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:: Volume 16, Issue 7 (Supplement 2013) ::
Feyz 2013, 16(7): 763-764 Back to browse issues page
Trace element disturbances in pancreatic cancer
Mohammad Amin Ahmadi-Faghih *, Leila Farzin, Fattaneh Sajjadi
Atomic Energy Organization of Iran (AEOI) , mahmadi@aeoi.org.ir
Abstract:   (4342 Views)

Background: Pancreatic cancer (PC) is still a major health problem worldwide. Little is known about the etiology of pancreatic cancer as an important cause of cancer mortality in developed countries.

Materials and Methods: In this study, we measured the serum Zn, Se, Cu and Cd levels of PC patients compared to healthy subjects from the same region in Iran, using atomic absorption spectrometry. We have also examined the contributions of age, sex and smoking status to overall risk for PC.

Results: In this case-control study, a significant difference in both Zn and Cd levels was observed between PC and control group (P<0.001 and P<0.0001, respectively). Zn level in Pc cases was 63.12±26.45 μg/dL and this value was found statistically lower compared to the controls (107.05±30.23 μg/dl). The mean concentration of Cd in patients (3.10±1.05 μg/l) was higher than the healthy subjects (1.52±0.88 μg/l). Moreover, no significant difference was observed for Se and Cu between the two groups (P>0.05). Taking into consideration the sex of the subjects, a significant decrease in serum Zn levels of PC patients was observed in females compared to males (P<0.01).

Conclusion: We found that Cd is a plausible pancreatic carcinogen. In addition, a significant relationship between Zn metabolism and PC is suggested.

Keywords: Trace elements, Pancreatic cancer, Atomic absorption spectrometry
Full-Text [PDF 122 kb]   (898 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2013/03/5
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Ahmadi-Faghih M A, Farzin L, Sajjadi F. Trace element disturbances in pancreatic cancer. Feyz. 2013; 16 (7) :763-764
URL: http://feyz.kaums.ac.ir/article-1-1852-en.html

Volume 16, Issue 7 (Supplement 2013) Back to browse issues page
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