:: دوره 26، شماره 6 - ( دوماه نامه 1401 ) ::
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نقش چرخه 1- کربن در فرآیند اسپرماتوژنز و باروری: مقاله مروری
الهام قجری ، شقایق کیانی ، نوشین نادری ، مرضیه تولائی* ، محمد حسن مشکی باف ، محمد حسین نصر اصفهانی
پژوهشگاه رویان، پژوهشکده زیست‌فناوری جهاد دانشگاهی، مرکز تحقیقات پزشکی تولیدمثل، گروه زیست‌فناوری جانوری، اصفهان، ایران ، Tavalaee.royan@gmail.com
چکیده:   (271 مشاهده)
سابقه و هدف: اسپرماتوژنز فرآیندی است که به تولید و تمایز اسپرم منجر می‌شود. در طی این فرآیند، مسیرهای مولکولی و متابولیسم‌های مختلفی درگیر هستند. «چرخه 1- کربن» به‌عنوان یکی از مهم‌ترین چرخه‌های متابولیکی که شامل دو چرخه فولات و متیونین و مسیر ترانس‌سولفوراسیون می‌باشد، شناخته شده است. این چرخه در متیلاسیون DNA و RNA، تراکم و بلوغ DNA و حفظ تعادل آنتی‌اکسیدانی در اسپرم نقش‌های ضروری و حیاتی دارد. در این مطالعه مروری، به اهمیت چرخه 1- کربن در فرآیند اسپرماتوژنز پرداخته شده است.
مواد و روش‌ها: با استفاده از چندین واژگان کلیدی، مطالعات مربوط از پایگاه‌های PubMed وScholar Google  و Science Direct بین سال‌های 1993 تا 2021 به زبان انگلیسی بررسی شدند که اطلاعات 69 مقاله منتخب، استخراج گردید.
نتایج: اختلال در متابولیسم چرخه 1- کربن مانند مسیر ترانس‌سولفوراسیون، روند متیلاسیون مجدد، کمبود فولات یا کوبالامین و وجود پلی‌مورفیسم تک‌نوکلئوتیدی ژن MTHFR واریانت C677T، می‌تواند بر متیلاسیون DNA و RNA و سلامت DNA اسپرم تأثیرگذار باشد. افزایش غلظت هموسیستئین به‌ویژه در افراد با کمبود فولات، با افزایش استرس‌ اکسیداتیو و کاهش آنتی‌اکسیدان‌ها در سلول همراه است که می‌تواند بر عملکرد و توانایی باروری اسپرم مؤثر ‌باشد.
نتیجه‌گیری: ممکن است تقویت چرخه 1- کربن با فولات و دیگر ریز‌مغذی‌ها بتواند با فعال‌کردن آنزیم‌های دخیل در مسیر ترانس‌سولفوراسیون و کاهش غلظت هموسیستئین، به بهبود پارامترهای اسپرمی و پتانسیل باروری منجر شود.
واژه‌های کلیدی: باروری مردان، چرخه 1- کربن، گلوتاتیون، مسیر ترانس سولفوراسیون، اسپرم
متن کامل [PDF 457 kb]   (59 دریافت)    
نوع مطالعه: مروري | موضوع مقاله: عمومى
دریافت: 1401/7/2 | پذیرش: 1401/9/28 | انتشار: 1401/12/3
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دوره 26، شماره 6 - ( دوماه نامه 1401 ) برگشت به فهرست نسخه ها