[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Indexing Sources::
Guide for Authors::
Online Submission::
Ethics::
Articles archive::
For Reviewers::
Contact us::
::
Basic and Clinical Biochemistry and Nutrition
..
DOAJ
..
CINAHL
..
EBSCO
..
IMEMR
..
ISC
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
enamad
..
:: Volume 28, Issue 4 (Bimothly 2024) ::
Feyz Med Sci J 2024, 28(4): 447-455 Back to browse issues page
Curcumin and non-alcoholic fatty liver disease
Nasrin Sharifi , Somaye Kamarei , Hamed Mirzaei *
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran , h.mirzaei2002@gmail.com
Abstract:   (315 Views)
Non-Alcoholic Fatty Liver Disease (NAFLD) is the most prevalent liver disorder, characterized by the excessive accumulation of fat in the liver due to causes other than heavy alcohol consumption. The exact etiology of NAFLD remains unclear. Currently, lifestyle modifications, including diet and exercise, are the primary strategies for the prevention and treatment of NAFLD. However, certain plant bioactive compounds may also offer potential benefits for NAFLD management with acceptable safety profiles. These herbal medicines appear to play a significant role in mitigating oxidative stress by reducing insulin resistance, decreasing fat accumulation in the liver, and interacting with hepatic fat metabolism.
Turmeric (Curcuma longa), a perennial plant from the ginger family (Zingiberaceae), contains the active ingredient curcumin. With its polyphenol structure, curcumin has long been recognized as a home remedy for various ailments. Numerous studies indicate that curcumin possesses antimicrobial, anti-inflammatory, antioxidant, immune-regulating, nephroprotective, anti-cancer, hepatoprotective, and blood sugar-lowering properties through various signaling pathways and gene expression regulation.
While substantial evidence from laboratory and animal studies supports the hepatoprotective effects of curcumin, the sole human study conducted in this area yielded inconclusive results. Therefore, this study aims to present a selection of definitive findings regarding the effects of curcumin/turmeric on NAFLD.
Keywords: Curcumin, Turmeric, Non-Alcoholic Fatty Liver Disease
Full-Text [PDF 798 kb]   (133 Downloads)    
Type of Study: Review | Subject: medicine, paraclinic
Received: 2024/06/2 | Revised: 2024/11/5 | Accepted: 2024/09/18 | Published: 2024/10/23
References
1. Mokhtari Z, Gibson DL, Hekmatdoost A. Nonalcoholic Fatty Liver Disease, the Gut Microbiome, and Diet. Adv Nutr. 2017;8(2):240-52. doi:10.3945/an.116.013151
2. Younossi ZM. Non-alcoholic fatty liver disease - A global public health perspective. J Hepatol. 2019; 70(3): 531-44. doi:10.1016/j.jhep.2018.10.033
3. Eslamparast T, Poustchi H, Zamani F, Sharafkhah M, Malekzadeh R, Hekmatdoost A. Synbiotic supplementation in nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled pilot study. Am J Clin Nutr. 2014; 99(3): 535-42. doi:10.3945/ajcn.113.068890
4. Foschi FG, Bedogni G, Domenicali M, Giacomoni P, Dall'Aglio AC, Dazzani F, et al. Prevalence of and risk factors for fatty liver in the general population of Northern Italy: the Bagnacavallo Study. BMC Gastroenterol. 2018; 18(1): 177. doi:10.1186/s12876-018-0906-8
5. Sharifi N, Amani R, Hajiani E, Cheraghian B. Women may respond different from men to vitamin D supplementation regarding cardiometabolic biomarkers. Exp Biol Med (Maywood). 2016;241 (8):830-8. doi:10.1177/1535370216629009
6. Byrne CD, Targher G. NAFLD: a multisystem disease. J Hepatol. 2015;62(1 Suppl):S47-64. doi:10.1016/j.jhep.2014.12.012
7. Buzzetti E, Pinzani M, Tsochatzis EA. The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD). Metabolism. 2016; 65(8): 1038-48. doi:10.1016/j.metabol.2015.12.012
8. Darand M, Alavian SM, Hekmatdoost A. Nigella sativa and Non-Alcoholic Fatty Liver Disease: A Review of the Current Evidence. Hepat Mon. 2018; 18(10): e68046. doi:10.5812/hepatmon.68046
9. Ghaemi A, Taleban FA, Hekmatdoost A, Rafiei A, Hosseini V, Amiri Z, et al. How Much Weight Loss is Effective on Nonalcoholic Fatty Liver Disease? Hepat Mon. 2013; 13(12): e15227. doi:10.5812/hepatmon.15227
10. Noori M, Jafari B, Hekmatdoost A. Pomegranate juice prevents development of non-alcoholic fatty liver disease in rats by attenuating oxidative stress and inflammation. J Sci Food Agric. 2017; 97(8): 2327-32. doi:10.1002/jsfa.8042
11. Rahimlou M, Ahmadnia H, Hekmatdoost A. Dietary supplements and pediatric non-alcoholic fatty liver disease: Present and the future. World J Hepatol. 2015; 7(25): 2597-602. doi:10.4254/wjh.v7.i25.2597
12. Rahimlou M, Yari Z, Hekmatdoost A, Alavian SM, Keshavarz SA. Ginger Supplementation in Nonalcoholic Fatty Liver Disease: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. Hepat Mon. 2016; 16(1): e34897. doi:10.5812/hepatmon.34897
13. Talari HR, Molaqanbari MR, Mokfi M, Taghizadeh M, Bahmani F, Tabatabaei SMH, et al. The effects of vitamin B12 supplementation on metabolic profile of patients with non-alcoholic fatty liver disease: a randomized controlled trial. Sci Rep. 2022;12(1):14047. doi:10.1038/s41598-022-18195-8
14. Sharifi N, Amani R. Vitamin D supplementation and non-alcoholic fatty liver disease: A critical and systematic review of clinical trials. Crit Rev Food Sci Nutr. 2019;59(4):693-703. doi:10.1080/10408398.2017.1389693
15. Sharifi N, Amani R, Hajiani E, Cheraghian B. Does vitamin D improve liver enzymes, oxidative stress, and inflammatory biomarkers in adults with non-alcoholic fatty liver disease? A randomized clinical trial. Endocrine. 2014; 47(1): 70-80.doi:10.1007/s12020-014-0336-5
16. Mohtashamian A, Ebrahimzadeh A, Shamekhi Z, Sharifi N. Nigella sativa supplementation and non-alcoholic fatty liver disease: A systematic review of clinical trials. Avicenna J Phytomed. 2023;13(1):18-33.
17. Fuloria S, Mehta J, Chandel A, Sekar M, Rani N, Begum MY, et al. A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin. Front Pharmacol. 2022;13:820806.doi:10.3389/fphar.2022.820806
18. Panahi Y, Alishiri GH, Parvin S, Sahebkar A. Mitigation of Systemic Oxidative Stress by Curcuminoids in Osteoarthritis: Results of a Randomized Controlled Trial. J Diet Suppl. 2016;13 (2): 209-20. doi:10.3109/19390211.2015.1008611
19. Alm-Eldeen AA, Mona MH, Shati AA, El-Mekkawy HI. Synergistic effect of black tea and curcumin in improving the hepatotoxicity induced by aflatoxin B1 in rats. Toxicol Ind Health. 2015;31 (12):1269-80. doi:10.1177/0748233713491807
20. Dattani JJ, Rajput DK, Moid N, Highland HN, George LB, Desai KR. Ameliorative effect of curcumin on hepatotoxicity induced by chloroquine phosphate. Environ Toxicol Pharmacol. 2010;30(2): 103-9. doi:10.1016/j.etap.2010.04.001
21. Coban D, Milenkovic D, Chanet A, Khallou-Laschet J, Sabbe L, Palagani A, et al. Dietary curcumin inhibits atherosclerosis by affecting the expression of genes involved in leukocyte adhesion and transendothelial migration. Mol Nutr Food Res. 2012;56(8):1270-81. doi:10.1002/mnfr.201100818
22. Leclercq IA, Farrell GC, Sempoux C, dela Pena A, Horsmans Y. Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice. J Hepatol. 2004;41(6):926-34. doi:10.1016/j.jhep.2004.08.010
23. Rahmani S, Asgary S, Askari G, Keshvari M, Hatamipour M, Feizi A, et al. Treatment of Non-alcoholic Fatty Liver Disease with Curcumin: A Randomized Placebo-controlled Trial. Phytother Res. 2016;30(9):1540-8. doi:10.1002/ptr.5659
24. Kocher A, Bohnert L, Schiborr C, Frank J. Highly bioavailable micellar curcuminoids accumulate in blood, are safe and do not reduce blood lipids and inflammation markers in moderately hyperlipidemic individuals. Mol Nutr Food Res. 2016; 60(7): 1555-63. doi:10.1002/mnfr.201501034
25. Ganjali S, Sahebkar A, Mahdipour E, Jamialahmadi K, Torabi S, Akhlaghi S, et al. Investigation of the effects of curcumin on serum cytokines in obese individuals: a randomized controlled trial. ScientificWorldJournal. 2014; 2014: 898361. doi:10.1155/2014/898361
26. Demir M, Lang S, Steffen HM. Nonalcoholic fatty liver disease - current status and future directions. J Dig Dis. 2015;16(10):541-57. doi:10.1111/1751-2980.12291
27. Tiniakos DG, Vos MB, Brunt EM. Nonalcoholic fatty liver disease: pathology and pathogenesis. Annu Rev Pathol. 2010;5:145-71. doi:10.1146/annurev-pathol-121808-102132
28. Abu-Shanab A, Quigley EM. The role of the gut microbiota in nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol. 2010;7(12):691-701. doi:10.1038/nrgastro.2010.172
29. 29. Angulo P. Long-term mortality in nonalcoholic fatty liver disease: is liver histology of any prognostic significance? Hepatology. 2010; 51(2): 373-5. doi:10.1002/hep.23521
30. Soderberg C, Stal P, Askling J, Glaumann H, Lindberg G, Marmur J, et al. Decreased survival of subjects with elevated liver function tests during a 28-year follow-up. Hepatology. 2010; 51(2): 595-602. doi:10.1002/hep.23314
31. Zhou Y, Llaurado G, Oresic M, Hyotylainen T, Orho-Melander M, Yki-Jarvinen H. Circulating triacylglycerol signatures and insulin sensitivity in NAFLD associated with the E167K variant in TM6SF2. J Hepatol. 2015;62(3):657-63. doi:10.1016/j.jhep.2014.10.010
32. Lomonaco R, Ortiz-Lopez C, Orsak B, Webb A, Hardies J, Darland C, et al. Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease. Hepatology. 2012;55(5):1389-97. doi:10.1002/hep.25539
33. Sanyal AJ, Campbell-Sargent C, Mirshahi F, Rizzo WB, Contos MJ, Sterling RK, et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology. 2001; 120(5): 1183-92. doi:10.1053/gast.2001.23256
34. Pagano G, Pacini G, Musso G, Gambino R, Mecca F, Depetris N, et al. Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: further evidence for an etiologic association. Hepatology. 2002;35(2):367-72. doi:10.1053/jhep.2002.30690
35. Dumas ME, Kinross J, Nicholson JK. Metabolic phenotyping and systems biology approaches to understanding metabolic syndrome and fatty liver disease. Gastroenterology. 2014;146(1):46-62. doi:10.1053/j.gastro.2013.11.001
36. Schuppan D, Schattenberg JM. Non-alcoholic steatohepatitis: pathogenesis and novel therapeutic approaches. J Gastroenterol Hepatol. 2013; 28 Suppl 1:68-76. doi:10.1111/jgh.12212
37. Day CP, James OF. Steatohepatitis: a tale of two "hits"? Gastroenterology. 1998; 114(4): 842-5.doi:10.1016/S0016-5085(98)70599-2
38. Berson A, De Beco V, Letteron P, Robin MA, Moreau C, El Kahwaji J, et al. Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes. Gastroenterology. 1998;114(4):764-74. doi:10.1016/S0016-5085(98)70590-6
39. Tilg H, Moschen AR. Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. Hepatology. 2010;52(5): 1836-46. doi:10.1002/hep.24001
40. Urošević M, Nikolić L, Gajić I, Nikolić V, Dinić A, Miljković V. Curcumin: Biological Activities and Modern Pharmaceutical Forms. Antibiotics (Basel). 2022;11(2). doi:10.3390/antibiotics11020135
41. Gupta SC, Patchva S, Koh W, Aggarwal BB. Discovery of curcumin, a component of golden spice, and its miraculous biological activities. Clin Exp Pharmacol Physiol. 2012;39(3):283-99. doi:10.1111/j.1440-1681.2011.05648.x
42. Siviero A, Gallo E, Maggini V, Gori L, Mugelli A, Firenzuoli F, et al. Curcumin, a golden spice with a low bioavailability. J Herbal Med. 2015; 5(2): 57-70. doi:10.1016/j.hermed.2015.03.001
43. Bernabe-Pineda M, Ramirez-Silva MT, Romero-Romo M, Gonzalez-Vergara E, Rojas-Hernandez A. Determination of acidity constants of curcumin in aqueous solution and apparent rate constant of its decomposition. Spectrochim Acta A Mol Biomol Spectrosc. 2004;60(5):1091-7. doi:10.1016/S1386-1425(03)00342-1
44. Jayaprakasha GK, Jaganmohan Rao L, Sakariah KK. Antioxidant activities of curcumin, demethoxycurcumin and bisdemethoxycurcumin. Food Chem. 2006; 98(4): 720-4. doi:10.1016/j.foodchem.2005.06.037
45. Galano A, Álvarez-Diduk R, Ramírez-Silva MT, Alarcón-Ángeles G, Rojas-Hernández A. Role of the reacting free radicals on the antioxidant mechanism of curcumin. Chem Physics. 2009; 363(1): 13-23. doi:10.1016/j.chemphys.2009.07.003
46. Panahi Y, Kianpour P, Mohtashami R, Jafari R, Simental-Mendia LE, Sahebkar A. Efficacy and Safety of Phytosomal Curcumin in Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Trial. Drug Res (Stuttg). 2017;67(4):244-51. doi:10.1055/s-0043-100019
47. Navekar R, Rafraf M, Ghaffari A, Asghari-Jafarabadi M, Khoshbaten M. Turmeric Supplementation Improves Serum Glucose Indices and Leptin Levels in Patients with Nonalcoholic Fatty Liver Diseases. J Am Coll Nutr. 2017; 36(4): 261-7. doi:10.1080/07315724.2016.1267597
48. Chirapongsathorn S, Jearjesdakul J, Sanpajit T, Juthaputthi A, editors. Curcumin trend to improve alanine transaminase (ALT) in non-alcoholic fatty liver disease (NAFLD) with abnormal ALT. Journal of Gastroenterology and Hepatology; 2012: WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-5774, NJ USA.
49. Wei Z, Liu N, Tantai X, Xing X, Xiao C, Chen L, et al. The effects of curcumin on the metabolic parameters of non-alcoholic fatty liver disease: a meta-analysis of randomized controlled trials. Hepatol Int. 2019; 13(3): 302-13. doi:10.1007/s12072-018-9910-x
50. Panahi Y, Kianpour P, Mohtashami R, Soflaei SS, Sahebkar A. Efficacy of phospholipidated curcumin in nonalcoholic fatty liver disease: a clinical study. J Asian Nat Prod Res. 2019; 21(8): 798-805. doi:10.1080/10286020.2018.1505873
51. Benedict M, Zhang X. Non-alcoholic fatty liver disease: An expanded review. World J Hepatol. 2017; 9(16): 715-32. doi:10.4254/wjh.v9.i16.715
52. Lobo R, Prabhu KS, Shirwaikar A, Shirwaikar A. Curcuma zedoaria Rosc. (white turmeric): a review of its chemical, pharmacological and ethnomedicinal properties. J Pharm Pharmacol. 2009; 61(1): 13-21. doi:10.1211/jpp/61.01.0003
53. Chalasani N, Younossi Z, Lavine JE, Charlton M, Cusi K, Rinella M, et al. The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases. Hepatology. 2018; 67(1): 328-57. doi:10.1002/hep.29367
54. Jazayeri-Tehrani SA, Rezayat SM, Mansouri S, Qorbani M, Alavian SM, Daneshi-Maskooni M, et al. Efficacy of nanocurcumin supplementation on insulin resistance, lipids, inflammatory factors and nesfatin among obese patients with non-alcoholic fatty liver disease (NAFLD): a trial protocol. BMJ Open. 2017; 7(7): e016914. doi:10.1136/bmjopen-2017-016914
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Sharifi N, Kamarei S, Mirzaei H. Curcumin and non-alcoholic fatty liver disease. Feyz Med Sci J 2024; 28 (4) :447-455
URL: http://feyz.kaums.ac.ir/article-1-5188-en.html


Creative Commons License
This open access journal is licensed under a Creative Commons Attribution-NonCommercial ۴.۰ International License. CC BY-NC ۴. Design and publishing by Kashan University of Medical Sciences.
Copyright ۲۰۲۳© Feyz Medical Sciences Journal. All rights reserved.
Volume 28, Issue 4 (Bimothly 2024) Back to browse issues page
مجله علوم پزشکی فیض Feyz Medical Sciences Journal
Persian site map - English site map - Created in 0.05 seconds with 46 queries by YEKTAWEB 4660