Background: Migraine headache is one of the most common causes of headache which influences on th quality of life and performance of the patients. Migraine headache has some co-morbidities like depression and anxiety. The aim of this study was to evaluate the frequency of panic attacks in migraine patients of Baqiyatallah Hospital in 2004.

Materials and Methods: In a cross-sectional study in Baqiyatallah Hospital, 85 patients who according to Internal Headache Society criteria had migraine headache, were evaluated for panic attack. Diagnosis of panic attack was made through interview and questionnaire according to DSM-IV criteria. T -Test and Chi-Square were used to analyze the data.

Results: The patients consisted of 23 males and 62 females. 41 patients (48.2%) had panic attacks 36 of whom were female. 29 patients were married. 27 patients (69%) with education of less than diploma, 10 patients (41%) with diploma and only 4 patients (18.2%) with education higher than diploma had panic attack (p<0.05).

Conclusion: The prevalence of panic attack in the patients with migraine is higher than what was expected (48.2%). The higher education, the less panic attack.