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The effect of 4 weeks high-intensity interval training (HIIT) on the content of PPARγ and PRDM16 proteins subcutaneous adipose tissue in obese diabetic Sprague-Dawley male rats
Maryamalsadat Hashemi Taklimi , Maryam Shabani , Saeedeh Shadmehri * , Mohammad Sherafati Moghadam , Mohammad Fathalipour
Yadegar-e-imam Khomeini (RAH) Shahr-e Ray Branch , saeedeh.sh61@gmail.com
Abstract:   (78 Views)
Background: Today, important proteins and pathways have been identified that lead to the regulation of the adipose tissue and Converting it to brown fat tissue, the proteins PPARγ and PRDM16 are key proteins in this setting. diabetes is one of the major causes of obesity and complications that can interfere in the function of these two proteins. The aim of this study was to investigate the effect of 4 weeks high-intensity interval training (HIIT) on the content of PPARγ and PRDM16 proteins subcutaneous adipose tissue in obese diabetic Sprague-Dawley male rats.
Materials and Methods: In this experimental study, 16 Sprague-Dawley male rats (with mean weight of 300 ± 20 gr) were selected and after induction of diabetes by STZ and nicotinamide was randomly assigned into two groups: diabetic training and diabetic control. The experimental group performed 4 days a week the exercise training for 4 weeks, while the control group did not have any training program. Independent T-test was used to analyze the data.
Results: There was no significant change in the content of PPARγ (P=0.16) and PRDM16 (P=0.83) proteins after 4 weeks of HIIT training in training group compared to the control group.
  • According to the results of this study, HIIT training has not significantly changed the content of PPARγ and PRDM16 proteins. It seems to the intensity of HIIT training be a major contributor to the result that should be taken into consideration.
Keywords: Diabetes, High-Intensity Interval Training, PPARγ, PRDM16, White Fat Tissue
     
Type of Study: Research | Subject: General
Received: 2019/01/15 | Accepted: 2019/06/1
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