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Zinc oxide Nanoparticle reduces oxidative stress in the presence and absence of vitamin C
Maryam Rafieirad * , Saeed Valipour-Chahardah-Charic
Assistant Professor , rafieirad.m@gmail.com
Abstract:   (139 Views)
Background: In recent years, attention has been paid to the potential effects of nanoscale materials on the central nervous system. The cerebellum is one of the areas of the brain with high absorption of zinc. Therefore, the aim of this study was to evaluate the effects of zinc oxide on oxidative stress indices of cerebellar rats in presence and absence of vitamin C. Methods: In this experimental study, Wistar male rats (250-200g) were divided into 10­groups (n=7) contains:: Saline group, Three groups received doses of 1.25, 2.5 and 5 (mg/kg) of zinc­oxide Nanoparticle, Three groups received doses of 30, 60 and 120 (mg/kg) of vitamin ­C and three groups receiving zinc 1/25, 2.5 and 5 with 30 mg/kg of vitamin­ C. 30 minutes after receiving the drug, the rats were immediately beheaded and the cerebellum of their brains was removed to evaluate the stress oxidative indexes such as Malondialdehyde and total thiol content. Results: The MDA levels significantly decreased in the groups receiving 5(mg/kg) of zinc oxide NPs, and receiving  different doses of vitamin­ C, and also decreased in the groups receiving1.25, 2.5 and 5(mg/kg) zinc oxide NPs with 30  mg/kg vitamin­ C compared to the saline group. In thiol measurements, total Thiol concentration increased in the group receiving 1.25, 2.5 and 5mg/kg nano­oxide in combination with vitamin­ C in comparison with saline although not significant. Conclusion: Zinc nanoxide seems to have a reduced effect on the amount of oxidative stress in the presence and absence of vitamin­ C in a dose of 5 mg­/­kg in the animal model.
Keywords: zinc oxide NPs, Malondialdehyde, thiol, vitamin C, rats
     
Type of Study: Research | Subject: General
Received: 2018/01/31 | Accepted: 2018/05/7
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