[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Journal Information::
Indexing Sources::
Guide for Authors::
Online Submission::
Articles archive::
For Reviewers::
Contact us::
Biochemistry and Nutrition in Metabolic Diseases
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
:: Volume 22, Issue 5 (Bimonthly 2018) ::
Feyz 2018, 22(5): 511-516 Back to browse issues page
Comparing the effects of 8 weeks and 12 weeks of corticosteroid therapy on serum 25-hydroxyvitamin D levels in children with nephrotic syndrome in the recovery phase
Hossein Emad-Momtaz , Amin Alsadat Sharif
Department of Pediatrics, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, I. R. Iran. , amin.sharif63@yahoo.com
Abstract:   (2939 Views)
Background: Nephrotic syndrome is a relatively common problem in childhood that can be caused by various diseases. These patients are susceptible to osteoporosis due to the nature of the disease and the complication of steroid therapy. Therefore, the aim of this study was to compare serum 25-hydroxyvitamin D levels in children with nephrotic syndrome in the recovery phase and under the two different treatment regimens.
Materials and Methods: This clinical trial study was performed on 68 children with primary nephrotic syndrome referred to the Nephrology Clinic of Besat Hospital in Hamedan in 2014. Thirty-four patients were treated for 8 weeks and 34 patients were treated for 12 weeks. The two groups were matched for age and sex. At the end of the treatment, serum 25-hydroxyvitamin D levels were measured and compared in the two groups and the rate of relapse was also assessed.
Results: There was no significant difference between the two groups in age and sex. The mean of vitamin D levels in the 8-week treatment group was significantly higher than the other group (21.61±11.39 and 16.18±9.79, respectively), and this difference was statistically significant (P=0.039). Absence of relapse was 47.1% in the 8-week treatment group and 73.5% in the 12-week treatment group, this difference was also statistically significant (P= 0.026).
Conclusion: The recurrence rate was significantly lower in the 12-week treatment compared to the 8-week treatment. However, vitamin D levels significantly decreased in this treatment group compared to the other group.
Keywords: Children, Nephrotic syndrome, Steroids, 25-Hydroxyvitamin D
Full-Text [PDF 223 kb]   (4195 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2017/08/8 | Revised: 2018/12/9 | Accepted: 2018/08/21 | Published: 2018/11/28
1. Chang JW, Tsai HL, Yang LY, Chen TJ. Epidemiology and predictors of end-stage renal disease in Taiwanese children with idiopathic nephrotic syndrome. J Epidemiol 2012; 22(6): 517-22.
2. Hinkes BG, Mucha B, Vlangos CN, Gbadegesin R, Liu J, Hasselbacher K, et al. Nephrotic syndrome in the first year of life: two thirds of cases are caused by mutations in 4 genes (NPHS1, NPHS2, WT1, and LAMB2). Pediatrics 2007; 119(4): e907-e19.
3. Rüth E-M, Kemper MJ, Leumann EP, Laube GF, Neuhaus TJ. Children with steroid-sensitive nephrotic syndrome come of age: long-term outcome. J Pediatr 2005; 147(2): 202-7.
4. Ahmadzadeh A, Valavi E, Kamali M, Ahmadzadeh A. Chronic kidney disease in Southwestern Iranian children. Iran J Pediatr 2009; 19(2): 147-53.
5. Banerjee S, Basu S, Sen A, Sengupta J. The effect of vitamin D and calcium supplementation in pediatric steroid-sensitive nephrotic syndrome. Pediatr Nephrol 2017: 1-8.
6. White RH, Glasgow EF, Mills RJ. Clinicopathologicalstudy of nephrotic syndrome in childhood. Lancet 1970; 1(7661): 1353-9.
7. Ingulli E, Tejani A. Racial differences in the incidence and renal outcome of idiopathic focal segmental glomerulosclerosis in children. Pediatr Nephrol 1991; 5(4): 393-7.
8. Kliegman R, Stanton BM, Geme JS, Schor NF. Nelson tratado de pediatría: Elsevier Brasil; 2014.
9. Buckley R, Kliegman R, Stanton B, Geme JS, Schor N, Behrman R. Nelson textbook of pediatrics. 20 ed: Phialdelphia, PA: Elsevier; 2016. 3888 p
10. Gulati S, Godbole M, Singh U, Gulati K, Srivastava A. Are children with idiopathic nephroticyndrome at risk for metabolic bone disease? Am J Kidney Dis 2003; 41(6): 1163-9.
11. Baek HS, Park KS, Kang HG, Ko CW, Cho MH. Initial steroid regimen in idiopathic nephrotic syndrome can be shortened based on duration to first remission. Korean J Pediatr 2015; 58(6): 206-10.
12. Koşan C, Ayar G, Orbak Z. Effects of steroid treatment on bone mineral metabolism in children with Glucocorticoid-sensitive Nephrotic Syndrome. West Indian Med J 2012; 61(6): 627-30.
13. Wojnar J, Roszkowska-Blaim M, Pańczyk-Tomaszewska M. Dynamics of bone biochemical markers in nephrotic children treated with prednisone and metabolites of vitamin D. Przeglad Lekarski 2007; 64(9): 552-8.
14. Polito C, La Manna A, Todisco N, Cimmaruta E, Sessa G, Pirozzi M. Bone mineral content in nephrotic children on long-term, alternate-day prednisone therapy. Clin Pediatr (Phila) 1995; 34(5): 234-6.
Send email to the article author

Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Emad-Momtaz H, Sharif A A. Comparing the effects of 8 weeks and 12 weeks of corticosteroid therapy on serum 25-hydroxyvitamin D levels in children with nephrotic syndrome in the recovery phase. Feyz 2018; 22 (5) :511-516
URL: http://feyz.kaums.ac.ir/article-1-3406-en.html

Creative Commons License
This open access journal is licensed under a Creative Commons Attribution-NonCommercial ۴.۰ International License. CC BY-NC ۴. Design and publishing by Kashan University of Medical Sciences.
Copyright ۲۰۲۳© Feyz Medical Sciences Journal. All rights reserved.
Volume 22, Issue 5 (Bimonthly 2018) Back to browse issues page
مجله علوم پزشکی فیض Feyz Medical Sciences Journal
Persian site map - English site map - Created in 0.05 seconds with 46 queries by YEKTAWEB 4652