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:: Volume 27, Issue 6 (Bimonthly 2023) ::
Feyz 2023, 27(6): 696-702 Back to browse issues page
Etiology and clinical features of precocious puberty in children referred to the endocrinology clinic of Kashan University of Medical Sciences, Iran
Kobra Shiasi arani , Seid mohammad Enayati Arani , Hamidreza Gilasi
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran , kobra.shiasi@gmail.com
Abstract:   (234 Views)
Background and Aim: Precocious puberty presents a variety of causes and clinical features, with its prevalence on the rise. This study aimed at investigating the etiology and clinical characteristics of precocious puberty in children referred to the endocrinology clinic of Kashan University of Medical Sciences, Iran.
Methods: In this retrospective study, the medical records of children diagnosed with precocious puberty who attended the pediatric endocrinology clinic at Kashan University of Medical Sciences, Iran, between 2007 and 2014, were retrospectively reviewed. A comprehensive history and clinical examination were conducted by a pediatric endocrinologist, along with left hand X-rays and specific hormonal tests.
Results: Among the 357 children meeting the inclusion criteria, only two were boys, one with isolated adrenarche and the other with central precocious puberty. Out of the 355 girls, 315 (88.2%) had central precocious puberty, 19 (5.3%) presented with premature thelarche, 20 (5.6%) exhibited pubarche, and three (0.8%) had transient thelarche. Only 172 children maintained regular follow-up visits, with an average follow-up duration of 23±16 months. Of these, 42 were undergoing treatment, while 130 were monitored for the progression of puberty and the necessity for intervention. Over a 3-6-month period, no change in pubertal stage was observed in 49.6% of children, while 42.6% progressed in thelarche or pubarche, and 7.8% advanced in both pubarche and thelarche. Additionally, 24.8% of children experienced a height growth rate exceeding the 97th percentile.
Conclusion: Central precocious puberty emerged as the predominant cause of precocious puberty symptoms in this study. Furthermore, more than half of girls with true precocious puberty displayed a slow progressive course that did not warrant therapeutic interventions.
Keywords: Precocious puberty, Thelarche, Pubarche, Adrenarche
Full-Text [PDF 413 kb]   (72 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2022/12/21 | Revised: 2024/02/20 | Accepted: 2023/11/8 | Published: 2024/02/13
References
1. Jaruratanasirikul S, Thaiwong M. Etiologies of precocious puberty: 15-year experience in a tertiary hospital in southern Thailand. Pediatr Endocrinol Metab. 2010;23(12):1263-71. doi:10.1515/jpem.2010.200 PMid:21714460
2. Laube C, Fuhrmann D. Is early good or bad? Early puberty onset and its consequences for learning. Curr Opinion Behav Sci. 2020; 36: 150-6 doi:10.1016/j.cobeha.2020.10.005
3. Shiva S, Fayyazi A, Melikian A. Causes and types of precocious puberty in North-West Iran. Iran J Pediatr. 2012; 22(4):487-92.
4. Fuqua JS. Treatment and outcomes of precocious puberty: An update. J Clin Endocrinol Metab. 2013;98(6): 2198-207. doi:10.1210/jc.2013-1024 PMid:23515450
5. Kim D, Cho SY, Maeng SH, Yi ES, Jung YJ, Park SW, et al. Diagnosis and constitutional and laboratory features of Korean girls referred for precocious puberty. Korean J Pediatr. 2012; 55(12): 481-6. doi:10.3345/kjp.2012.55.12.481 PMid:23300504 PMCid:PMC3534162
6. Kim EY, Lee MI. Psychosocial aspects in girls with idiopathic precocious puberty. Psychiatry Investig. 2012; 9 (1):25-8.doi:10.4306/pi.2012.9.1.25 PMid:22396681 PMCid:PMC3285737
7. Antunes Franzini I, Massahito Yamamoto F, Bolfi F, Rauber Antonini SR, Nunes‐Nogueira VdS. Comments on'Adult height after gonadotropin‐releasing hormone agonist treatment in girls with early puberty: A meta‐analysis. Clin Endocrinol. 2020; 93(4): 511-4. doi:10.1111/cen.14292 PMid:33464581
8. Williams VSL, Soliman AM, Barrett AM, Klein KO. Review and evaluation of patient-centered psychosocial assessments for children with central precocious puberty or early puberty. J Pediatric Endocrinol Metabol. 2018;31(5): 485-95. doi:10.1515/jpem-2017-0465 PMid:29649000
9. Mercader-Yus E, Neipp-Lopez MC, Gomez-Mendez P, Vargas-Torcal F, Gelves-Ospina M, Puerta-Morales L, et al. Anxiety, Self-esteem and Body Image in Girls with Precocious Puberty. Rev Colomb Psiquiatr (Engl Ed). 2018;47(4):229-36. doi:10.1016/j.rcpeng.2017.05.015 PMid:30286845
10. Sultan C, Gaspari L, Kalfa N, Paris F. Clinical expression of precocious puberty in girls. In: Sultan C, editor. 2012. p. 84-100 doi:10.1159/000334304 PMid:22846523
11. Soriano-Guillen L, Argente J. Central precocious puberty: epidemiology, etiology, diagnosis and treatment An Pediatr (Barc). 2011;74(5):336.e1-336.e13. doi:10.1016/j.anpedi.2010.11.003 PMid:21334274
12. de Vries L, Guz-Mark A, Lazar L, Reches A, Phillip M. Premature Thelarche: Age at Presentation Affects Clinical Course but Not Clinical Characteristics or Risk to Progress to Precocious Puberty. J Pediatr. 2010; 156(3):466-71.doi:10.1016/j.jpeds.2009.09.071 PMid:19914634
13. Rohani F, Salehpur S, Safari F. Etiology of precocious puberty, 10 years study in Endocrine Reserch Centre (Firouzgar), Tehran. Iran J Reproductive Med. 2012;10(1): 1-6.
14. Pourhaji F, Delshad MH, Khorasani N. Impact of family-centered study: the theory-based intervention to increase preventive behaviors iron deficiency anemia on the primary students: A randomized controlled trial protocol. Novel Clin Med 2023; 2(2): 111-119. doi: 10.22034/ncm.2023.380641.1063
15. Brito VN, Latronico AC, Cukier P, Teles MG, Silveira LF, Arnhold IJ, et al. Factors determining normal adult height in girls with gonadotropin-dependent precocious puberty treated with depot gonadotropin-releasing hormone analogs. J Clin Endocrinol Metab. 2008;93(7): 2662 doi:10.1210/jc.2007-2183 PMid:18460564
16. Moayeri H, Rabbani A. Frequency of different types of precocious puberty, determining the predisposing factor and need to treatment in children - Emam Hospital (1993-2000. Tehran Univ Med J. 2002; 60(2):124-30.
17. Qaemi N, Vakili R. Investigating the causes of precocious puberty in 55 girls referred to the Endocrine and Metabolism Clinic of Mashhad University of Medical Sciences. J Midwifery Infertil Women. 2000; 5(11):20-29
18. Moayeri H, Rahvarian M. A prospective study of height, age and bone age in children with precocious puberty -Imam Hospital (1993-2000). Tehran Univ Med J. 2002; 60(2): 131-8.
19. Leger J, Reynaud R, Czernichow P. Do all girls with apparent idiopathic precocious puberty require gonadotropin-releasing hormone agonist treatment? J Pediatr. 2000; 137(6): 819-25 doi:10.1067/mpd.2000.109201 PMid:11113839
20. Calcaterra V, Sampaolo P, Klersy C, Larizza D, Alfei A, Brizzi V, et al. Utility of breast ultrasonography in the diagnostic work-up of precocious puberty and proposal of a prognostic index for identifying girls with rapidly progressive central precocious puberty. Ultrasound Obstet Gynecol. 2009; 33(1): 85-91 doi:10.1002/uog.6271 PMid:19086040
21. Adan L, Chemaitilly W, Trivin C, Brauner R. Factors predicting adult height in girls with idiopathic central precocious puberty: implications for treatment. Clin Endocrinol. 2002; 56(3): 297-302 doi:10.1046/j.1365-2265.2002.01488.x PMid:11940040
22. Zung A, Burundukov E, Ulman M, Glaser T, Rosenberg M, Chen M, et al. The diagnostic value of first-voided urinary LH compared with GNRH-stimulated gonadotropins in differentiating slowly progressive from rapidly progressive precocious puberty in girls. Eur J Endocrinol. 2014;170(5): 749-58. doi:10.1530/EJE-14-0010 PMid:24536086
23. Giabicani E, Allali S, Durand A, Sommet J, Couto-Silva AC, Brauner R. Presentation of 493 Consecutive Girls with Idiopathic Central Precocious Puberty: A Single-Center Study. PLoS One. 2013; 8(7). doi:10.1371/journal.pone.0070931 PMid:23936254 PMCid:PMC3728106
24. Fontoura M, Brauner R, Prevot C, Rappaport R. Precocious puberty in girls: early diagnosis of a slowly progressing variant. Arch Dis Child 1989; 64 (8):1170-6 doi:10.1136/adc.64.8.1170 PMid:2782932 PMCid:PMC1792536
25. Lanes R, Soros A, Jakubowicz S. Accelerated versus slowly progressive forms of puberty in girls with precocious and early puberty. Gonadotropin suppressive effect and final height obtained with two different analogs. J Pediatric Endocrinol Metabol. 2004; 17(5): 759-66 doi:10.1515/JPEM.2004.17.5.759 PMid:15237711
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shiasi arani K, Enayati Arani S M, Gilasi H. Etiology and clinical features of precocious puberty in children referred to the endocrinology clinic of Kashan University of Medical Sciences, Iran. Feyz 2023; 27 (6) :696-702
URL: http://feyz.kaums.ac.ir/article-1-4774-en.html


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Volume 27, Issue 6 (Bimonthly 2023) Back to browse issues page
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