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Comparison of corticosteroid therapy for 8 weeks with 12 weeks of treatment on serum 25-hydroxyvitamin D levels in children with nephrotic syndrome in the recovery phase
Hossein Emad Momtaz * , Amin alsadat Sharif
Hamadan University of Medical Sciences , hemmtz@yahoo.com
Abstract:   (9 Views)
Abstract:
Background: Nephrotic syndrome is a relatively common problem in childhood and is a syndrome that can be caused by various diseases. The prognosis depends on the cause of the disease and the patient's response to treatment and follow-up. Patients with nephrotic syndrome are susceptible to osteoporosis due to the nature of the disease and the complication of steroid therapy. Therefore, the purpose of this study was to compare serum 25-hydroxyvitamin D level in children with nephrotic syndrome in recovery phase and two different treatment regimens.
Materials and Methods: This clinical trial study was performed in 2014 on 68 children with Primary Nephrotic Syndrome referred to Nephrology Clinic of Besat Hospital in Hamedan. 34 patients were treated for 8 weeks and 34 patients were treated for 12 weeks. The two groups were matched for age and sex. At the end of treatment, serum 25-hydroxyvitamin D level were measured and compared in two groups and the rate of relapse was also assessed.
Results: There was no significant difference between the two groups in age and sex.The mean of vitamin D levels in the 8-week treatment group was significantly higher than the other group (21.16 and 16.16, respectively), and this difference was statistically significant (pvalue =0.039). Absence of relapse was 47.1 percent in 8-week treatment group and 73.5 percent in 12-week treatment group, this difference was also statistically significant (pvalue = 0.026).
Conclusion: The results showed that the recurrence rate was significantly lower in the 12-week treatment compared to the 8-week treatment. However, vitamin D levels also significantly decreased in this treatment group compared to the other group.
Keywords: Childs, Nephrotic Syndrome, Steroids, 25 Hydroxyvitamin D
 
Keywords: Childs, Nephrotic Syndrome, Steroids, 25 Hydroxyvitamin
     
Type of Study: Research | Subject: medicine, paraclinic
Received: 2017/08/8 | Accepted: 2018/08/21
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