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:: Volume 26, Issue 5 (Bimonthly 2022) ::
Feyz Med Sci J 2022, 26(5): 521-529 Back to browse issues page
The effect of aerobic exercise with pistachio skin extract on the expression of Bax, caspase-3 and Bcl-2 in heart tissue of fat-fed rats
Mohammad Kazemipour , Hasan Mateen Homaie * , Parvin Farzanegi
Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, I.R. Iran. , hasanmatinhomaee@gmail.com
Abstract:   (1272 Views)
Background: Fatty diet increases apoptosis and cardiovascular disease. Therefore, this study aimed to evaluate the effect of 4-week aerobic exercise along with pistachio skin extract on the expression of Bax, caspase-3 and Bcl-2 in heart tissue of fat-fed rats.
Materials and Methods: This is an experimental study. 12-week-old female rats were randomly divided into 5 groups of 6; Positive control (healthy), negative control (obesity), exercise + obesity, extract + obesity, exercise and extract + obesity (interaction of exercise and extract). Training was done for 4 weeks with moderate intensity of 50-60% Vo2max. Pistachio skin extract was used at a dose of 60 mg per kilogram. qPCR method was used to check gene expression.
Results: The results showed that the expression of bax and caspase 3 was higher in the obese group than in the healthy group (P=0.001). The extract groups, the exercise group and the exercise + extract group had more bax and caspase 3 expression compared to the obese group (P=0.001). The expression of Bcl-2 in the obese group and the exercise group was lower than the healthy group (P=0.001). Also, the expression of Bcl-2 was higher in the exercise + extract group than in the obese group (P=0.001). There was a significant difference between the exercise group and the exercise+extract group with the extract group.
Conclusion: High-fat diet increase bax and caspase 3 and decreased Bcl-2 in rats. However, exercise and consumption of green pistachio skin extract together decrease bax and caspase 3 and increased Bcl-2.
Keywords: High fat diet, Aerobic exercise, Pistachio skin, Apoptosis
Full-Text [PDF 419 kb]   (522 Downloads)    
Type of Study: Research | Subject: General
Received: 2022/06/10 | Revised: 2023/01/30 | Accepted: 2022/09/13 | Published: 2022/12/4
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Kazemipour M, Mateen Homaie H, Farzanegi P. The effect of aerobic exercise with pistachio skin extract on the expression of Bax, caspase-3 and Bcl-2 in heart tissue of fat-fed rats. Feyz Med Sci J 2022; 26 (5) :521-529
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Volume 26, Issue 5 (Bimonthly 2022) Back to browse issues page
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