Background: Harmful effects of heavy metals on human health have been reported in different studies. This study was carried out to assess the status of some heavy metals in atmospheric dusts of Isfahan region during two seasons of Autumn and Winter.

Materials and Methods: Sampling was done from 60 points with similar altitude using glass traps and heavy metals content was determined with the flame atomic absorption spectrometry in dusts.

Results: Results showed that concentration of Cadmium, Lead and Zinc rather than the other elements is higher than the threshold limit of the soil. Also, the presence of a significant correlation signified their common sources.

Conclusion: Differences were observed for elements in two seasons but the differences were significantly for Zinc and Nickel which may be due to the wind velocity and its direction and amount of rainfall in the region. High concentration of heavy metals in dusts and their accumulation in soil surface results in soil pollution and entrance to food chain. In addition, the breathing of the elements is harmful for humans.