History and Objectives: Considering the gastric diseases and its side effects and the role of Helicobacter pylori on the disease and since discrepant reports on the role of the microorganism on the diseases and in order to determine the presence of Helicobacter pylori, the present study was carried out on gastric biopsies sent to Department of Pathology of Kashan Medical University at 1996-1997.

Materials and Methods: A descriptive study was carried on 200 gastric biopsies. In order to determine the abnormality, tissue preparation and side was stained with hematoxyllin-eosin. Pathological abnormalities were grouped into 3 groups gastritis, ulcer and neoplasia. Presence of Helicobacter pylori was confirmed by Giemsa staining. The prevalence of Helicobacter pylori and confidence level in population were determined.

Results: The prevalence of gastritis, ulcer and neoplasm were 62.5%, 19.5% and 18% respectively. 76.5% of patients showed signs of Helicobacter pylori infection. Patients with gastritis and neoplasm showed respectively the highest (78.4%) and lowest (69.5%) rate Helicobacter pylori infection.

Conclusion: Due to high rate of Helicobacter pylori infection among gastric patients, it is suggested that gastric biopsies ought to be examined for Helicobacter pylori infection the effect of drug therapy should be determined.