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The effect of curcumin on biochemical and hematological indices of red blood cells during and after taking ecstasy in male wistar rats
Naser Khalaji * , Fahimeh Sadeghi , Yousef Rasmi
Urmia University of Medical Sciences , khalaji.Naser@gmail.com
Abstract:   (54 Views)
Abstract:
 
 Background & aims: One of the problems of the human societies is using of ecstasy pills or 3, 4-methylenedioxymethamphetamine (MDMA) that those are used in circles and parties. Since these pills have severe damage to various system of the body, including blood cells. Therefore, in this study, we investigated the protective effect of curcumin (turmeric extract) on red blood cells and its hematological and biochemical indices with and after taking ecstasy.
Materials & Methods: In this experimental study 40 adult male wistar rats were divided into five groups: group1; control  (received ethyl oleate 0.2 ml, IP, and 2 ml water in the form of  oral for 15 days, without MDMA and Curcumin), group 2 (received MDMA 20 mg/kg in 2 ml distilted water in the form of oral and ethyl oleate 0.2 ml, IP, for 15 days), group 3 (received MDMA 20 mg/kg and injection of curcumin 20 µ mol, IP, for 15 days), group 4 (received MDMA 20 mg/kg, for 15 days, then 15 days later , no drug injection), group 5 (received MDMA 20 mg/kg, for 15 days, then injection of curcumin 20 µ mol, IP, for 15 days later. The rats were anesthetized at the end of experiment. The blood samples were collected. Some biochemical parameters, red blood cells and its indices were measured. The blood smears were prepared.
 Results: The result of this study showed that the mean of red blood cell levels were significantly lower in MDMA recipient groups than in the control group (P<0.05). and when using curcumin during and after taking ecstasy the level of red blood cells and hemoglobin were significantly decreased compared with that in the control group (P<0.05). Reducing red blood cells in curcumin recipient groups were also significant in compared with MDMA groups (P<0.05). The total bilirubin levels in 2 and 4 groups which received MDMA alone , as well as in 3 and 5 groups that received MDMA with curcumin were significantly higher than control group (P<0.05).
Conclusion: Consumption of curcumin with and after taking ecstasy increased the complication of MDMA on the red blood cells and its hematological and biochemical indices in male rats. This effect is likely due to high digestive absorption of MDMA by curcumin and or non metabolism of MDMA when using curcumin, which from this finding, the specific feature of curcumin, can be used to increase digestive absorption of some medication and foods in the future.  
 
Keywords: Addiction, Ecstasy, Red blood cells, billirubin, Curcumin
     
Type of Study: Research | Subject: medicine, paraclinic
Received: 2018/04/11 | Accepted: 2018/07/4
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