History and Objectives: Hypotension during spinal anesthesia is a common complication and can cause sever morbidity and mortality. Due to repeated reports positive preventive effect of hemaccel and in order to compare the effect of colloidal and crystalloid intravenous infusion of hemaccel and Ringer solution and on prevention of hypotension during spinal anesthesia, the present study was carried out on patients referred to the Fatemieh hospital in the city of Hamedan.

Materials and Methods: A clinical trials was carried out on 100 patients who were scheduled for post partum tubal ligation with spinal anesthesia. Before anesthesia, heart beet and arterial blood pressure were recorded for all patients. All patients received spinal anesthesia and were randomly divided into two control and case groups. Hemaccel and Ringer (15 ml/Kg) were administered by venous perfusion to case and control, groups respectively. At 1, 5, 10, 15, 30 minutes intervals changes in heart beet and arterial blood pressure and further infusion of Ringer solution and infusion of ephedrine was recorded.

Results: 100 patients were equally divided into two groups and were matched for age and duration of surgery. Reduction in heartbeat was less in the case group compare to the control group and arterial blood pressure was 101 and 87 in the case and control group respectively. Need for Ringer solution was 8% and 80% in the case and control groups (P<0.005) and ephedrine requirement was 8% and 60% in the case and control groups respectively (P<0.0005).

Conclusion: In high-risk patients (Renal and cardiopulmonary patients), administration of low volume colloidal solution for the prevention of hypotension in the spinal anesthesia is recommended.