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Investigating the effect of eight weeks of swimming training with zinc supplementation on some kidney function markers in rats following complete unilateral ureter obstruction in rats
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Hossein Ansari    , Elham Eftekhari * , Jamshid Banaie , Said Keshavarz |
| , E.eftekhari66@gmail.com |
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Abstract: (133 Views) |
Introduction: Today, acute kidney diseases are known as the biggest challenge with the highest number of deaths. Therefore, the aim this study was to investigating the effect of eight weeks of swimming training with zinc supplementation on some kidney function markers in rats following complete unilateral ureter obstruction in rats.
Methods: In this experimental study, 32 nephrectomized rats aged 8-10 weeks and weighing 190-220 grams were randomly divided into 4 groups including 1) nephrectomy control (Nef), 2) swimming training (ST), 3) zinc supplementation (Z), and 4) swimming training + zinc supplementation (ST+Z); Also, in order to investigate the effects of unilateral uretera obstruction, 8 healthy rats were selected as healthy control (HC) group. ST and ST+Z groups swam in the special animal pool for 8 weeks, three sessions a week and 20-45 minutes in each. Z and ST+Z groups received 30 mg/kg/day zinc sulfate. One-way analysis of variance along with Tukey's post-hoc tests were used for statistical analysis of data (P≤0.05).
Results: Na and creatinine in the Z, ST and ST+Z groups were significantly lower than the Nef group (P≤0.05). K levels in Z group were significantly lower than Nef group (P=0.018). Phosphorus levels in the ST+Z group were significantly lower than the Nef group (P=0.003).
Conclusion: Generally, ST and zinc supplementation have interactive effects on improving ions and reducing serum creatinine following complete unilateral uretera obstruction in animal models. Although the role of each one alone is also significant; Therefore, it is suggested to use the interaction of ST and zinc supplement in conditions of kidney disorders. |
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| Keywords: Training, Zinc, Electrolytes, Creatinine, Hemoglobin, Nephrectomy |
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Type of Study: Research |
Subject:
General
Received: 2023/12/19 | Revised: 2024/10/29 | Accepted: 2024/10/16
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