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Effects of combined therapy with resveratrol, continuous and interval exercises on levels of apoptotic biomarkers in cardiomyocytes of male rats with non-alcoholic fatty liver
Hossein Mahdian , Parvin Farzanegi * , Amin Farzaneh-Hessari
Department of Exercise Physiology, Sari Branch, Islamic Azad University, Sari, I.R. Iran. , Parvin.farzanegi@gmail.com
Abstract:   (62 Views)
Background and objective: Non-alcoholic fatty liver (NAFLD) is one of the most common chronic liver diseases. In this study, combined therapy with resveratrol supplementation alone or in combination with exercise trainings was considered on cardiomyocytes apoptosis in heart tissue of rats with NAFLD.
 
Methods: In this experimental study, a total of 56 male Wistar rats were divided into control and seven experimental NAFLD groups including, patient, saline, resveratrol (RSV), continuous exercise, interval exercise, continuous exercise + RSV, and interval exercise + RSV. Apoptosis biomarkers, including Bax and Bcl2 levels were measured in the heart of all groups using specific ELISA kits.
 
Results: Bax level in the heart tissue of patients and saline groups (29.95 ± 5.83 and 28.37 ± 5.83 ng/mg/protein, respectively) was significantly higher than that in other groups (p<0.0001), while Bcl2 concentration was significantly decreased (p<0.0001). The mean ratio of Bax/Bcl2 in patients (23.02±7.65) and saline (20.43±5.29) was significantly higher than in other groups (p<0.001). Resveratrol supplementation alone or in combination with exercise trainings significantly decreased the cardiac Bax content, but significantly increased the cardiac Bcl2 level (p<0.001).
 
Conclusion: NAFLD is associated with increased apoptotic biomarkers in heart cells. Although resveratrol alone has an anti-apoptotic properties, combined therapy with interval and continuous trainings is more effective.
Keywords: apoptosis, non-alcoholic fatty liver, interval and continuous trainings, resveratrol
     
Type of Study: Research | Subject: General
Received: 2018/05/3 | Accepted: 2018/09/23
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