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:: Volume 27, Issue 2 (Bimonthly 2023) ::
Feyz Med Sci J 2023, 27(2): 225-235 Back to browse issues page
The effect of exercise training on the circulating levels of BDNF in patients with multiple sclerosis: a systematic review with meta-analysis
Mousa Khalafi * , Mohammad Borzuk , Amir Ghanbarpour
Department of Physical Education and Sports Sciences, Faculty of Humanities, University of Kashan, Kashan, I.R. Iran. , mousa.khalafi@kashanu.ac.ir
Abstract:   (1258 Views)
Background: Brain-derived neurogenic factor (BDNF) plays an effective role in improving neurological processes, therefore it is a therapeutic target for patients with multiple sclerosis (MS). This meta-analysis aimed to investigate the effect of exercise training on the circulating levels of BDNF in patients with MS.
Materials and Methods: PubMed, Scopus and Web of Science databases were searched until April 2023 for exercise training studies on BDNF circulation levels in MS patients. This search was performed using the keywords: "exercise training", "BDNF" and "MS". Standardized mean difference (SMD) effect sizes and 95% confidence intervals were calculated using CMA2 software.
Results: 20 exercise interventions from a total of 15 studies including 603 subjects with MS were included in the meta-analysis. The results of data analysis showed that exercise training with a small and significant effect size leads to an increase in the circulating levels of BDNF in patients with MS [0.45 (CI: 0.18 to 0.72), P=0.001].
Conclusions: exercise training leads to the positive regulation of BDNF in patients with MS, which may play an important role in controlling this disease.
Keywords: Exercise training, BDNF, Multiple sclerosis
Full-Text [PDF 458 kb]   (676 Downloads)    
Type of Study: Review | Subject: General
Received: 2023/02/12 | Revised: 2023/07/25 | Accepted: 2023/05/9 | Published: 2023/06/14
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Khalafi M, Borzuk M, Ghanbarpour A. The effect of exercise training on the circulating levels of BDNF in patients with multiple sclerosis: a systematic review with meta-analysis. Feyz Med Sci J 2023; 27 (2) :225-235
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