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:: Volume 29, Issue 1 (Bimonthly 2025) ::
Feyz Med Sci J 2025, 29(1): 38-45 Back to browse issues page
The effect of aerobic exercise combined with Melissa officinalis extract on working memory, reference memory, and beta-amyloid deposition in the hippocampal tissue of induced Alzheimer’s male rats
Mahnaz Navardi , Ramin Shabani * , Shahram Gholamrezaeidarsara
Department of Physical Education and Sport Sciences, Rasht Branch, Islamic Azad University, Rasht, Iran & Department of Physical Education and Sport Sciences, Rasht Branch, Islamic Azad University, Rasht, Iran , dr.ramin.shabani@gmail.com
Abstract:   (554 Views)
Background and Aim: Alzheimer's disease is a progressive neurodegenerative disorder characterized by the gradual destruction of brain tissue and the onset of severe cognitive impairments. The present study aimed to evaluate the effects of aerobic exercise combined with Melissa officinalis extract on working memory, reference memory, and beta-amyloid deposition in the hippocampal tissue of induced Alzheimer’s male rats.
Methods: In this experimental study, 32 adult male rats were randomly assigned to four groups: control, aerobic exercise, aerobic exercise combined with the extract, and extract alone. The Alzheimer's model was induced by intrahippocampal injection of beta-amyloid 1-42. The exercise protocol was conducted for 8 weeks, with three sessions per week. Working memory was assessed using the eight-arm maze test, and beta-amyloid deposition in the hippocampus was quantified by the ELISA method.
Results: Working memory performance in the intervention groups (aerobic exercise, exercise with extract, and extract alone) showed significant improvement compared to the control group (P<0.05). Additionally, beta-amyloid deposition in the hippocampus was significantly reduced in these groups (P<0.05).
Conclusion: Aerobic exercise and Melissa officinalis extract appear to play a significant role in improving working memory performance in male rats with Alzheimer's disease by reducing beta-amyloid deposition. However, further studies are necessary to confirm these findings.
Keywords: Aerobic exercise, Melissa officinalis, Alzheimer’s, Working memory, Beta-amyloid
Full-Text [PDF 442 kb]   (99 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2024/12/10 | Revised: 2025/04/27 | Accepted: 2025/02/23 | Published: 2025/04/22
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Navardi M, Shabani R, Gholamrezaeidarsara S. The effect of aerobic exercise combined with Melissa officinalis extract on working memory, reference memory, and beta-amyloid deposition in the hippocampal tissue of induced Alzheimer’s male rats. Feyz Med Sci J 2025; 29 (1) :38-45
URL: http://feyz.kaums.ac.ir/article-1-5282-en.html


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Volume 29, Issue 1 (Bimonthly 2025) Back to browse issues page
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