History and Objectives: Due to the prevalence of the disease in Kashan and the fact that the treatment by glucantime as a therapeutic agent is elective, this study was conducted to evaluate the side effects of the glucantime on liver and kidney. Hepatic enzyme profile and renal function test were performed on the patients suffering from cutaneous Leishmaniosis. The present study was done on such patients in 1995.

Materials and Methods: An experimental study was designed to assess the effect of glucantime therapy before and after treatment. A questionnaire pertaining to the age, sex, occupation and address of the patients was filled. Blood samples (5ml) were taken and hepatic enzymes (ALT, AST, ALP) and renal function test (BUN, Creatinine) were determined by Technicon RA-100 auto analyzer (Control group). Liver tests and renal function tests were done after 21 days of therapy by intramuscular injection of glucantime (60 mg/kg body weight/day) (Experimental group). Statistical paired t-test was conducted.

Results: 70 patients, 47 females (67.1%) and 23 males (32.9%) were followed in this study (Mean age: 26.3±7.9 intervals of 5-69). Therapeutic administration of glucantime altered the concentration of ALT 1.6±7.9 P<0.05) however it did not any effects on other tests (AST, ALP, BUN, Cre).

Conclusion: Therefore it is suggested that hepatic enzyme tests should be performed at intervals in order to prevent any hepatic damage.