Background: Migraine is a prevalent neurological disorder in children and adolescents, often leading to hospitalization in severe cases. Limited data exist on the demographic and clinical profiles of hospitalized pediatric migraine patients in Iran. This study aimed to investigate these characteristics in a cohort admitted to a tertiary hospital. Methods: A cross-sectional, retrospective analysis was conducted on medical records of children under 18 years with confirmed migraine (per ICHD-3 criteria) admitted to Shahid Motahari Hospital, Urmia, Iran, from 2016 to 2021. Data on demographics, clinical symptoms, acute inpatient treatments, and discharge management were extracted using a structured checklist and analyzed with SPSS version 27, employing descriptive statistics and Fisher's exact test (p<0.05). Results: Of 154 identified cases, 110 were included (mean age 13.9 ± 3.04 years; 54.5% boys). Headache was universal, predominantly pulsating (57.3%) and unilateral (37.3%). Gastrointestinal symptoms were common (nausea/vomiting 70.9%; abdominal pain 23.6%), alongside photophobia (43.6%) and sleep disturbances (42.7%). Abdominal pain was significantly more frequent in children aged 5–10 years (p<0.001). Acute treatments included intravenous acetaminophen (96.4%) and ondansetron (92.3%). At discharge, oral ibuprofen (87.3%) and lifestyle modifications (100%) were prescribed, with prophylactics (e.g., propranolol 32.7%) in over half. Conclusions: Hospitalized pediatric migraine in this Iranian cohort featured adolescent predominance, prominent gastrointestinal and sensory symptoms, and guideline-aligned management. Age-related phenotypic variations highlight the need for tailored approaches. Larger prospective studies are warranted to refine diagnostic and therapeutic strategies in resource-limited settings.