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:: Volume 22, Issue 3 (Bimonthly 2018) ::
Feyz 2018, 22(3): 274-282 Back to browse issues page
Evaluation of the simultaneous effect of zinc oxide nanoparticles and vitamin C on oxidative stress in rat cerebellum
Maryam Rafieirad * , Saeed Valipour-Chahardah-Charic
Department of Biology, Faculty of Basic Sciences, Izeh Branch, Islamic Azad University, Izeh, I. R. Iran. , rafieirad.m@gmail.com
Abstract:   (2749 Views)
Background: In recent years, the potential effects of nanoscale materials on the central nervous system have become even more noticeable. The cerebellum is one of the areas of the brain with high absorption of zinc. The aim of this study was to investigate the effects of zinc oxide nanoparticles (NPs) on oxidative stress indices in rat cerebellum in the presence and absence of vitamin C.
Materials and Methods: In this experimental study, male Wistar rats (250-200g) were divided into the following groups (n=7): a normal saline group (control), three groups that received different doses of zinc oxide NPs (1.25, 2.5 and 5 mg/kg), three groups that received different doses of vitamin ­C (30, 60 and 120 mg/kg) and three groups that received 1.25, 2.5 and 5 mg/kg of zinc oxide NPs combined with 30 mg/kg of vitamin­ C. Half an hour after receiving the medication, the rats were anesthetized and then their cerebellum was removed and the malondialdehyde (MDA) and thiol groups of the cerebellum region were measured.
Results: The MDA level decreased significantly in the groups received 5mg/kg of zinc oxide NPs, in the groups received different doses of vitamin­ C, and in the groups received different doses of zinc oxide NPs combined with 30 mg/kg vitamin­ C compared with the saline group. Total thiol concentration did not change significantly in the different study groups compared to the control group.
Conclusion: Zinc oxide NPs alone or in combination with vitamin C has a reduced effect on oxidative stress in the rat cerebellum.
Keywords: Zinc oxide NPs, Malondialdehyde, Thiol, Vitamin C, Rats
Full-Text [PDF 466 kb]   (734 Downloads)    
Type of Study: Research | Subject: General
Received: 2018/01/31 | Accepted: 2018/05/7 | Published: 2018/08/4
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Rafieirad M, Valipour-Chahardah-Charic S. Evaluation of the simultaneous effect of zinc oxide nanoparticles and vitamin C on oxidative stress in rat cerebellum. Feyz 2018; 22 (3) :274-282
URL: http://feyz.kaums.ac.ir/article-1-3525-en.html

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Volume 22, Issue 3 (Bimonthly 2018) Back to browse issues page
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