Background: Alzheimer is a Progressive dementia disease along with destruction of brain neurons and severe deficiency of memory. The present work was designed to assess the effect of the maze training in improvement of learning behavior of the Alzheimeric rats.

Materials and Methods: This experimental study was carried out on 20 Wistar male rats randomly divided in 2 groups. One group that receiving a dose of beta-amyloid intraventriculrly characterized as alzheimeric rats (ALZ). In the control group (CO) the animals were injected saline at the same volume. To assess spatial learning of the animals in the first phase of the experiment they were introduced to the Morris water maze to locate on fixed hidden platform during 4 trials/day for 5 days. Probe test was applied to evaluate the memory retrieval. In the second phase the same procedure was repeated after 20 days. The measured parameters were the time elapsed and distance passed in during the maze searching.

Results: Our findings indicated that in the first phase of experiment, the time elapsed and distance passed for the CO group were decreased compared to the ALZ group. In the second phase, however, significant variation was observable between the two tested groups. There was no significant difference between the performance of the CO and ALZ groups in probe trial testing.

Conclusion: It seems that the behavioral training positively influenced the maze learning in the ALZ subjects so that however both groups behaved similarly in the second phase of the experiment.