The Effect of a 12-Week Pilates Training Program on Serum Furin Levels and Body Mass Index in Women with Type 2 Diabetes

Montazeri Najafabadi, Zahra; Keshavarz, Saeed; Eftekhari, Elham; Mahnaz, Marvi

doi:10.48307/FMSJ.2025.29.4.341

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Volume 29, Issue 4 (Bimonthly 2025)

Feyz Med Sci J 2025, 29(4): 341-351

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The Effect of a 12-Week Pilates Training Program on Serum Furin Levels and Body Mass Index in Women with Type 2 Diabetes

Zahra Montazeri Najafabadi

, Saeed Keshavarz ^*

, Elham Eftekhari

, Marvi Mahnaz

Department of Sport Sciences, Na.C., Islamic Azad University, Najafabad, Iran , keshavarz1357@gmail.com

Abstract: (293 Views)

Background and Aim: Type 2 diabetes, a common metabolic disorder, is rapidly increasing in prevalence, particularly in developing countries. Lifestyle modifications, including regular physical activity, play a pivotal role in disease management. This study aimed to investigate the effect of a 12-week Pilates training program on serum furin levels (a marker associated with endoplasmic reticulum stress and inflammation) as well as body composition indices in women with type 2 diabetes.
Methods: In this quasi-experimental study, 30 women with type 2 diabetes (aged 35–55 years) who were not engaged in regular physical activity were recruited from the Najafabad Diabetes Association. Participants were randomly assigned to either the exercise group (n = 15) or the control group (n = 15). The exercise group followed a progressive Pilates protocol for 12 weeks, three sessions per week, 50 minutes per session, while the control group continued their usual daily activities. Blood samples were collected before and after the intervention to assess serum furin levels using ELISA, and body composition indices (weight and BMI) were measured. Data were analyzed using paired t-tests in SPSS.
Results: After 12 weeks, the exercise group showed significant reductions compared with the control group in weight (mean decrease: 2.13 kg, p = 0.04), BMI (mean decrease: 1.19 kg/m², P = 0.049), fasting blood glucose (mean decrease: 12.3 mmol/L, P = 0.04), and serum furin (mean decrease: 6.6 mg/L, P = 0.001). No significant changes were observed in the control group (P ≥ 0.05).
Conclusion: These findings suggest that Pilates training may reduce serum furin levels and improve body composition, supporting its role as a complementary non-pharmacological intervention alongside conventional treatments for the management of type 2 diabetes in women.

Keywords: Pilates, Furin, Body Mass Index, Type 2 diabete

Full-Text [PDF 476 kb] (104 Downloads)

Type of Study: Research | Subject: General
Received: 2025/05/25 | Revised: 2025/10/6 | Accepted: 2025/09/9 | Published: 2025/09/29

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‎ 10.48307/FMSJ.2025.29.4.341

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Montazeri Najafabadi Z, Keshavarz S, Eftekhari E, Mahnaz M. The Effect of a 12-Week Pilates Training Program on Serum Furin Levels and Body Mass Index in Women with Type 2 Diabetes. Feyz Med Sci J 2025; 29 (4) :341-351
URL: http://feyz.kaums.ac.ir/article-1-5345-en.html

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