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Effectiveness of Cognitive Rehabilitation Intervention on Memory, Processing Speed, and Executive Function in Women with Breast Cancer
Seyyedeh Mahsa Mousavi , Nader Hajlou * , Akbar Atadokht , Sajjad Basharpour , Yousef Roosta
University of Mohaghegh Ardabili, Faculty of Educational Sciences and Psychology, Ardabil, Iran , hajloo53@uma.ac.ir
Abstract:   (416 Views)
Background and Aim: Cognitive impairment is one of the important consequences of breast cancer and its treatments. This study aimed to investigate the effectiveness of a cognitive rehabilitation intervention (CRT) on memory, processing speed, and executive function in women with breast cancer.
Methods: This experimental study employed a pretest–posttest design with a three-month follow-up and was applied in nature. The statistical population included 30 women with breast cancer in Urmia City in 2024, selected through purposive sampling and randomly assigned to two groups of 15 participants each (cognitive rehabilitation and control). The cognitive rehabilitation program (CRT; 12 weekly 45-minute sessions based on Solberg & Mateer, 2001) was conducted in group format, while the control group remained on a waiting list. Posttest and three-month follow-up assessments were administered to evaluate intervention effects. The instruments included the N-Back Test (working memory), Stroop Test (selective attention and cognitive processing speed), and Wisconsin Card Sorting Test (WCST) (executive function).
Results: The results showed that the CRT intervention significantly improved memory, processing speed, and executive function, such that an increase in correct responses and a decrease in response time and reaction time were observed (p<0.01). The effect size was high for all variables (η²= 0.60-0.68). Conclusion: The findings show that cognitive rehabilitation, as a non-invasive and group-based intervention, can be effectively used in support programs for women with breast cancer and help improve cognitive function and reduce the cognitive consequences of the disease and treatment.
Keywords: Cognitive rehabilitation, memory, processing speed, executive function, breast cancer
     
Type of Study: Research | Subject: General
Received: 2025/10/8 | Revised: 2026/06/16 | Accepted: 2026/02/9
References
1. Chen YX, Zhou Y, Zhang XL, He WY, Ye Q, Xu M. Digital health interventions for cancer-related cognitive impairment in breast cancer patients: A scoping review. Digit Health. 2025; 11: 20552076251358297. doi:10.1177/20552076251358297 PMid:40677519 PMCid:PMC12268144
2. Zhang D, Xiong X, Ding H, He X, Li H, Yao Y, et al. Effectiveness of exercise-based interventions in preventing cancer therapy-related cardiac dysfunction in patients with breast cancer: A systematic review and network meta-analysis. Int J Nurs Stud. 2025;10:104997. doi:10.1016/j.ijnurstu.2025.104997 PMid:39961652
3. Farahabadi M, Amanollahi A, Cheraghian B, Abbaspoor Z. Investigation the therapeutic effect of mindfulness-based cognitive-behavioral counseling in pregnant women with body image dissatisfaction: A randomized controlled trial. Eur J Obstet Gynecol Reprod Biol X. 2025;26:100387. doi:10.1016/j.eurox.2025.100387 PMid:40276095 PMCid:PMC12020864
4. Sakki SE, Penttinen HM, Hilgert OM, Volanen SM, Saarto T, Raevuori A. Mindfulness is associated with improved psychological well-being but no change in stress biomarkers in breast cancer survivors with depression: a single group clinical pilot study. BMC Womens Health. 2022;22(1):518. doi:10.1186/s12905-022-02116-y PMid:36510201 PMCid:PMC9743600
5. Oliva G, Giustiniani A, Danesin L, Burgio F, Arcara G, Conte P. Cognitive impairment following breast cancer treatments: an umbrella review. Oncologist. 2024;29(7):e848-63. doi:10.1093/oncolo/oyae090 PMid:38723166 PMCid:PMC11224991
6. Ho MH, So TW, Fan CL, Chung YT, Lin CC. Prevalence and assessment tools of cancer-related cognitive impairment in lung cancer survivors: a systematic review and proportional meta-analysis. Support Care Cancer. 2024;32(4):209. doi:10.1007/s00520-024-08402-9 PMid:38441715 PMCid:PMC10914843
7. Park JH, Jung SJ, Lee LJ, Rhu J, Bae SH. Impact of nonpharmacological interventions on cognitive impairment in women with breast cancer: a systematic review and meta-analysis. Asia-Pac J Oncol Nurs. 2023;10(4):100212. doi:10.1016/j.apjon.2023.100212 PMid:37095894 PMCid:PMC10121786
8. Ng T, Teo SM, Yeo HL, Shwe M, Gan YX, Cheung YT, et al. Brain-derived neurotrophic factor genetic polymorphism (rs6265) is protective against chemotherapy-associated cognitive impairment in patients with early-stage breast cancer. Neuro-Oncology. 2015;18(2):244-51. doi:10.1093/neuonc/nov162 PMid:26289590 PMCid:PMC4724179
9. Rey D, Bouhnik AD, Mancini J, Bendiane MK, Séror V, Viens P. Self‐reported cognitive impairment after breast cancer treatment in young women from the ELIPPSE40 cohort: the long‐term impact of chemotherapy. Breast J. 2012;18(5):406-14. doi:10.1111/j.1524-4741.2012.01275.x PMid:22827555
10. Bonnechère B. Evaluation of processing speed of different cognitive functions across the life span using cognitive mobile games. Games Health J. 2022;11(2):132-40. doi:10.1089/g4h.2021.0144 PMid:35180366
11. Cho MG, Bender CM. Processing Speed in Patients with Cancer: A Concept Analysis. Semin Oncol Nurs. 2025;151946. doi:10.1016/j.soncn.2025.151946 PMid:40664541
12. Thornton CP, Ruble K, Jacobson LA. Beyond risk-based stratification: impacts of processing speed and executive function on adaptive skills in adolescent and young adult cancer survivors. J Adolesc Young Adult Oncol. 2021;10(3):288-95.doi:10.1089/jayao.2020.0059 PMid:32668177
13. Syarif H, Waluyo A, Afiyanti Y, Mansyur M. Executive function in breast cancer survivors and the influencing factors. Enferm Clin. 2019;29:280-5. doi:10.1016/j.enfcli.2019.04.034
14. Bail J, Meneses K, Demark-Wahnefried W. Nutritional status and diet in cancer prevention. Semin Oncol Nurs. 2016;32(3):206-214. doi:10.1016/j.soncn.2016.05.004 PMid:27539277
15. Hegel MT, Lyons KD, Hull JG, Kaufman P, Urquhart L, Li Z, et al. Feasibility study of a randomized controlled trial of a telephone‐delivered problem‐solving-occupational therapy intervention to reduce participation restrictions in rural breast cancer survivors undergoing chemotherapy. Psychooncology. 2011;20(10):1092-101. doi:10.1002/pon.1830 PMid:20821373 PMCid:PMC3005985
16. Yang P, Hu Q, Zhang L, Shen A, Zhang Z, Wang Q, et al. Effects of non-pharmacological interventions on cancer-related cognitive impairment in patients with breast cancer: A systematic review and network meta-analysis. Eur J Oncol Nurs. 2025;28:102804. doi:10.1016/j.ejon.2025.102804 PMid:39919600
17. Merceur M, Reilly KT, Bonan I, Holé J, Hummel E, Cogné M, et al. A systematic review of rehabilitation programs for cognitive impairment related to breast cancer: Different programs at different times? Ann Phys Rehabil Med. 2024; 67(5):101832. doi:10.1016/j.rehab.2024.101832 PMid:38537525
18. Wolfe DM, Hamel C, Berard J, Veroniki AA, Skidmore B, Kanji S, et al. Comparative Effectiveness of Interventions to Treat Cancer Treatment-Related Cognitive Impairment in Adult Cancer Survivors Following Systemic Therapy: A Systematic Review with Network Meta-Analyses. Cancers. 2025;17(21):3430. doi:10.3390/cancers17213430 PMid:41228226 PMCid:PMC12609492
19. Hung CS, Cheng YT, Li RH, Hillman CH, Gothe NP, Chen FT, et al. Effect of exercise interventions on cognitive function in breast cancer patients and survivors: a systematic review with meta-analysis. Breast Cancer. 2025;32(6):1180-96. doi:10.1007/s12282-025-01757-9 PMid:40826199 PMCid:PMC12552352
20. Ibrar M, Rai HK, Main A, McCartney H, Parra MA, Maguire R. Experiences of Cancer-Related Cognitive Impairment Across Cancer Types: Qualitative Systematic Review. JMIR Cancer. 2025;11:e71996. doi:10.2196/71996 PMid:41172302 PMCid:PMC12619018
21. Smith TM, Ratcliff K, Perry RA. Experiences with a cognitive rehabilitation program for five female breast cancer survivors: a focus group study. Ann Int Occup Ther. 2019;2(4):152-9. doi:10.3928/24761222-20190625-03
22. Ferguson RJ, McDonald BC, Saykin AJ, Ahles TA. Brain structure and function differences in monozygotic twins: possible effects of breast cancer chemotherapy. J Clin Oncol. 2007;25(25):3866-70.doi:10.1200/JCO.2007.10.8639 PMid:17761972 PMCid:PMC3329758
23. Meneses K, Benz R, Bail JR, Vo JB, Triebel K, Fazeli P, et al. Speed of processing training in middle-aged and older breast cancer survivors (SOAR): results of a randomized controlled pilot. Breast Cancer Res Treat. 2018;168(1):259-67. doi:10.1007/s10549-017-4564-2 PMid:29128897
24. Kleinknecht KR, Bierend M, Keim LM, Bartels F, Lampit A, Finke C. Computerized cognitive training improves cognitive function in primary breast cancer survivors. NPJ Breast Cancer. 2024;10(1):85. doi:10.1038/s41523-024-00694-8 PMid:39349493 PMCid:PMC11443049
25. Yan X, Wei S, Liu Q. Effect of cognitive training on patients with breast cancer reporting cognitive changes: a systematic review and meta-analysis. BMJ Open. 2023;13(1):e058088. doi:10.1136/bmjopen-2021-058088 PMid:36592995 PMCid:PMC9809226
26. Demos-Davies K, Lawrence J, Seelig D. Cancer related cognitive impairment: a downside of cancer treatment. Front Oncol. 2024;14:1387251. doi:10.3389/fonc.2024.1387251 PMid:38715789 PMCid:PMC11074410
27. Celorrio San Miguel AM, Cacharro LM, Santamaría G, Garrosa M, Celorrio San Miguel M, Roche E, et al. Adjuvant melatonin therapy during exercise prescription in breast cancer survivors on physical and anthropometric parameters, quality of life, and hormonal response. A randomized controlled trial. Front Sports Act Living. 2025;7:1594733. doi:10.3389/fspor.2025.1594733 PMid:40625889 PMCid:PMC12229996
28. Álvarez-Salvago F, Medina-Luque J, Pujol-Fuentes C, Atienzar-Aroca S, Molina-García C, Gutiérrez-García P, et al. Relationship of different levels of physical activity on the health status of long-term breast cancer survivors: a cross-sectional study. Disabil Rehabil. 2025:1-12. doi:10.3390/life15020177 PMid:40003586 PMCid:PMC11856788
29. Kane MJ, Conway AR, Miura TK, Colflesh GJ. Working memory, attention control, and the N-back task: a question of construct validity. J Exp Psychol Learn Mem Cogn. 2007;33(3):615. doi:10.1037/0278-7393.33.3.615 PMid:17470009
30. Amani O, Malekzadeh Moghani M, Peykani S. Evaluation of executive functions in women with breast cancer undergoing chemotherapy. Qazvin Univ Med Sci J. 2016;20(6):36-44.
31. Zare H, Moradi K, Ghazi S, Safari N, Lotfi R. Comparison of selective attention among patients with depression, obsession, anxiety, and normal individuals. Yafteh J. 2014;16(3):62-69.
32. Ajilchi B, Ahadi H, Nejati V, Dalaver A. Executive functions in depressed and non-depressed individuals. Clin Psychol. 2013;5(2):77-88.
33. Bashi Abdol Abadi H, Pilevar S, Saremi A. The effect of cognitive rehabilitation on cognitive functions, memory, depression, and anxiety in patients with multiple sclerosis. Shefa Khatam Neurosci J. 2016;4(3):28-40. doi:10.18869/acadpub.shefa.4.3.28
34. Gal-Yam EN, Harel S, Kizony R, Ben-Yakov M, Shaham B, Barkai G. Abstract P1-06-02: Remote functional cognitive rehabilitation in Breast Cancer Patients, a single center retrospective study. Clin Cancer Res. 2025;31(12):P1-06. doi:10.1158/1557-3265.SABCS24-P1-06-02
35. Alwi SM, Narayanan V, Din NC, Taib NA. Cognitive rehabilitation programs for survivors of breast cancer treated with chemotherapy: a systematic review. Rehabil Oncol. 2021;39(4):155-67.doi:10.1097/01.REO.0000000000000268
36. Sohlberg MM, Mateer CA. Cognitive rehabilitation: An integrative neuropsychological approach. Guilford Publications. 2017.
37. Tao L, Lin H, Yan Y, Xu X, Wang L, Zhang J, et al. Impairment of the executive function in breast cancer patients receiving chemotherapy treatment: a functional MRI study. Eur J Cancer Care. 2017; 26(6): e12553. doi:10.1111/ecc.12553 PMid:27436790
38. Mihuta ME, Green HJ, Shum DH. Web‐based cognitive rehabilitation for survivors of adult cancer: A randomised controlled trial. Psychooncology. 2018; 27(4):1172-79. doi:10.1002/pon.4615 PMid:29266524
39. Bray VJ, Dhillon HM, Bell ML, Kabourakis M, Fiero MH, Yip D, et al. Evaluation of a web-based cognitive rehabilitation program in cancer survivors reporting cognitive symptoms after chemotherapy. J Clin Oncol. 2017;35(2):217-25. doi:10.1200/JCO.2016.67.8201 PMid:28056205
40. Dos Santos M, Hardy-Léger I, Rigal O, Licaj I, Dauchy S, Levy C, et al. Cognitive rehabilitation program to improve cognition of cancer patients treated with chemotherapy: A 3‐arm randomized trial. Cancer. 2020;126(24):5328-36. doi:10.1002/cncr.33186 PMid:32996583 PMCid:PMC7756299
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