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:: Volume 25, Issue 1 (Bimonthly 2021) ::
Feyz 2021, 25(1): 732-742 Back to browse issues page
The effect of moderate intensity running training on reproductive system alteration induced by acetyl salicylic acid (Aspirin) in adult Wistar rats
Mehdi Asadi , Mohammad Rahmani * , Ali Kalantari-Hesari , Esmail Nasiri , Milad Khosravi-Sadr , Naghi Sabalani , Mahmood Tajik-Khaveh
Department of Exercise Science, Faculty of Humanities, Shahed University, Tehran, I.R. Iran. , rahmani@shahed.ac.ir
Abstract:   (518 Views)
Background: Acetyl salicylic acid (ASA) or Aspirin is one of the most widely used drugs in the world; one of its side effects is the male reproductive system alteration. The present study aimed to investigate the effect of moderate intensity aerobic exercise on ASA-induced reproductive system alteration in rats.
Materials and Methods: In two stages, fifteen rats (N=15) were randomly divided into control (C, n=5), non-treatment (NT, n=5) and aerobic-treatment (AT, n=5) groups; the AT and NT groups used aspirin 12.5 mg/kg-daily/five weeks. The AT group ran at moderate intensity on a rodent-treadmill/four weeks, five sessions a week. Groups C and NT did not receive any intervention. Serum testosterone level, spermatogenesis indices and sperm parameters of rats were evaluated and the data were analyzed by one-way variance and Tukey post-hoc-test at alpha level 0.05 by SPSS.
Results: Data statistical analysis showed that there was a significant difference between the groups in terms of serum testosterone level (P=0.02), sperm quantity (P=0.0001), viability (P=0.001), maturity (P=0.0001), sperm DNA fracture (P=0.002), TDI, SI and RI indices, tubule diameter (P=0.0001), tubular epithelium thickness (P=0.0001) and number of Leydig cells (P=0.003), but there was no significant difference between the groups in terms of sperm motility (P=0.07). Tukey post-hoc-test showed that these differences were between NT and AT groups, but no significant difference was observed between C and AT.
Conclusion: It can be concluded that four-week moderate exercise helps accelerate the reproductive conditions recovery to just before taking acetyl salicylic acid (ASA) or Aspirin.
Keywords: Aerobic exercise, Acetyl salicylic acid, Aspirin, Testosterone, Reproductive system, Rat
Full-Text [PDF 1486 kb]   (87 Downloads)    
Type of Study: Research | Subject: General
Received: 2020/10/27 | Accepted: 2021/01/29 | Published: 2021/04/6
References
1. Webb PM, Na R, Weiderpass E, Adami HO, Anderson KE, Bertrand KA, et al. Use of aspirin, other nonsteroidal anti-inflammatory drugs and acetaminophen and risk of endometrial cancer: The Epidemiology of Endometrial Cancer Consortium. Ann Oncol 2019; 30(2):310–6.
2. Patrono C. Aspirin. In: Michelson A., Cattaneo M., Frelinger A., Newman PJ., editors. Platelets. Academic Press; 2019. p. 921–36.
3. Banihani SA. Effect of aspirin on semen quality: A review. Andrologia 2020;52(1):3–8.
4. Ibtisham F, Jinjun C. Aspirin affect on reproduction of male rat an-overview. Pharm Pharmacol Int J. 2016;4(4):387-390.
5. Vane JR, Botting RM. The mechanism of action of aspirin. Thromb Res 2003; 15;110(5-6):255-8.
6. Pannunzio A, Coluccia M. Cyclooxygenase-1 (COX-1) and COX-1 inhibitors in cancer: A review of oncology and medicinal chemistry literature.Pharmaceuticals 2018; 11(4): 101.
7. Balaji T, Ramanathan M, Menon VP. Localization of cyclooxygenase-2 in mice vas deferens and its effects on fertility upon suppression using nimesulide-A preferential cyclooxygenase-2 inhibitor. Toxicology 2007;234(1–2):135–44.
8. Gupta C, Bentlejewski CA. Role of Prostaglandins in the Testosterone-Dependent Wolffian Duct Differentiation of the Fetal Mouse1. Biol Reprod 1992;47(6):1151–60.
9. Jain N, Shrivastava R, Raghuwanshi AK, Shrivastava VK. The Effect Of Aspirin On Reproductive Organs Of Female Albino Rat. IJPSR 2012;3(8):8.
10. Banihani SA, Shatnawi RM. Aspirin decreases human sperm motility and vitality, chelates seminal calcium, but insignificantly reduces seminal nitric oxide production. Andrologia 2020; 52:e13776.
11. Ibtisham F, Chen J, Niu Y, Wang Z, Wu J, Xiao M, An L. Effect of Aspirin on Reproductive Profile of Male Rat An-Overview. Int J Res Dev Pharm L Sci. 2016;5(4):5-12
12. Vyas A, Ram H, Purohit A, Jatwa R. Adverse Effects of Subchronic Dose of Aspirin on Reproductive Profile of Male Rats. J Pharm 2016;2016:1–9.
13. Hocaoglu C. The Psychosocial Aspect of Infertility. In: Dhastagir S. editor. Infertility, Assisted Reproductive Technologies and Hormone Assays IntechOpen; 2019: 201–214.
14. Kumar N, Singh A. Trends of male factor infertility, an important cause of infertility: A review of literature. J Hum Reprod Sci 2015;8(4):191.
15. Ilacqua A, Izzo G, Emerenziani G Pietro, Baldari C, Aversa A. Lifestyle and fertility: the influence of stress and quality of life on male fertility. Reprod Biol Endocrinol 2018;16(1):115.
16. Fiuza-Luces C, Garatachea N, Berger NA, Lucia A. Exercise is the Real Polypill. Physiology 2013; 28(5): 330–58.
17. Zhao X, Bian Y, Sun Y, Li L, Wang L, Zhao C, et al. Effects of moderate exercise over different phases on age-related physiological dysfunction in testes of SAMP8 mice. Exp Gerontol 2013;48(9):869–80.
18. Yi X, Gao H, Chen D, Tang D, Huang W, Li T, et al. Effects of obesity and exercise on testicular leptin signal transduction and testosterone biosynthesis in male mice. Am J Physiol - Regul Integr Comp Physiol 2017;312(4):R501–10.
19. Magalhães J, Ascensão A, Padrão AI, Aleixo IM, Santos-Alves E, Rocha-Rodrigues S, et al. Can exercise training counteract doxorubicin-induced oxidative damage of testis proteome? Toxicol Lett 2017;5;280:57–69.
20. Hajizadeh Maleki B, Tartibian B. Resistance exercise modulates male factor infertility through anti-inflammatory and antioxidative mechanisms in infertile men: A RCT . Vol. 203, Life Sciences. Elsevier Inc; 2018. 150-160 p.
21. Hajizadeh Maleki B, Tartibian B. Moderate aerobic exercise training for improving reproductive function in infertile patients: A randomized controlled trial. Cytokine 2017;92:55–67.
22. Hajizadeh Maleki B, Tartibian B, Mooren FC, Krüger K, FitzGerald LZ, Chehrazi M. A randomized controlled trial examining the effects of 16 weeks of moderate-to-intensive cycling and honey supplementation on lymphocyte oxidative DNA damage and cytokine changes in male road cyclists. Cytokine 2016; 88: 222–31.
23. Hajizadeh Maleki B, Tartibian B. High-intensity interval training modulates male factor infertility through anti-inflammatory and antioxidative mechanisms in infertile men: A randomized controlled trial. Cytokine 2020;125:154861.
24. Hajizadeh Maleki B, Tartibian B. Resistance exercise modulates male factor infertility through anti-inflammatory and antioxidative mechanisms in infertile men: A RCT. Life Sci 2018; 203: 150–60.
25. Manna I, Jana K, Samanta PK. Effect of different intensities of swimming exercise on testicular oxidative stress and reproductive dysfunction in mature male albino Wistar rats. Indian J Exp Biol 2004;42(8):816–22.
26. Jana K, Samanta PK, Manna I, Ghosh P, Singh N, Khetan RP, et al. Protective effect of sodium selenite and zinc sulfate on intensive swimming-induced testicular gamatogenic and steroidogenic disorders in mature male rats. Appl Physiol Nutr Metab 2008;33(5):903–14.
27. Asadi M, Rahmani M, Nasiri E., kalantari-hesari A, Khosravi-sadr M.,Ezzatifar M. Histomorpho-metric and histologic effect of endurance swimming on the testis of adult wistar rats. J Appl Exerc Physiol 2020; 16(31): 59–70. [in Persian]
28. Vaamonde D, Garcia-Manso JM, Hackney AC. Impact of physical activity and exercise on male reproductive potential: a new assessment questionnaire. Rev Andal Med Deporte 2017; 10 (2): 79-93.
29. Machado MV, Vieira AB, da Conceição FG, Nascimento AR, da Nóbrega ACL, Tibirica E. Exercise training dose differentially alters muscle and heart capillary density and metabolic functions in an obese rat with metabolic syndrome. Exp Physiol 2017; 102(12): 1716–28.
30. Samadian Z, Tofighi A, Razi M, Tolouei Azar J, Ghaderi Pakdel F. Moderate-intensity exercise training ameliorates the diabetes-suppressed spermatogenesis and improves sperm parameters: Insole and simultaneous with insulin. Andrologia 2019;51(11):e13457.
31. Semet M, Paci M, Saïas-Magnan J, Metzler-Guillemain C, Boissier R, Lejeune H, et al. The impact of drugs on male fertility: a review. Andrology 2017; 5(4):640-63.
32. Hall PF, Irby DC, De Kretser DM. Conversion of cholesterol to androgens by rat testes: comparison of interstitial cells and seminiferous tubules. Endocrinology 1969; 84(3):488–96.
33. Wang W, Wei S, Li L, Su X, Du C, Li F, et al. Proteomic analysis of murine testes lipid droplets. Scientific reports 2015; 10:5(1):1-9.
34. Smith LB, Walker WH. The regulation of spermatogenesis by androgens. Vol. 30, Seminars in Cell & Developmental Biology 2014; 1 (30): 2–13.
35. Zhou R, Wu J, Liu B, Jiang Y, Chen W, Li J, et al. The roles and mechanisms of Leydig cells and myoid cells in regulating spermatogenesis Cell Mol Life Sci 2019; 76(14): 2681–95.
36. Samadian Z, Tofighi A, Razi M, Tolouei Azar J, Ghaderi Pakdel F. Moderate-intensity exercise training ameliorates the diabetes-suppressed spermatogenesis and improves sperm parameters: Insole and simultaneous with insulin. Andrologia 2019;51(11).
37. Chigurupati S, Son TG, Hyun DH, Lathia JD, Mughal MR, Savell J, et al. Lifelong running reduces oxidative stress and degenerative changes in the testes of mice. J Endocrinol 2008;199(2):333–41.
38. Manna I, Jana K, Samanta PK. Effect of different intensities of swimming exercise on testicular oxidative stress and reproductive dysfunction in mature male albino Wistar rats. Indian J Exp Biol 2004; 42(8):816–22.
39. Matos B, Howl J, Ferreira R, Fardilha M. Exploring the effect of exercise training on testicular function. Eur J Appl Physiol 2018; 119(1):1-8.
40. Safarinejad MR, Azma K, Kolahi AA. The effects of intensive , long-term treadmill running on reproductive hormones , hypothalamus – pituitary – testis axis , and semen quality : a randomized controlled study. J Endocrinol 2009;200(3):259-71.
41. Scheffer DL, Silva LA, Tromm CB, da Rosa GL, Silveira PCL, de Souza CT, et al. Impact of different resistance training protocols on muscular oxidative stress parameters. Appl Physiol Nutr Metab 2012;37(6):1239–46.
42. Rex DK, Ahnen DJ, Baron JA, Batts KP, Burke CA, Burt RW, et al. Serrated Lesions of the Colorectum: Review and Recommendations From an Expert Panel. Am J Gastroenterol 2012;107(9):1315–29.
43. Gaskins AJ, Mendiola J, Afeiche M, Jørgensen N, Swan SH, Chavarro JE. Physical activity and television watching in relation to semen quality in young men. Br J Sports Med 2015; 49(4):265–70.
44. Priskorn L, Jensen TK, Bang AK, Nordkap L, Joensen UN, Lassen TH, et al. Is Sedentary Lifestyle Associated With Testicular Function? A Cross-Sectional Study of 1,210 Men. Am J Epidemiol 2016; 184(4):284–94.
45. Vaamonde D, Da Silva-Grigoletto ME, García-Manso JM, Barrera N, Vaamonde-Lemos R. Physically active men show better semen parameters and hormone values than sedentary men. Eur J Appl Physiol 2012;112(9):3267–73.
46. Hajizadeh Maleki B, Tartibian B, Chehrazi M. The effects of three different exercise modalities on markers of male reproduction in healthy subjects: A randomized controlled trial. Reproduction 2017; 153(2):157-174.
47. Fallah Mohammadi M, Hajizadeh Moghaddam A, Mirkarimpur H. The effects of a moderate exercise program on knee osteoarthritis in male wistar rats. Iran J Basic Med Sci 2013;16(5):683–8.
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Asadi M, Rahmani M, Kalantari-Hesari A, Nasiri E, Khosravi-Sadr M, Sabalani N et al . The effect of moderate intensity running training on reproductive system alteration induced by acetyl salicylic acid (Aspirin) in adult Wistar rats. Feyz. 2021; 25 (1) :732-742
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