Epidemiology of perforated peptic ulcer: A report of 80 cases from Shahid Beheshti Hospital, Kashan, Iran

Moussavi-Biuki, Nushin; Amiri, Ehsan; Gilasi, Hamidreza; Rajabi, Mehdi

doi:10.48307/FMSJ.2025.29.2.185

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Volume 29, Issue 2 (Bimothly 2025)

Feyz Med Sci J 2025, 29(2): 183-188

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Epidemiology of perforated peptic ulcer: A report of 80 cases from Shahid Beheshti Hospital, Kashan, Iran

Nushin Moussavi-Biuki ^*

, Ehsan Amiri

, Hamidreza Gilasi

, Mehdi Rajabi

Trauma Research Center, Kashan University of Medical Sciences, Kashan, Iran , n.moussavi@yahoo.com

Abstract: (413 Views)

Background and Aim: Peptic ulcer disease is a common condition worldwide, affecting individuals across all age groups. Approximately 5% of patients with peptic ulcers develop perforation during their lifetime, which can lead to serious complications and even mortality. This study aimed to determine the demographic characteristics of patients diagnosed with perforated peptic ulcer at Shahid Beheshti Hospital in Kashan.
Methods: In this case series study, we examined all patients who underwent surgery for perforated peptic ulcer at Shahid Beheshti Hospital in Kashan between 2017 and 2022 (1396-1401 SH). Data including age, sex, perforation site (stomach or duodenum), and underlying factors were extracted from medical records through census method and analyzed using SPSS version 26.
Results: Among 80 patients with perforated peptic ulcer, 73.8% had duodenal perforation (mean age: 47.8 years) and 26.3% had gastric perforation (mean age: 49.4 years). In the duodenal group, smoking (66.1% vs 47.6%) and drug abuse (32.2% vs 19%) were more prevalent compared to the gastric group, while other factors such as NSAID use, steroid use, and cardiovascular disease were similar between the two groups. Female patients outnumbered males in both groups.
Conclusion: Contrary to similar studies, our findings showed a higher prevalence of perforated peptic ulcer among women compared to men in our population. This may be attributed to lower rates of smoking and alcohol consumption among men in our region compared to other countries, along with higher consumption of non-steroidal anti-inflammatory drugs or aspirin in the studied population.

Keywords: Peptic ulcer perforation, Duodenum, Non-steroidal anti-inflammatory drugs, Risk factors, Epidemiology

Full-Text [PDF 334 kb] (67 Downloads)

Type of Study: Research | Subject: medicine, paraclinic
Received: 2024/10/21 | Revised: 2025/07/8 | Accepted: 2025/05/27 | Published: 2025/07/1

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Moussavi-Biuki N, Amiri E, Gilasi H, Rajabi M. Epidemiology of perforated peptic ulcer: A report of 80 cases from Shahid Beheshti Hospital, Kashan, Iran. Feyz Med Sci J 2025; 29 (2) :183-188
URL: http://feyz.kaums.ac.ir/article-1-5249-en.html

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