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:: Volume 28, Issue 6 (Bimonthly 2024) ::
Feyz Med Sci J 2024, 28(6): 622-630 Back to browse issues page
Evaluation of serum levels of cell adhesion molecules (ICAM-1) and vascular adhesion molecules (VCAM-1) following a resistance training program in middle-aged and elderly men with hypertension
Bizhan Hooshmand Moghadam , Shadi Moazamigoudarzi , Amir Rashidlamir , Babak Hooshmand-Moghadam *
Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran & Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran , b.hooshmand@um.ac.ir
Abstract:   (747 Views)
Background and Aim: Cell adhesion molecules (ICAM-1) and vascular adhesion molecules (VCAM-1) play critical roles in endothelial function and cardiovascular diseases. Given the increasing use of resistance training among middle-aged and elderly individuals, it is essential to examine the effects of this type of exercise on the serum levels of these molecules. The aim of this study was to evaluate the effect of 12 weeks of resistance training on serum levels of ICAM-1 and VCAM-1 in middle-aged and elderly men with hypertension.
Methods: This quasi-experimental study involved 24 elderly men with hypertension who met the inclusion criteria. Participants were randomly assigned to either the resistance training group (12 participants) or the control group (12 participants). The resistance training group performed resistance exercises three times a week for 12 weeks. Blood samples were collected at baseline and at the end of the study to measure serum levels of ICAM-1 and VCAM-1.
Results: After 12 weeks of resistance training, serum levels of ICAM-1 (P=0.003) and VCAM-1 (P=0.005) significantly decreased. Additionally, inter-group comparisons showed significant differences in mean changes for both ICAM-1 (P=0.001) and VCAM-1 (P=0.001).
Conclusion: Long-term resistance training appears to be effective not only in improving systolic and diastolic blood pressure but also in reducing serum levels of ICAM-1 and VCAM-1 in middle-aged and elderly men with hypertension. Therefore, regular resistance training may serve as a potential non-pharmacological approach for reducing blood pressure and improving endothelial function in this population.

 
Keywords: Blood pressure, Resistance training, Cell adhesion molecules, Vascular adhesion molecules
Full-Text [PDF 451 kb]   (241 Downloads)    
Type of Study: Research | Subject: General
Received: 2024/03/12 | Revised: 2025/03/3 | Accepted: 2024/12/10 | Published: 2025/02/5
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Hooshmand Moghadam B, Moazamigoudarzi S, Rashidlamir A, Hooshmand-Moghadam B. Evaluation of serum levels of cell adhesion molecules (ICAM-1) and vascular adhesion molecules (VCAM-1) following a resistance training program in middle-aged and elderly men with hypertension. Feyz Med Sci J 2024; 28 (6) :622-630
URL: http://feyz.kaums.ac.ir/article-1-5142-en.html


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Volume 28, Issue 6 (Bimonthly 2024) Back to browse issues page
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