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Epidemiology of Perforated Peptic Ulcer and It’s Risk Factors: Report of 80 Cases from Beheshti Hospital in Kashan
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Nushin Moussavi-Biuki *    , Ehsan Amiri , Hamidreza Gilasi , Mehdi Rajabi |
| Kashan University of Medical Sciences , n.moussavi@yahoo.com |
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Abstract: (86 Views) |
Introduction: Peptic ulcer disease is prevalent all over the world and in all ages. Ulcer perforation occurs in approximately 5% of patients, leading to morbidity and mortality. The aim of this study was the evaluation of demographic data of patients with perforated peptic ulcer in Kashan, Iran.
Patients and Methods: For this case series study, all patients who underwent operation with the diagnosis of perforated peptic ulcer from March 2017 to February 2021 in Beheshti Hospital, Kashan (Iran) were included. Demographic data including age and sex, site of perforation (stomach or duodenum) and underlying risk factors for peptic ulcer were documented. Data analysis was performed using SPSS statistics for Windows, version 26.
Results: Eighty patients were included. Mean age was 48.25 ± 18.59 and 44 patients (55%) were female. The most common risk factors were smoking (57.5%), chronic use of non-steroidal anti-inflammatory drugs (47.5%) and drug abuse (28.7%). Underlying cardiovascular disease was present in 47.5% of patients. Duodenum was the most common site of perforation (73.8%).
Conclusion: The number of female patients with perforated peptic ulcer was higher than males in our study, in discordance to other studies all over the world, which report a higher prevalence in men. This finding might be due to lower smoking and alcohol consume in men or higher NSAID or aspirin consumption in the study population. Rationale use of drugs and using ulcer prophylaxis in high-risk patients should be encouraged. |
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| Keywords: peptic ulcer perforation, design, epidemiologic research |
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Type of Study: Research |
Subject:
medicine, paraclinic
Received: 2024/10/21 | Revised: 2025/05/27 | Accepted: 2025/05/27
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