[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 21, Number 3 (Bimonthly 2017) ::
Feyz 2017, 21(3): 240-246 Back to browse issues page
Assessing the loading and release of metronidazole from bacterial cellulose film as a pharmaceutical dressing
Mohammad Ali Salehi, Mojtaba Akbari, Masomeh Jahani-kadosarai
Department of Chemical Engineering, Faculty of Engineering, University of Guilan, Guilan, I. R. Iran. , jahanimasomeh@yahoo.com
Abstract:   (109 Views)
Background: Bacterial cellulose membrane (BCM) produced by Gluconacetobacter xylinus is an advantageous bacterial product and because of its unique properties could be used as an ideal dressing. The aim of this study was to consider the capability of this biomaterial in the release of Metronidazole. In the case of proving this capability, it provides the basis for the production of a dressing containing this type of antibiotic.
Materials and Methods: In this study, BCM was initially synthesized by Gluconacetobacter xylinus. The BCM was loaded by Metronidazole. Then the release process was considered in distilled water and buffer phosphate Saline. The ultra violet spectrophotometry was applied for measuring the concentration of the released drug.
Results: The chemical structure of bacterial cellulose was confirmed by Fourier Transform Infrared (FT-IR) spectroscopy. The release of Metronidazole in distilled water and phosphate buffered Saline was reached to 84.27% and 84.71%, respectively. Due to higher release in phosphate buffered Saline media, it seems that the trend of release in vitro provides efficient results.
Conclusion: Results of this study provides the basis for future research on supplying an ideal dressing from this microbial product.
Keywords: Dressing, Drug release, Bacterial cellulose, Gluconacetobacter xylinus, Metronidazole
Full-Text [PDF 355 kb]   (35 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2015/11/22 | Accepted: 2017/04/26 | Published: 2017/07/30
1. Poormohammadi Mojaveri A, Sattari M, Jafari Azar Z, Ghaffari AR, Ariapanah P. Evaluation of the efficiency of bacterial cellulose synthesized by acetobacter xylinum in absorption and release of tetracycline hydrochloride. Arak Med Univ J 2011; 14(3): 20-6. [in Persian]
2. Lin WC, Lien CC, Yeh HJ, Yu CM, Hsu SH. Bacterial cellulose and bacterial cellulose–chitosan membranes for wound dressing applications. Carbohydrate Polymers 2013; 94(1): 603-11.
3. Castro C, Zuluage R, Alvarez C, Putaux JL, Caro G, Rojas O, et al. Carbohydrate Polymers 2012; 89(4): 1033-7.
4. Sheykhnazari S, Tabarsa T, Ashori A, Shakeri A, Golalipour M. Bacterial synthesized cellulose nanofibers; Effects of growth times and culture mediums on the structural characteristics. Carbohydrate Polymers 2011; 86(3): 1187–91.
5. Kamarudin S, Kalil MS, Takrif MS, Wan Yusoff WM, Biak A, Radiah D, Hasan N. Different media formulation on biocellulose production by acetobacter xylinum (0416). Pertanika J Sci Technol 2013; 21(1): 29-36.
6. Keshk SM. Vitamin C enhances bacterial cellulose production in Gluconacetobacter xylinus. Carbohydrate Polymers 2014; 99: 98-100.
7. Ul-Islam M, Hwan Ha J, Khan T, Kon Park J. Effects of glucuronic acid oligomers on the production, structure and properties of bacterial cellulose. Carbohydrate Polymers 2013; 92(1): 360–6.
8. Dayal MS, Gowswami N, Sahai A, Jain V, Mathur G, Mathur A. Effect of media components on cell growth and bacterial cellulose production from Acetobacter aceti MTCC 2623. Carbohydrate Polymers 2013; 94(1): 12–6.
9. Musa H, Sule YZ, Gwarzo MS. Assessment of physicochemical properties of metronidazole tablets marketed in Zaria, Nigeria. Int J Pharmacy Pharm Sci 2011; 3(Suppl 3): 27-9.
10. Silva NHCS, Rodrigues AF, Almeida IF, Costa PC, Rosado C, Neto CP, et al. Bacterial cellulose membranes as transdermal delivery systems for diclofenac: In vitro dissolution and permeation studies. Carbohydrate Polymers 2014; 106: 264–9.
11. Silva NH, Drumond I, Almeida IF, Costa P, Rosado, Neto CP, et al. Topical caffeine delivery using biocellulose membranes: a potential innovative system for cellulite treatment. Cellulose 2014; 21(1): 665–74.
12. Morits S, Wiegand C, Wesarg F, Hessler, Muller FA, Kralisch D, et al. Active wound dressings based on bacterial nanocellulose as drug delivery system for octenidine. Int J Pharm 2014; 471(1): 45–55.
13. Trovatti E, Freire CS, Pinto PC, Almeida IF, Costa P, Silvestre AJ, et al. Bacterial cellulose membranes applied in topical and transdermal delivery of lidocaine hydrochloride and ibuprofen: In vitro diffusion studies. Int J Pharm 2012; 435(1): 83-7.
14. Taheri R, Ajoudanifar H, Porali P. Production of cellulose from native bacterial isolates isolated in Iran. J Microbial World 2014; 6(4): 273-80.
15. Ishihara M, Matsunaga M, Hayashi N, Tis ler V. Utilization of D-xylose as carbon source for production of bacterial cellulose. Enzyme Microbial Technol 2002; 31(7): 986–91.
Send email to the article author

Add your comments about this article
Your username or email:

Write the security code in the box >

XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Salehi M A, Akbari M, Jahani-kadosarai M. Assessing the loading and release of metronidazole from bacterial cellulose film as a pharmaceutical dressing. Feyz. 2017; 21 (3) :240-246
URL: http://feyz.kaums.ac.ir/article-1-2830-en.html
Volume 21, Number 3 (Bimonthly 2017) Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
Persian site map - English site map - Created in 0.049 seconds with 803 queries by yektaweb 3461