[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 16, Issue 7 (Supplement 2013) ::
Feyz 2013, 16(7): 597-598 Back to browse issues page
Protective effect of zinc on serum parameters related to thyroid and parathyroid glands in rats exposed to cadmium
Elham Moshtaghi *, Pedram Malekpouri, Ahmad Ghorchani
Islamic Azad University , moshtaghie.e@gmail.com
Abstract:   (4996 Views)

Background: Cadmium is one of the toxic metals, which can enter the body through several routes due to its numerous applications and lead to some disorders. This study aimed to investigate the protective effect of zinc on cadmium-induced damages in the serum parameters related to the thyroid and parathyroid glands.

Materials and Methods: In this study, 40 male rats weighting 201±30g were divided into the four separated groups (consisting of 5 rats): the cadmium treatment, zinc treatment, combination of zinc and cadmium and control groups. The normal saline containing 1 mg cadmium was injected intrapritoneally to the rats as the first treatment. The second group was treated with 0.5 mg zinc, the third one received the combined doses of cadmium (1mg) and zinc (0.5mg) and the control group received only the normal saline injection. At the end of the experiment (30 and 60 d), all rats were decapitated and sera collected to measure the serum parameters related to the thyroid and parathyroid glands.

Results: The obtained results showed that cadmium significantly (P<0.05) decreased the concentration of serum calcium, T3, T4 and calcitonin, but increased the Pi concentration and the activity of Paratormone and alkaline phosphatase. Zinc treatment in animals either maintained all the aforementioned serum parameters at their normal levels or at least showed a preventive-like role.

Conclusion: Although a long-term injection of cadmium provides hypothyroidism as well as hyperparathyroidism, zinc can be able to reduce the toxic effects of cadmium.

Keywords: Zinc, Cadmium, Thyroid, Parathyroid
Full-Text [PDF 102 kb]   (873 Downloads)    
Type of Study: Research | Subject: General
Received: 2013/02/26
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Moshtaghi E, Malekpouri P, Ghorchani A. Protective effect of zinc on serum parameters related to thyroid and parathyroid glands in rats exposed to cadmium. Feyz. 2013; 16 (7) :597-598
URL: http://feyz.kaums.ac.ir/article-1-1760-en.html


Volume 16, Issue 7 (Supplement 2013) Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
Persian site map - English site map - Created in 0.05 seconds with 32 queries by YEKTAWEB 3920