:: Volume 22, Issue 5 (Bimonthly 2018) ::
Feyz 2018, 22(5): 478-486 Back to browse issues page
The effect of circuit resistance training with different intensities on the agouti-related protein, insulin and glucose plasma levels in young men
Najmeh Rezaeinezhad , Abbas Ghanbari-Niaki , Rostam Alizadeh
Department of Sports Science, Mazandaran University, Babolsar, I. R. Iran. , najmeh_rn@yahoo.com
Abstract:   (3150 Views)
Background: Agouti-related protein (AgRP) is a signaling peptide that affects feeding behavior, energy homeostasis, and the stimulation of the hypothalamic–pituitary–adrenal axis. The aim of the present study was to investigate the effect of a 6-week circuit-resistance training course (10 exercises at 20%, 40%, 60%, and 80% of 1RM) at different intensities on the levels of plasma AgRP, plasma insulin, and glucose.
Materials and Methods: The participants in this experimental study included 45 dormitory male students, aged 20-24 years, with the mean weight of 70.61±3.76 kg, mean age of 21.55±0.17 years, and mean height of 174.84±1.15 cm. They were randomly divided into five groups, each with nine members (i.e., one control group and four experimental groups at 20%, 40%, 60%, and 80% of 1RM). The experimental groups performed the circuit-resistance training exercises at the specified intensities; in contrast, the control group performed no regular training during the course of the study. The blood samples were collected from the venous vein 48 hours before and after the training session (three hours after normal breakfast).
Results: The results showed no significant differences between the groups in terms of the AgRP (P=0.399) and glucose levels (P=0.270); however, the difference related to the insulin levels was observed to be significant (P=0.013).
Conclusion: According to the results of this study, a larger reduction in the AgRP levels is associated with high intensities of resistance training (i.e., at 80% of 1RM). Therefore, training intensity could be regarded as an influential factor in reducing the appetite and controlling obesity among young men.
Keywords: Circuit-resistance training, Agouti-related protein, Normal breakfast, Training intensity
Full-Text [PDF 308 kb]   (2416 Downloads)    
Type of Study: Research | Subject: General
Received: 2018/04/8 | Revised: 2018/12/5 | Accepted: 2018/09/4 | Published: 2018/11/28
1. Horowitz JF. Fatty acid mobilization from adipose tissue during exercise. Trends Endocrinol Metabol 2003; 14(8): 386-92.
2. Do K, Laing BT, Landry T, Bunner W, Mersaud N, Matsubara T, et al. The effects of exercise on hypothalamic neurodegeneration of Alzheimer’s disease mouse model. PloS One 2018; 13(1): e0190205.
3. Rahmani GM, Rahmaninia F, Mirzaei B, Hedayati M. Effects of 8 weeks of aerobic training on agouti-related peptide, appetite hormones and insulin resistance in overweight sedentary women. Pars J Med Sci 2016; 14(2): 1-8. [in Persian]
4. Rodrigues KC, Pereira RM, de Campos TD, Moura RFd, da Silva AS, Cintra DE, et al. The Role of Physical Exercise to Improve the Browning of White Adipose Tissue via POMC Neurons. Front Cell Neurosci 2018; 12: 88.
5. Laing B, Do K, Matsubara T, Wert D, Avery M, Langdon E, et al. Voluntary exercise improves hypothalamic and metabolic function in obese mice. J Endocrinol 2016; 229(2): 109-22.
6. Loos RJ, Rankinen T, Rice T, Rao D, Leon AS, Skinner JS, et al. Two ethnic-specific polymorphisms in the human Agouti-related protein gene are associated with macronutrient intake. Am J Clin Nutrition 2005; 82(5): 1097-101.
7. Lu XY, Shieh KR, Kabbaj M, Barsh GS, Akil H, Watson SJ. Diurnal rhythm of agouti-related protein and its relation to corticosterone and food intake. Endocrinology 2002; 143(10): 3905-15.
8. Arens J, Moar KM, Eiden S, Weide K, Schmidt I, Mercer JG, et al. Age-dependent hypothalamic expression of neuropeptides in wild-type and melanocortin-4 receptor-deficient mice. Physiol Genomics 2003; 16(1): 38-46.
9. Li JY, Finniss S, Yang Y-K, Zeng Q, Qu S-Y, Barsh G, et al. Agouti-related protein-like immunoreactivity: characterization of release from hypothalamic tissue and presence in serum. Endocrinology 2000; 141(6): 1942-50.
10. Shen CP, Wu KK, Shearman LP, Camacho R, Tota MR, Fong TM, et al. Plasma Agouti‐Related Protein Level: A Possible Correlation with Fasted and Fed States in Humans and Rats. J Neuroendocrinol 2002; 14(8): 607-10.
11. Katsuki A, Sumida Y, Furuta M, Araki-sasaki R, Hori Y, Yano Y, et al. Plasma Levels of Agouti-related Protein (AGRP) Are Increased in Obese Men. J Clin Endocrinol Metabol 2001; 86(5):1921-4.
12. Ghanbari-Niaki A, Nabatchian S, Hedayati M. Plasma agouti-related protein (AGRP), growth hormone, insulin responses to a single circuit-resistance exercise in male college students. Peptides 2007; 28(5): 1035-9.
13. Zhao S, Snow RJ, Stathis C, Febbraio M, Carey M. Muscle adenine nucleotide metabolism during and in recovery from maximal exercise in humans. J Appl Physiol 2000; 88(5): 1513-9.
14. Hellsten Y, Richter EA, Kiens B, Bangsbo J. AMP deamination and purine exchange in human skeletal muscle during and after intense exercise. J Physiol 1999; 520(3): 909-20.
15. Ghanbari Niaki A, Sharifi Rigi A. Serum agouti--related protein (AGRP) response to a single session of circuit-cesistance exercise at different intensities in male college students. J Appl Exercise Physiol 2009; 5(9): 55-63. [in Persian ]
16. Hosseini-Khakhak S, Ghanbari Niaki A, Rahbarizadeh F, Mohagheghi M, Mehdi Khabazian B, Fathi R, et al. The effect of treadmill running on plasma and muscle agouti-related protein (AGRP) concentration in male rats. Iran J Endocrinol Metabol 2009; 11(4): 455-61. [in Persian]
17. Cooke WH, Carter JR. Strength training does not affect vagal–cardiac control or cardiovagal baroreflex sensitivity in young healthy subjects. Eur J Appl Physiol 2005; 93(5-6): 719-25.
18. Ghanbari Niaki A, Ardeshiri S, AliakbariBaydokhty M, Saeidi A. Effects of Circuit Resistance Training with Crocus sativus Supplementation on Insulin and Estradiol Hormones Response. Horizon Med Sci 2016; 22(2): 125-30. [in Persian]
19. Katsuki A, Sumida Y, Gabazza EC, Murashima S, Tanaka T, Furuta M, et al. Plasma levels of agouti-related protein are increased in obese men. J Clin Endocrinol Metabol 2001; 86(5): 1921-4.
20. De Rijke C, Hillebrand JJ, Verhagen L, Roeling T, Adan R. Hypothalamic neuropeptide expression following chronic food restriction in sedentary and wheel-running rats. J Molecular Endocrinol 2005; 35(2): 381-90.
21. Breen TL, Conwell IM, Wardlaw SL. Effects of fasting, leptin, and insulin on AGRP and POMC peptide release in the hypothalamus. Brain Res 2005; 1032(1-2): 141-8.
22. Rashidlamir A, Ghanbari-niaki A. Effect of 8-week circuit training on lymphocyte AGRP gene expression in well-trained wrestlers. Daneshvar 2010; 18(89): 67-72. [in Persian]
23. Ghanbari Niaki A, Rashidlamir A, Hojjati M, Ghasemi M. Effect of Feeding Glucose on AGRP, Insulin and Glucose Levels after a Session Circular Resistance Activities in Young Free Wrestlers. J App Exercise Physiol 2012; 13(4): 15-26. [in Persian ]
24. Archer ZA, Rayner DV, Mercer JG. Hypothalamic gene expression is altered in underweight but obese juvenile male Sprague-Dawley rats fed a high-energy diet. J Nutr 2004; 134(6): 1369-74.
25. Makimura H, Mizuno TM, Isoda F, Beasley J, Silverstein JH, Mobbs CV. Role of glucocorticoids in mediating effects of fasting and diabetes on hypothalamic gene expression. BMC Physiol 2003; 3(1): 5.
26. Williams G, Cai XJ, Elliott JC, Harrold JA. Anabolic neuropeptides. Physiol Behav 2004; 81(2): 211-22.
27. Wortley KE, Anderson KD, Yasenchak J, Murphy A, Valenzuela D, Diano S, et al. Agouti-related protein-deficient mice display an age-related lean phenotype. Cell Metabol 2005; 2(6): 421-7.
28. Payedar Ardakani M, Saki B, Kordi M, Gaieni A. Effect of Endurance Training on Plasma AGRP and NPY Levels in Wistar Rats. Sci J Ilam Univ Med Sci 2017; 24(6): 23-32. [in Persian]
29. Woods SC, Benoit SC, Clegg DJ, Seeley RJ. Regulation of energy homeostasis by peripheral signals. Best Pract Res Clin Endocrinol Metab 2004; 18(4): 497-515.
30. Angelopoulos N, Goula A, Tolis G. Current knowledge in the neurophysiologic modulation of obesity. Metabolism 2005; 54(9): 1202-17.
31. Sergeyev V, Broberger C, Gorbatyuk O, Hökfelt T. Effect of 2-mercaptoacetate and 2-deoxy-D-glucose administration on the expression of NPY, AGRP, POMC, MCH and hypocretin/orexin in the rat hypothalamus. Neuroreport 2000; 11(1): 117-20.
32. Lee K, Li B, Xi X, Suh Y, Martin RJ. Role of neuronal energy status in the regulation of adenosine 5′-monophosphate-activated protein kinase, orexigenic neuropeptides expression, and feeding behavior. Endocrinology 2005; 146(1): 3-10.

XML   Persian Abstract   Print

Creative Commons License
This open access journal is licensed under a Creative Commons Attribution-NonCommercial ۴.۰ International License. CC BY-NC ۴. Design and publishing by Kashan University of Medical Sciences.
Copyright ۲۰۲۳© Feyz Medical Sciences Journal. All rights reserved.
Volume 22, Issue 5 (Bimonthly 2018) Back to browse issues page