jiang Y, et al. Aromatase deficiency in a Chinese adult man caused by novel compound heterozygous CYP19A1 mutations: Effects of estrogen replacement therapy on the bone, lipid, liver and glucose metabolism. J MCE 2015; 399: 32-42.
65. Eisalo A, Jarvinen PE, Luukkainen T. Hepatic impairment during the intake of contraceptive pills: Clinical trial with post menopausal women. Brit Med J 1964; 2(5406): 426- 7.
66. Barclay JL, Nelson CN, Ishikawa M, Murray LA, Kerr LM, McPhee TR, et al. GH-dependent STAT5 signaling plays an important role in hepatic lipid metabolism. Endocrinology 2011; 152: 181–92.
67. Hodges RM. The effects of oral estrogen-progestin compounds on blood coagulation factors. Int J Fertil 1968; 13: 349–53.
68. Bassuk SS, Manson JE. Oral contraceptives and menopausal hormone therapy: relative and attributable risks of cardiovascular disease, cancer, and other health outcomes. Ann Epidemiol 2015; 25(3): 193–200.
69. Barnes S. Phytoestrogens and osteoporosis- What is a safe dose?. Br J Nutr 2004; 89(51): S101-8.
70. The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Ferti Steri 2004; 81(1): 19-25.
71. Van-Erpecum KJ, Van-Berge-Henegouwen GP, Verschoor L, Stoelwinder B, Willekens FL. Different hepatobiliary effects of oral and transdermal estradiol in postmenopausal women. Gastroenterol 1991; 100: 482-8.
72. Czerny B, Pawlik A, Juzyszyn Z, Myśliwiec Z, Teister M. Effect of tamoxifen, raloxifen and tibolon on bile components in ovariectomized rats. Eur J Obstet Gynecol Reprod Biol 2005; 119(2): 194-7.
73. Rimington C, DeMatteis F. Oral contraceptives and acute intermittent porphyria. Lancet 1965; 1: 255-70.
74. Ginsburg J, Prelevic GM. Is there a proven place for phytoestrogens in the menopause?. Climacteric 1999; 2: 75-8.
75. Padhi EMT, Belewet HJ, Duncan AM, Gusman RP, Hawke A, Seetharaman K, et al. Whole Soy Flour Incorporated into a Muffin and Consumed at 2 Doses of Soy Protein Does Not Lower LDL Cholesterol in a Randomized, Double-Blind Controlled Trial of Hypercholesterolemic Adults. J Nutr 2015; 145(12): 266526-74.
76. Marion B, Rejeski J, Rudnick S, Bonkovsky HL. Porphyrias–An Overview and Update for Physicians and their Staffs. Medical Research Archives 2017; 5(9): 1-22.
77. Namavar Jahromi B, Parsanezhad ME, Shomali Z, Bakhshai P, Alborzi M, Moin Vaziri N, et al. Ovarian Hyperstimulation Syndrome: A Narrative Review of Its Pathophysiology, Risk Factors, Prevention, Classification, and Management. Iran J Med Sci 2018; 43(3):248-260.
78. Moreira P, Custódio J, Nunes E, Moreno A, Seiça R, Oliveira C, et al. Estradiol affects liver mitochondrial function in ovariectomized and tamoxifen-treated ovariectomized female rats. Toxicol Appl Pharmacol 2007; ‌221: 102–1.
79. Awad AB, Fink CS. Phytosterols as anticancer dietary components: evidence and mechanism of action. J Nutr 2000; 130(9): 2127-30.
ارسال پیام به نویسنده مسئول

ارسال نظر درباره این مقاله
نام کاربری یا پست الکترونیک شما:

CAPTCHA


XML   English Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Motamed-Jahromi S, Niami-Jahromi S. Effect of hydro-alcoholic extract of pumpkin seeds on estrogen hormone and liver markers in adult female rats. Feyz 2019; 23 (5) :455-466
URL: http://feyz.kaums.ac.ir/article-1-3706-fa.html

معتمد جهرمی سمانه، نیامی جهرمی صادق. اثر عصاره ی هیدروالکلی تخم کدوتنبل بر میزان هورمون استروژن و مارکرهای کبدی موش های صحرایی ماده ی بالغ. مجله علوم پزشکی فيض. 1398; 23 (5) :455-466

URL: http://feyz.kaums.ac.ir/article-1-3706-fa.html



Creative Commons License
This open access journal is licensed under a Creative Commons Attribution-NonCommercial ۴.۰ International License. CC BY-NC ۴. Design and publishing by Kashan University of Medical Sciences.
Copyright ۲۰۲۳© Feyz Medical Sciences Journal. All rights reserved.
دوره 23، شماره 5 - ( دوماه نامه 1398 ) برگشت به فهرست نسخه ها
مجله علوم پزشکی فیض Feyz Medical Sciences Journal
Persian site map - English site map - Created in 0.05 seconds with 46 queries by YEKTAWEB 4645