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Investigation of Acetaminophen Poisoning and Factors Associated with Liver Injury in Patients Referred to Shahid Beheshti Hospital, Kashan - 2020 to 2023
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Seyyed Ali NazemRazavi    , Fatemeh Sadat Asgarian * , Hamed Pahlavani , Seyed Mojtaba Maali |
| Social Determinants of Health (SDH) Research Center, kashan University of Medical Sciences, kashan, Iran & Social Determinants of Health (SDH) Research Center, kashan University of Medical Sciences, kashan, Iran , fatisadat@yahoo.com |
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Abstract: (4 Views) |
Background and Aim:
Acetaminophen is the most common analgesic and antipyretic drug used worldwide. This study is a cross-sectional analytical study. In this study, patients hospitalized with acetaminophen poisoning in Shahid Beheshti Hospital, Kashan from 2020 to 2023 were examined.
Methods: In our study, acetaminophen poisoning was diagnosed based on the patient's history and explanations provided by the patient and the patient himself. The information required for the study included demographic characteristics (age and sex), clinical symptoms, and final status (recovery/death) of the patients. Information was extracted from the patients' files and documents and recorded in the data collection form. After describing the descriptive results and the frequency of liver damage to investigate the factors associated with liver damage, first univariate logistic regression was performed for each independent variable. Then, variables with statistical significance or clinical significance were entered into the multivariate logistic regression model using the Enter method.
Results: were reported as Odds Ratio and 95% confidence interval. Model fit was assessed using the Hosmer-Lemeshow test. Results: 101 patients were studied. Of these, 36 (35.6%) were male and 65 (64.4%) were female. The most common clinical symptoms of the patients were nausea and vomiting (67.3%). 69.3% had no liver damage and 30.7% had liver damage. Most of the patients in our study recovered and were discharged, and only 1% of the patients died.In multivariate logistic regression analysis, the frequency of acetaminophen use (OR=4.85; 95% CI: 1.92-12.25; P=0.001), time between drug use and hospitalization (OR=1.52; 95% CI: 1.02-2.27; P=0.039), and male gender (OR=14.63; CI: 1.75-122.52; P=0.013) were independently associated with liver injury.
Conclusion: Efforts to limit over-the-counter medications and to limit the prescribing of opioid-acetaminophen combinations (or separating opioids from acetaminophen) may be necessary to reduce this increasing but preventable cause. Educational programs for physicians, pharmacists, and consumers, including a thorough discussion of the risks of this common analgesic and identification of susceptible groups, appear essential.
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| Keywords: Acetaminophen overdose, Hepatotoxicity, Drug-induced liver injury |
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Type of Study: Research |
Subject:
medicine, paraclinic
Received: 2026/06/9 | Revised: 2026/09/28 | Accepted: 2026/09/28
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