[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Indexing Sources::
Guide for Authors::
Online Submission::
Ethics::
Articles archive::
For Reviewers::
Contact us::
AI::
::
Basic and Clinical Biochemistry and Nutrition
..
DOAJ
..
CINAHL
..
EBSCO
..
IMEMR
..
ISC
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
enamad
..
:: Volume 28, Issue 1 (Bimothly 2024) ::
Feyz Med Sci J 2024, 28(1): 96-109 Back to browse issues page
Comparison of the effects of high-intensity intermittent training and moderate-intensity continuous training on cardiometabolic factors in type 2 diabetic patients: a systematic review and meta-analysis
Fatemeh Kazemi Nesab * , Omid Zafarmand
Department of Physical Education and Sport Sciences, Faculty of Humanities, University of Kashan, Kashan, Iran , fkazeminasab@kashanu.ac.ir
Abstract:   (1466 Views)
Background and Aim: Lifestyle interventions, including various types of exercise, are considered beneficial in managing type 2 diabetes. This systematic review and meta-analysis aimed at comparing the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on cardiometabolic factors in type 2 diabetes.
Methods: A systematic search of English and Farsi papers published in PubMed, Web of Science, Scopus, SID, and Magiran databases was conducted until August 2023. The search utilized keywords such as "high-intensity interval training (HIIT)", "moderate-intensity continuous exercise (MICT)", "cardiometabolic factors", and "type 2 diabetes". A meta-analysis was performed to compare the impact of HIIT and MICT training on cardiometabolic factors in type 2 diabetes. Mean differences and 95% confidence intervals (CI) were calculated using a random-effects model. Heterogeneity was assessed using the I2 test, and publication bias was evaluated through the visual analysis of funnel plots and Egger's test.
Results: Analysis of 10 studies comprising 11 sports interventions involving 271 individuals with type 2 diabetes revealed that HIIT led to a significant reduction in fasting insulin [SMD=-0.93 (-1.25 to -0.6), P=0.001], HOMA-IR [WMD=-0.73 (-1.03 to -0.43), P=0.001], and systolic blood pressure [WMD=-3.15 mmHg (-6.29 to -0.01), P=0.04] compared to MICT in patients with type 2 diabetes. However, there were no significant differences in fasting glucose [WMD=-2.91 mg/dL (-7.97 to 2.14), P=0.2], diastolic blood pressure [WMD=0.3 mmHg (-0.77 to 1.56), P=0.5], and maximum oxygen consumption [SMD=0.49 (-0.004 to 0.99), P=0.05] between HIIT and MICT exercises in patients with type 2 diabetes.
Conclusion: HIIT appears to be a favorable training method with efficient outcomes for improving cardiometabolic factors in patients with type 2 diabetes compared to MICT.

 
Keywords: High-intensity interval training, Moderate-intensity continuous training, Type 2 diabetes, Blood pressure resistance
Full-Text [PDF 580 kb]   (916 Downloads)    
Type of Study: Review | Subject: medicine, paraclinic
Received: 2023/10/5 | Revised: 2024/05/1 | Accepted: 2024/01/22 | Published: 2024/03/13
References
1. Ansari S, Djalali M, Honarvar NM, Mazaherioun M, Zarei M, Gholampour Z, et al. Assessing the effect of omega-3 fatty acids supplementation on serum BDNF (Brain derived Neurotrophic factor) in patients with type 2 diabetes: a randomized , double-blind, placebo-controlled study. Intl Res J Appl Basic Sci. 2016. doi:10.5812/ijem.40614 PMid:28835761 PMCid:PMC5554612
2. Kazeminasab F, Baharlooie M, Rezazadeh H, Soltani N, Rosenkranz SK. The effects of aerobic exercise on liver function, insulin resistance, and lipid profiles in prediabetic and type 2 diabetic mice. Physiol Behav. 2023; 114340. doi:10.1016/j.physbeh.2023.114340 PMid:37648184
3. Gomez-Perez FJ, Aguilar-Salinas CA, Almeda-Valdes P, Cuevas-Ramos D, Lerman Garber I, Rull JA. HbA1c for the diagnosis of diabetes mellitus in a developing country. A position article. Arch Med Res. 2010; 41(4): 302-8. doi:10.1016/j.arcmed.2010.05.007 PMid:20637376
4. Tabák AG, Herder C, Rathmann W, Brunner EJ, Kivimäki M. Prediabetes: a high-risk state for diabetes development. Lancet. 2012; 379(9833): 2279-90. doi:10.1016/S0140-6736(12)60283-9 PMid:22683128
5. Niyonkuru, V. Computational Fluid Dynamics (CFD) for blood flow in cardiovascular medical devices and blood damage prediction. Novel Clin Med 2023;2(3):136-142. doi: 10.22034/ncm.2023.408048.1101
6. Pinent M, Castell A, Baiges G, Montagut G, Arola L, Ardévol A. Bioactivity of Flavonoids on Insulin-Secreting Cells. Compr Rev Food Sci Food Saf, 2008. 7(4): 299-308. doi:10.1111/j.1541-4337.2008.00048.x PMid:33467792
7. Kazeminasab F, Marandi SM, Baharlooie M, Nasr-Esfahani MH, Ghaedi K. Modulation and bioinformatics screening of hepatic mRNA-lncRNAs (HML) network associated with insulin resistance in prediabetic and exercised mice. Nutr Metab. 2021; 18(1): 1-16. doi:10.1186/s12986-021-00600-0 PMid:34284789 PMCid:PMC8290563
8. Teodoro JS, Gomes AP, Varela AT, Duarte FV, Rolo AP, Palmeira CM. Uncovering the beginning of diabetes: the cellular redox status and oxidative stress as starting players in hyperglycemic damage. Mol Cell Biochem. 2013; 376(1-2): 103-10. doi:10.1007/s11010-012-1555-9 PMid:23292031
9. Li G, Zhang P, Wang J, Gregg EW, Yang W, Gong Q, Li H, et al. The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study. Lancet. 2008; 371(9626): 1783-9. doi:10.1016/S0140-6736(08)60766-7 PMid:18502303
10. Nasiri R, Meshkati Z, Nasiri S. Regular aerobic/resistance exercises and garlic extract supplementation effects in pregnancy outcome of Balb/C mice. J Appl Health Stud Sport Physiol. 2017; 4(2): 89-96.
11. Larsen S, Danielsen JH, Søndergård SD, Søgaard D, Vigelsoe A, Dybboe R, et al. The effect of high-intensity training on mitochondrial fat oxidation in skeletal muscle and subcutaneous adipose tissue. Scand J Med Sci Sports. 2015; 25(1): e59-69. doi:10.1111/sms.12252
12. Fazel Najafabadi Z, Azamian Jazi A, Banitalebi E. Effect of Eight Weeks High Intensity Interval Training (HIIT) and Combined Training on Serum Liver Enzymes and Insulin Resistance Index in Women with Type 2 Diabetes. North Khorasan Univ Med Sci. 2020. 11(4): 28-35. doi:10.52547/nkums.11.4.28
13. Little JP, Gillen JB, Percival ME, Safdar A, Tarnopolsky MA, Punthakee Z, et al. Low-volume high-intensity interval training reduces hyperglycemia and increases muscle mitochondrial capacity in patients with type 2 diabetes. J Appl Physiol (1985). 2011; 111(6): 1554-60. doi:10.1152/japplphysiol.00921.2011 PMid:21868679
14. Kazeminasab F, Sharafifard F, Mohebinejad M. Comparing the Effects of High-Intensity Interval Training and Moderate-Intensity Continuous Training on Body Composition in Adults with Overweight and Obese: A Systematic Review and Meta-Analysis. J Isfahan Medical Sch. 2023; 41(721): 406-26.
15. Naderi L, Banaei Borojeni J, Kargarfard M, Keshavarz S. Comparison of Interval and Continuous Training on Growth Differentiation Factor 15, Pancreatic beta cell function and insulin resistance in Women with Type 2 Diabetes. Med J Mashhad Univ Med Sci. 2021; 64(2): 2681-91.
16. Najafi M, Ghazalian F, Gaeini A, Natanzi HA, Gholami M. Comparative effects of 12-week interval and continuous trainings on some vasodilation and vasoconstriction factors in patients with type 2 diabetes. Sci J Rehabil Med. 2020; 9(4): 322-332.
17. Peng Y, Ou Y, Wang K, Wang Z, Zheng X. The effect of low volume high-intensity interval training on metabolic and cardiorespiratory outcomes in patients with type 2 diabetes mellitus: A systematic review and meta-analysis. Front Endocrinol (Lausanne). 2022; 13: 1098325. doi:10.3389/fendo.2022.1098325 PMid:36686490 PMCid:PMC9845913
18. Jelleyman C, Yates T, O'Donovan G, Gray LJ, King JA, Khunti K. et al. The effects of high-intensity interval training on glucose regulation and insulin resistance: a meta-analysis. Obes Rev. 2015; 16(11): 942-61. doi:10.1111/obr.12317 PMid:26481101
19. Kubli DA, Gustafsson AB. Mitochondria and mitophagy: the yin and yang of cell death control. Circ Res. 2012; 111(9): 1208-21. doi:10.1161/CIRCRESAHA.112.265819 PMid:23065344 PMCid:PMC3538875
20. Souri R, Khosravi N, Yazdan Dost H, Aiti MH. A Comparison of Moderate Intensity Continuous Training and High Intensity Interval Training on Serum Levels of Resistin and Insulin Resistance in Type-2 Diabetic Obese Women. J Sport Biosci. 2016; 8(3): 365-80.
21. Khalafi M, Malandish A, Rosenkranz SK, Ravasi AA. Effect of resistance training with and without caloric restriction on visceral fat: A systemic review and meta-analysis. Obes Rev. 2021; 22(9): e13275. doi:10.1111/obr.13275 PMid:33998135
22. Kazeminasab F, Sharafifard F, Miraghajani M, Behzadnejad N, Rosenkranz SK. The effects of exercise training on insulin resistance in children and adolescents with overweight or obesity: a systematic review and meta-analysis. Front Endocrinol. 2023; 1178376. doi:10.3389/fendo.2023.1178376 PMid:37635963 PMCid:PMC10450243
23. Khalafi M, Azali Alamdari K, Symonds ME, Nobari H, Carlos-Vivas J. Impact of acute exercise on immediate and following early post-exercise FGF-21 concentration in adults: systematic review and meta-analysis. Hormones (Athens). 2021; 20(1): 23-33. doi:10.1007/s42000-020-00245-3 PMid:33151509
24. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997; 315(7109): 629-34. doi:10.1136/bmj.315.7109.629 PMid:9310563 PMCid:PMC2127453
25. Bayat Z, Gaeini A, Nuri R. Comparative Effect of interval, continuous, and combined aerobic exercise on cardiovascular disease risk factors in Type 2 Diabetic patients with fatty liver. Pejouhesh dar Pezeshki (Research in Medicine). 2021; 45(1): 8-14.doi:10.34172/mj.2021.071
26. Oliveira BRR, Slama FA, Deslandes AC, Furtado ES, Santos TM. Continuous and high-intensity interval training: which promotes higher pleasure? PLoS One. 2013; 8(11): e79965. doi:10.1371/journal.pone.0079965 PMid:24302993 PMCid:PMC3841165
27. Gentil P, Bento E Silva LR, Antunes DE, Barbosa Carneiro L, Barbosa de Lira CA, Batista G, et al. The effects of three different low-volume aerobic training protocols on cardiometabolic parameters of type 2 diabetes patients: A randomized clinical trial. Front Endocrinol. 2023; 985404. doi:10.3389/fendo.2023.985404 PMid:36755928 PMCid:PMC9900112
28. Li J, Cheng W, Ma H. A Comparative Study of Health Efficacy Indicators in Subjects with T2DM Applying Power Cycling to 12 Weeks of Low-Volume High-Intensity Interval Training and Moderate-Intensity Continuous Training. J Diabetes Res. 2022; 2022: 9273830. doi:10.1155/2022/9273830 PMid:35071605 PMCid:PMC8776485
29. Hwang CL, Lim J, Yoo JK, Kim HK, Hwang MH, Handberg EM. Effect of all-extremity high-intensity interval training vs. moderate-intensity continuous training on aerobic fitness in middle-aged and older adults with type 2 diabetes: A randomized controlled trial. Exp Gerontol. 2019; 116: 46-53. doi:10.1016/j.exger.2018.12.013 PMid:30576716 PMCid:PMC6404965
30. Maillard F, Rousset S, Pereira B, Traore A, Pradel Del Amaze PD, Boirie Y, et al. High-intensity interval training reduces abdominal fat mass in postmenopausal women with type 2 diabetes. Diabetes Metab. 2016; 42(6): 433-41. doi:10.1016/j.diabet.2016.07.031 PMid:27567125
31. Karstoft K, Winding K, Knudsen SH, Nielsen JS, Thomsen C, Pedersen BK, et al. The effects of free-living interval-walking training on glycemic control, body composition, and physical fitness in type 2 diabetic patients: a randomized, controlled trial. Diabetes Care. 2013; 36(2): 228-36. doi:10.2337/dc12-0658 PMid:23002086 PMCid:PMC3554285
32. Mitranun W, Deerochanawong C, Tanaka H, Suksom D. Continuous vs interval training on glycemic control and macro- and microvascular reactivity in type 2 diabetic patients. Scand J Med Sci Sports. 2014; 24(2): e69-76.doi:10.1111/sms.12112 PMid:24102912
33. Torabi M, Mirzaei B. The effects of high intensity interval and moderate intensity aerobic continuous training on some of the glycemic control variables and fetuin-A in type 2 diabetic patients. J Sport Exercise Physiol. 2022; 15(3): 81-90. doi:10.52547/joeppa.15.3.81
34. Terada T, Friesen A, Chahal BS, Bell GJ, McCargar LJ, Boulé NG. Feasibility and preliminary efficacy of high intensity interval training in type 2 diabetes. Diabetes Res Clin Pract. 2013; 99(2): 120-9. doi:10.1016/j.diabres.2012.10.019 PMid:23183390
35. Guiraud T, Nigam A, Gremeaux V, Meyer P, Juneau M, Bosquet L. High-intensity interval training in cardiac rehabilitation. Sports Med. 2012; 42(7): 587-605. doi:10.2165/11631910-000000000-00000 PMid:22694349
36. Ghafari M, Faramarzi M, Banitalebi E. Comparison Effect of Continuous and Interval Training on Glycemic Factors in Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis of Internal Articles. Sport Physiol. 2021; 13(51): 17-42.
37. Grace A, Chan E, Giallauria F, Graham PL, Smart NA. Clinical outcomes and glycaemic responses to different aerobic exercise training intensities in type II diabetes: a systematic review and meta-analysis. Cardiovasc Diabetol. 2017; 16(1): 37. doi:10.1186/s12933-017-0518-6 PMid:28292300 PMCid:PMC5351065
38. Wisløff U, Støylen A, Loennechen JP, Bruvold M, Rognmo Ø, Haram PM, et al. Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study. Circulation. 2007; 115(24): 3086-94. doi:10.1161/CIRCULATIONAHA.106.675041 PMid:17548726
39. Azari N, Rahmati M, Fathi M. The effects of endurance exercise on blood gluocse, insulin and insulin resistance in patients with type II diabetes: Asystematic review and meta-analysis of studies in Iran. Iran J Diabetes Lipid Disord; 2018; 17(2): 65-78.
40. Nardi ATD, Tolves T, Lenzi TL, Signori LU, Vargas da Silva AM. High-intensity interval training versus continuous training on physiological and metabolic variables in prediabetes and type 2 diabetes: A meta-analysis. Diabetes Res Clin Pract. 2018; 137: 149-59. doi:10.1016/j.diabres.2017.12.017 PMid:29329778
41. Lora-Pozo I, Lucena-Anton D, Salazar A, Galán-Mercant A, Moral-Munoz JA. Anthropometric, Cardiopulmonary and Metabolic Benefits of the High-Intensity Interval Training Versus Moderate, Low-Intensity or Control for Type 2 Diabetes: Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2019; 16(22). doi:10.3390/ijerph16224524 PMid:31731764 PMCid:PMC6887993
42. Pavkov ME, Bennett PH, Knowler WC, Krakoff J, Sievers ML, Nelson RG. Effect of youth-onset type 2 diabetes mellitus on incidence of end-stage renal disease and mortality in young and middle-aged Pima Indians. JAMA. 2006; 296(4): 421-6. doi:10.1001/jama.296.4.421 PMid:16868300
43. Hidari H. The effect of short-term aerobic exercise on the blood pressure in elderly clients with hypertension. Med Surg Nurs J. 2014; 3(1): e87735.
44. Halliwill JR, Taylor JA, Eckberg DL. Impaired sympathetic vascular regulation in humans after acute dynamic exercise. J Physiol. 1996; 495 (Pt 1)(Pt 1): 279-88. doi:10.1113/jphysiol.1996.sp021592 PMid:8866370 PMCid:PMC1160743
45. Boulé NG, Haddad E, Kenny GP, Wells GA, Sigal RJ. Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials. JAMA. 2001; 286(10): 1218-27.doi:10.1001/jama.286.10.1218 PMid:11559268
46. Misra A, Alappan NK, Vikram KN, Goel K, Gupta N, Mittal K, et al. Effect of supervised progressive resistance-exercise training protocol on insulin sensitivity, glycemia, lipids, and body composition in Asian Indians with type 2 diabetes. Diabetes Care. 2008; 31(7): 1282-7. doi:10.2337/dc07-2316 PMid:18316394 PMCid:PMC2453659
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Kazemi Nesab F, Zafarmand O. Comparison of the effects of high-intensity intermittent training and moderate-intensity continuous training on cardiometabolic factors in type 2 diabetic patients: a systematic review and meta-analysis. Feyz Med Sci J 2024; 28 (1) :96-109
URL: http://feyz.kaums.ac.ir/article-1-5008-en.html


Creative Commons License
This open access journal is licensed under a Creative Commons Attribution-NonCommercial ۴.۰ International License. CC BY-NC ۴. Design and publishing by Kashan University of Medical Sciences.
Copyright ۲۰۲۳© Feyz Medical Sciences Journal. All rights reserved.
Volume 28, Issue 1 (Bimothly 2024) Back to browse issues page
مجله علوم پزشکی فیض Feyz Medical Sciences Journal
Persian site map - English site map - Created in 0.06 seconds with 44 queries by YEKTAWEB 4710