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:: Volume 16, Issue 7 (Supplement 2013) ::
Feyz 2013, 16(7): 679-680 Back to browse issues page
The effect of Trientine and flaxseed oil on serum Copper and lipoproteins in diabetic rats
Esfandiar Heidarian *, Elham Pournajaf, Ali Rezaei
Shahrekord University of Medical Sciences , heidarian46@yahoo.com
Abstract:   (5184 Views)

Background: Diabetes causes disorders in serum trace elements and lipoprotein metabolism. The aim of this study was to determine the effect of co-administration of trientine (Cu chelator agent) and flaxseed oil on serum copper and lipoproteins in diabetic rats.

Materials and Methods: Rats were divided into five groups. Diabetes was induced in 4 groups. Group I received Trientine plus flaxseed oil, group II the standard diet plus Trientine, Group III flaxseed oil and group IV was a diabetic group without treatment. Group V received the standard diet as a control group. After 2 months, the serum Cu2+, TG, Chol, and HDL-C were determined.

Results: In the Trientine plus flaxseed oil group, the serum TG and LDL significantly decreased (P<0.05) compared to the other groups. Also, the serum Chol in supplemented Trientine plus flaxseed oil group decreased (P<0.05) compared to the group which received the standard diet plus Trientine. HDL-C in group received standard diet plus Trientine significantly increased (P<0.05) compared to the other groups. In the group that received Trientine, the serum Cu2+ significantly decreased (P<0.05) compared to the other groups. Moreover, the serum Cu2+ in group received Trientine plus flaxseed oil significantly decreased (P<0.05) compared to the groups that received flaxseed oil and a diabetic group without treatment. In the flaxseed oil group, the serum Cu2+ significantly elevated (P<0.05) compared to the other groups, but this group showed no salient difference (P>0.05) compared to a diabetic group without treatment.

Conclusion: The usage of Cu2+ chelator such as Trientine may reduce the side effects of Cu2+ in diabetes. Co-administration of flaxseed oil plus Trientine significantly reduced the serum of Cu2+ and biochemical parameters such as TG, TC, LDL-C, and Chol in diabetes.

Keywords: Diabetes, Serum Cu, Flaxseed oil, Serum lipids, Trientine
Full-Text [PDF 122 kb]   (806 Downloads)    
Type of Study: Research | Subject: General
Received: 2013/03/3
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Heidarian E, Pournajaf E, Rezaei A. The effect of Trientine and flaxseed oil on serum Copper and lipoproteins in diabetic rats. Feyz. 2013; 16 (7) :679-680
URL: http://feyz.kaums.ac.ir/article-1-1805-en.html


Volume 16, Issue 7 (Supplement 2013) Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
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