The Effect of a 12-Week Pilates Training Program on Serum Furin Levels and Body Mass Index in Women with Type 2 Diabetes

Montazeri Najafabadi, Zahra; Keshavarz, Saeed; Eftekhari, Elham; Mahnaz, Marvi

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Volume 29, Issue 4 (Bimonthly 2025)

Feyz Med Sci J 2025, 29(4): 341-351

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The Effect of a 12-Week Pilates Training Program on Serum Furin Levels and Body Mass Index in Women with Type 2 Diabetes

Zahra Montazeri Najafabadi

, Saeed Keshavarz ^*

, Elham Eftekhari

, Marvi Mahnaz

, keshavarz1357@gmail.com

Abstract: (149 Views)

Background and Aim: Type 2 diabetes, a common metabolic disorder, is rapidly increasing in prevalence, particularly in developing countries. Lifestyle modifications, including regular physical activity, play a pivotal role in disease management. This study aimed to investigate the effect of a 12-week Pilates training program on serum furin levels (a marker associated with endoplasmic reticulum stress and inflammation) as well as body composition indices in women with type 2 diabetes.
Methods: In this quasi-experimental study, 30 women with type 2 diabetes (aged 35–55 years) who were not engaged in regular physical activity were recruited from the Najafabad Diabetes Association. Participants were randomly assigned to either the exercise group (n = 15) or the control group (n = 15). The exercise group followed a progressive Pilates protocol for 12 weeks, three sessions per week, 50 minutes per session, while the control group continued their usual daily activities. Blood samples were collected before and after the intervention to assess serum furin levels using ELISA, and body composition indices (weight and BMI) were measured. Data were analyzed using paired t-tests in SPSS.
Results: After 12 weeks, the exercise group showed significant reductions compared with the control group in weight (mean decrease: 2.13 kg, p = 0.04), BMI (mean decrease: 1.19 kg/m², P = 0.049), fasting blood glucose (mean decrease: 12.3 mmol/L, P = 0.04), and serum furin (mean decrease: 6.6 mg/L, P = 0.001). No significant changes were observed in the control group (P ≥ 0.05).
Conclusion: These findings suggest that Pilates training may reduce serum furin levels and improve body composition, supporting its role as a complementary non-pharmacological intervention alongside conventional treatments for the management of type 2 diabetes in women.

Keywords: Pilates, Furin, Body Mass Index, Type 2 diabete

Type of Study: Research | Subject: General
Received: 2025/05/25 | Revised: 2025/09/29 | Accepted: 2025/09/9 | Published: 2025/09/29

References

1. Tomic D, Shaw JE, Magliano DJ. The burden and risks of emerging complications of diabetes mellitus. Nat Rev Endocrinol. 2022;18(9):525-39. doi.10.1038/s41574-022-00690-7 PMid:35668219 PMCid:PMC9169030

2. Matalqah SM, Al-Tawalbeh DM. Medicinal plants potential against diabetes mellitus. Diabetes. 2025; 9(10):11.

3. Wichaiyo S, Koonyosying P, Morales NP. Functional roles of furin in cardio-cerebrovascular diseases. ACS Pharmacol Transl Sci. 2024; 7(3): 570-85. doi.10.1021/acsptsci.3c00325 PMid:38481703 PMCid:PMC10928904

4. Marafie SK, Al-Mulla F. An overview of the role of furin in type 2 diabetes. Cells. 2023; 12(19):2407. doi.10.3390/cells12192407 PMid:37830621 PMCid:PMC10571965

5. Colberg SR, Sigal RJ, Yardley JE, Riddell MC, Dunstan DW, Dempsey PC, et al. Physical activity/exercise and diabetes: a position statement of the American Diabetes Association. Diabetes Care. 2016; 39(11):2065. doi.10.2337/dc16-1728 PMid:27926890 PMCid:PMC6908414

6. Tanphukwan M, Nontakhod K, Khongnam B, Wongsurin S, Buathong J, Pakkaro P, et al. Effects of pilates training on the flexibility and strength of female students. Retos. 2025; 68: 1196-205. doi.10.47197/retos.v68.115956

7. Gudymenko A, Bergdahl A, Roberts M. Effects of pilates on lower-limb strength and gait patterns in women with knee hypermobility: A preliminary study. Isokinet Exerc Sci. 2025: 09593020251327899. doi.10.1177/09593020251327899

8. Amiri S, Tofighi A, Shirpoor A, Tolouei Azar J. The Effect of 12 Weeks of High Fat Diet and Moderate Intensity Training on the KLF-15 / KLF-3 / Furin / CTRP-12 Pathway of Visceral Adipose Tissue in Male Rats. Sport Physiol Manag Investig. 2021; 13(1): 21-39.

9. Espandar N, Tofighi A, Tolouei Azar J, Khadem Ansari MH. The effect of 8 weeks of resistance, endurance, and concurrent training on serum CTRP-12, Furin, KLF-15, lipid profiles and insulin resistance in sedentary obese men. Sport Physiol. 2021; 13(49):107-36.

10. Liu Z, Chen X, Jin B, Wei W, Zhang Y, Wang X, et al. Anti-inflammatory MXene-and tannic acid-based synthetic-natural hybrid hydrogel for diabetic wound treatment by electrostimulation. Chem Eng J. 2025; 503: 158615. doi.10.1016/j.cej.2024.158615

11. Muhamad RS, Hidayat SN, Ranindya GA, Latanya RF, Hutami CM. Effects of Pilates in Reducing Depression, Anxiety, and Stress in Pregnant Women: A Systematic Review and Meta Analysis. J Soc Res. 2025; 4(8):2019-30.

12. Akhtegan S, Atashak S, Roshdi Bonab R. The changes of some total antioxidant capacity and lipid peroxidation markers following the combined with high intensity interval training in sedentary postmenopausal women. Iran J Obstet Gynecol Infertil. 2022; 24(13):70-9.

13. Güzel S, Kurcan K. The Effect of Pilates Training on Body Composition. Int J Health Exerc Sport Sci. 2024; 1(1):25-32.

14. Varra F-N, Varras M, Varra V-K, Theodosis-Nobelos P. Molecular and pathophysiological relationship between obesity and chronic inflammation in the manifestation of metabolic dysfunctions and their inflammation‑mediating treatment options. Mol Med Rep. 2024; 29(6):95. doi.10.3892/mmr.2024.13219 PMid:38606791 PMCid:PMC11025031

15. Elgedawy GA, Elabd NS, Salem RH, Awad SM, Amer AA, Torayah MM, et al. FURIN, IFNL4, and TLR2 gene polymorphisms in relation to COVID-19 severity: A case-control study in Egyptian patients. Infection. 2024;52(6):2213-29. doi.10.1007/s15010-024-02266-1 PMid:38703289 PMCid:PMC11621141

16. Kamat K, Kage V, Sequeira S. Calisthenics versus Pilates training on glycemic control and body fat in overweight individuals with type 2 diabetes mellitus. Physiother Pract Res. 2023; 44(2):99-108. doi.10.3233/PPR-220688

17. 17. Taran S, Ghorbanian B, Tutunchi H. The effect of eight weeks of Pilates exercise on serum levels of fibroblast growth factor 21 (FGF21), insulin resistance index and lipid profile in women with non-alcoholic fatty liver disease. J Appl Health Stud Sport Physiol. 2024.

18. Shiri H, Fallah H, Abolhassani M, Fooladi S, Ramezani Karim Z, Danesh B, et al. Relationship between types and levels of free fatty acids, peripheral insulin resistance, and oxidative stress in T2DM: a case-control study. PLoS One. 2024; 19(8):e0306977. doi.10.1371/journal.pone.0306977 PMid:39133724 PMCid:PMC11318896

19. Swärd P, Rosengren BE, Jehpsson L, Karlsson MK. Association between circulating furin levels, obesity and pro‐inflammatory markers in children. Acta Paediatr. 2021;110(6):1863-8. doi.10.1111/apa.15774 PMid:33486829

20. Saeidi A, Motamedi P, Hoteit M, Sadek Z, Ramadan W, Dara MM, et al. Impact of spinach thylakoid extract-induced 12-week high-intensity functional training on specific adipokines in obese males. J Int Soc Sports Nutr. 2024;21(1):2398467. doi.10.1080/15502783.2024.2398467 PMid:39308032 PMCid:PMC11421126

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Montazeri Najafabadi Z, Keshavarz S, Eftekhari E, Mahnaz M. The Effect of a 12-Week Pilates Training Program on Serum Furin Levels and Body Mass Index in Women with Type 2 Diabetes. Feyz Med Sci J 2025; 29 (4) :341-351
URL: http://feyz.kaums.ac.ir/article-1-5345-en.html

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