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:: Volume 26, Issue 4 (Bimonthly 2022) ::
Feyz 2022, 26(4): 416-423 Back to browse issues page
The effect of high intensity interval training and caloric restriction on inflammatory factors and periplipin3 visceral adipose tissue in male Wistar rats with type 2 diabetes
Arash Alimoradi , Hasan Mateen-Homaie * , Saleh Rahmati
Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences٫ Central Tehran Branch٫ Islamic Azad University٫ Tehran٫ I.R. Iran. , hasanmatinhomaee@gmail.com
Abstract:   (211 Views)
Background: There is ample evidence in the study of the association of inflammatory reactions with the pathogenesis and complications of diabetes, especially hyperlipidemia and atherosclerosis. This study aimed to the effect of high intensity interval training and caloric restriction on inflammatory factors and PLIN3 visceral adipose tissue in male diabetic rats.
Materials and Methods: 32 diabetic male Wistar rats was randomly divided into three subgroups: HIIT, control and caloric restriction. In the caloric restriction group, 40% of the calorie intake was restricted and other groups received the standard food they needed freely. Relative protein expression of PLIN3 was performed using western blot technique and TNF-α and IL-6 by ELISA. Data were analyzed by one-way ANOVA and Tukey's post hoc test.
Result: There was a significant difference between the mean of PLIN3, IL-6 and TNF-α in the three groups (P=0.001). The results of post hoc test showed a significant increase in PLIN3 and a significant decrease in IL-6 and TNF-α in the caloric restriction group and intense intermittent exercise compared to the diabetic control group (P=0.001).
Conclusion: HIIT and caloric restriction may increase lipid oxidation by increasing PLIN3 expression. Considering the role of TNF-α and IL-6 in increasing insulin resistance and type 2 diabetes, reducing these factors during the present study may be helpful in preventing these metabolic diseases.
Keywords: HIIT, Caloric restriction, PLIN3, IL-6
Full-Text [PDF 379 kb]   (71 Downloads)    
Type of Study: Research | Subject: General
Received: 2022/04/26 | Accepted: 2022/08/14 | Published: 2022/09/26
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Alimoradi A, Mateen-Homaie H, Rahmati S. The effect of high intensity interval training and caloric restriction on inflammatory factors and periplipin3 visceral adipose tissue in male Wistar rats with type 2 diabetes. Feyz 2022; 26 (4) :416-423
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Volume 26, Issue 4 (Bimonthly 2022) Back to browse issues page
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