Background: Hydatidosis is one of the most prevalent zoonotic diseases worldwide caused by the metacestode form of Echinococcus granulosus. The diagnosis of cystic echinococcusis is difficult using the clinical features of the disease and serological methods help to determine the specific antibody response. Due to medical and economical importance of this disease, the aim of this study was to investigate the prevalence of the human hydatidosis among adults in Kashan, a central region of Iran, in 2008.

Materials and Methods: In a cross-sectional study, 361 serum samples were randomly collected from adult cases referring to the city and rural health centers of Kashan. All the sera in different age groups were examined using ELISA and IFA tests.

Results: The age Mean±SD in this study was 33.4±9.7 years. Only 11 cases (3.05 %) using both ELISA and IFA were positive for hydatidosis and the other cases were negative by two methods. The infection rate among males and females was 3.7% and 2.3%, respectively. There was no significant association between hydatidosis, sex and residency.

 Conclusion: According to the results, the rate of hydatidosis prevalence in this region was high justifying control programs of hydatidosis.