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:: Volume 28, Issue 1 (Bimothly 2024) ::
Feyz Med Sci J 2024, 28(1): 58-67 Back to browse issues page
The effect of eight weeks of high-intensity interval and moderate-intensity continuous training with quercetin supplementation on the expression of PGC1-α and NRF-1 genes in the heart tissue of obese diabetic male rats
Mojdeh Khajehlandi * , Lotfali Bolboli
Department of Exercise Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran , mojdeh.khajehlandi@gmail.com
Abstract:   (459 Views)
Background and Aim: Diabetes is more prevalent in obese individuals compared to non-obese individuals. This study aimed to examine the effects of eight weeks of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) combined with quercetin supplementation on the gene expression levels of peroxisome gamma coactivator alpha-1 (PGC1-α) and nuclear respiratory factor-1 (NRF-1) in the heart tissue of obese male diabetic rats.
Methods: In this experimental study, 35 male rats were randomly assigned to seven groups of five: Diabetic control, healthy control, quercetin control, HIIT, MICT, HIIT with quercetin, and MICT with quercetin. The training protocols were conducted daily for eight weeks. Additionally, intraperitoneal injections of quercetin (15 mg/kg) were administered for eight weeks (5 days in each week) in the supplement groups. The expression levels of PGC1-α and NRF-1 genes in rat heart tissue were assessed using the qRT-PCR method.
Results: Following the 8-week intervention, a significant decrease in blood glucose levels was observed in the quercetin control group and the four other training groups (P<0.05). Moreover, the expression levels of PGC1-α and NRF-1 genes in the heart tissue of rats significantly increased in both the training groups with and without quercetin supplementation (P<0.05).
Conclusion: The findings of the present study indicate that the combination of quercetin injection with HIIT and MICT resulted in a significant increase in the expression levels of PGC1-α and NRF-1 genes in the heart tissue of rats, along with effective blood glucose level control.
Keywords: High-intensity interval training (HIIT), Moderate-intensity continuous training (MICT), Quercetin, Diabetes
Full-Text [PDF 665 kb]   (216 Downloads)    
Type of Study: Research | Subject: General
Received: 2023/11/14 | Revised: 2024/05/1 | Accepted: 2024/02/6 | Published: 2024/03/13
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Khajehlandi M, Bolboli L. The effect of eight weeks of high-intensity interval and moderate-intensity continuous training with quercetin supplementation on the expression of PGC1-α and NRF-1 genes in the heart tissue of obese diabetic male rats. Feyz Med Sci J 2024; 28 (1) :58-67
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Volume 28, Issue 1 (Bimothly 2024) Back to browse issues page
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