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:: Volume 22, Issue 3 (Bimonthly 2018) ::
Feyz 2018, 22(3): 283-291 Back to browse issues page
Evaluation of brain-derived neurotrophic factor expression and spatial memory after valproic acid administration in animal model of hippocampal degeneration
Mohammad Amin Edalatmanesh * , Mahtab Sheikholeslami , Samaneh Rafiei
Department of Biology, College of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, I. R. Iran. , amin.edalatmanesh@gmail.com
Abstract:   (3017 Views)
Background: Hippocampal neurodegeneration caused the incidence of cognitive deficits, along with a possible decrease of neurotrophins. Valproic acid (VPA) is a histone deacetylase inhibitor, which could protect the nervous system from neuronal degeneration through neurotrophic modifications. This study aimed to investigate the effect of different doses of VPA on a hippocampal brain-derived neurotrophic factor (BDNF) level, CA1 area of hippocampal histopathology, and spatial memory assessment in animal models of hippocampal degeneration.
Materials and Methods: To induce hippocampal degeneration, rats were injected intraperitoneally with trimethyltin (TMT). Three test groups (TMT+VPA) received 100, 200 and 400 mg/kg of VPA, respectively, and the TMT+Saline group received normal saline for 14 days after TMT intoxication. To investigate the spatial memory, the Morris water maze was used. Then, the BDNF hippocampal level was evaluated using the ELISA technique and histopathological evaluation of hippocampus was also done.
Results: Valproic acid decreased the distance and latency time to arrive the hidden platform in learning blocks and increased the spent time in the target quadrant in a probe test following TMT intoxication. Also, the BDNF hippocampal level and amelioration of cell damage in the CA1 area of the hippocampus significantly increased in VPA-treated groups compared with the TMT+Saline group.
Conclusion: Valproic acid has neuroprotective effects, which can decrease cognitive deficits due to TMT intoxication in rats.
Keywords: Brain-derived neurotrophic factor, Trimethyltin, Valproic acid, Spatial memory, Hippocampus, Rat
Full-Text [PDF 933 kb]   (1932 Downloads)    
Type of Study: Research | Subject: General
Received: 2017/12/4 | Accepted: 2018/07/22 | Published: 2018/08/4
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Edalatmanesh M A, Sheikholeslami M, Rafiei S. Evaluation of brain-derived neurotrophic factor expression and spatial memory after valproic acid administration in animal model of hippocampal degeneration. Feyz 2018; 22 (3) :283-291
URL: http://feyz.kaums.ac.ir/article-1-3487-en.html

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Volume 22, Issue 3 (Bimonthly 2018) Back to browse issues page
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