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:: Volume 28, Issue 5 (Bimonthly 2024) ::
Feyz Med Sci J 2024, 28(5): 463-470 Back to browse issues page
Effect of 8-week swimming exercise and zinc supplementation on renal function markers following unilateral ureteral obstruction in rats
Hossein Ansari , Elham Eftekhari * , Jamshid Banaie , Said Keshavarz
Sport Medicine Research Center, Najafabad Branch, Islamic Azad University, Najafabad, Iran , E.eftekhari66@gmail.com
Abstract:   (744 Views)
Background and Aim: Acute kidney diseases impose a significant burden on long-term hospitalizations. The aim of this study was to determine the effect of 8 weeks of swimming exercise and zinc supplementation on renal function markers following unilateral ureteral obstruction in rats.
Methods: In this experimental study, 32 nephrectomized rats aged 8-10 weeks and weighing 190-220 grams were randomly divided into 4 groups: 1) nephrectomy control (Nef), 2) swimming training (ST), 3) zinc supplementation (Z), and 4) swimming training + zinc supplementation (ST+Z). Additionally, 8 healthy rats were included as a normal control group to assess the effects of unilateral ureteral obstruction. The ST and ST+Z groups swam for 8 weeks, 3 sessions per week, for 20-45 minutes each session in a special animal pool. The Z and ST+Z groups also received 30 mg/kg zinc sulfate daily by gavage. Serum creatinine, hemoglobin, sodium, potassium, and phosphorus levels were measured.
Results: Sodium and creatinine levels were significantly lower in the Z, ST, and ST+Z groups compared to the Nef group (P≤0.05). Potassium levels were significantly lower in the Z group compared to the Nef group (P=0.018). Phosphorus levels were significantly lower in the ST+Z group compared to the Nef group (P=0.003).
Conclusion: The results of this study showed that exercise and zinc supplementation have interactive effects on improving ion balance and reducing serum creatinine following unilateral ureteral obstruction in animal models. Therefore, it is suggested that the combination of swimming exercise and zinc supplementation be used in conditions of kidney disorders.
Keywords: Exercise, Zinc supplementation, Creatinine, Hemoglobin, Nephrectomy
Full-Text [PDF 383 kb]   (479 Downloads)    
Type of Study: Research | Subject: General
Received: 2023/12/19 | Revised: 2024/12/25 | Accepted: 2024/10/16 | Published: 2024/12/23
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Ansari H, Eftekhari E, Banaie J, Keshavarz S. Effect of 8-week swimming exercise and zinc supplementation on renal function markers following unilateral ureteral obstruction in rats. Feyz Med Sci J 2024; 28 (5) :463-470
URL: http://feyz.kaums.ac.ir/article-1-5071-en.html


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Volume 28, Issue 5 (Bimonthly 2024) Back to browse issues page
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