Background: Burger's disease has various presentations. During the present study we have determined the clinical manifestations of Burger's disease in a group of patients referring to Taleghani hospital in 2000-01.

Materials and Methods: It was a descriptive study. Diagnosis was confirmed in accordance with clinical manifestations and angiography. Patients’ clinical signs and symptoms as well as other demographic data were recorded.

Results: 42 patients with definite diagnosis of Burger's disease and the mean age of 35.9±2 years were included. All were male and smoker. 71% had addiction and 54.8% had previous history of smoking for more than 10-20 years. Poor health status was reported in 69%. Clinical manifestations were: Resting pain (81%), ischemic ulcer, intermittent claudication, thrombophlebitis and upper limb’s pain.

Conclusion: Our patients’ clinical signs and symptoms have differed with reports of western societies. Poor socioeconomic and health status are the major risk factors. Further studies are highly recommended.