[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Indexing Sources::
Guide for Authors::
Online Submission::
Ethics::
Articles archive::
For Reviewers::
Contact us::
::
Basic and Clinical Biochemistry and Nutrition
..
DOAJ
..
CINAHL
..
EBSCO
..
IMEMR
..
ISC
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
enamad
..
:: Volume 14, Issue 3 (Quarterly 2010) ::
Feyz 2010, 14(3): 217-222 Back to browse issues page
The effects of different doses of folic acid on motor activity of rat
Maryam Khombi Shooshtari , Mohammad Ali Moazedi , Gholam Ali Parham
, shooshtari_m@yahoo.com
Abstract:   (7518 Views)

Background: Folic acid (folate) which is a water-soluble vitamin-B is essential for the life-sustaining processes of DNA synthesis, replication, repair, and also protein synthesis. Experimental evidence suggests that folate deficiency and its consequent elevated homocysteine level sensitize dopaminergic neurons to environmental toxin, whereby folate deficiency may influence risk of Parkinson disease. Accordingly, in this study, the effects of different doses of folic acid on motor activity of rat were studied using rotarod apparatus.

Materials and Methods: Animals were divided into four groups and were injected intraperitonealy a single dose of folic acid or vehicle/day for one week. The there test groups received 5, 10 and 15 mg/kg/day folic acid and the sham group received saline. Then, all groups were introduced to the rotarod test.

Results: The results showed that 5 mg/kg/day of folic acid significantly improves motor coordination (P<0.05).

Conclusion: Overally, the present results indicate that low-dose folic acid improves motor performance of the rats.

Keywords: Folic acid, Rotarod performance test, Locomotion, Rat
Full-Text [PDF 219 kb]   (2847 Downloads)    
Type of Study: Research | Subject: General
Received: 2010/09/28 | Revised: 2010/10/5 | Published: 2010/10/15
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Khombi Shooshtari M, Moazedi M A, Parham G A. The effects of different doses of folic acid on motor activity of rat. Feyz 2010; 14 (3) :217-222
URL: http://feyz.kaums.ac.ir/article-1-966-en.html


Creative Commons License
This open access journal is licensed under a Creative Commons Attribution-NonCommercial ۴.۰ International License. CC BY-NC ۴. Design and publishing by Kashan University of Medical Sciences.
Copyright ۲۰۲۳© Feyz Medical Sciences Journal. All rights reserved.
Volume 14, Issue 3 (Quarterly 2010) Back to browse issues page
مجله علوم پزشکی فیض Feyz Medical Sciences Journal
Persian site map - English site map - Created in 0.05 seconds with 46 queries by YEKTAWEB 4645