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:: Volume 27, Issue 1 (Bimonthly 2023) ::
Feyz 2023, 27(1): 1-11 Back to browse issues page
Investigating the effect of cytotoxicity of nanonisome containing the extract of Artemisia annua on breast cancer cell lines
Zahra Rastgar , Fariba Khosravinejad
Department of Biology, North Tehran Branch, Islamic Azad University, Tehran, I.R. Iran. , f.khosravinejad@iau-tnb.ac.ir
Abstract:   (993 Views)
Background: Niosomes are primary-bilayer vesicles used in anticancer drugs. The aim of this study is the synthesis of nisome nanocarrier containing Artemisia Annua extract and its anticancer charactersitics.
Materials and Methods: This in-vitro study was carried out at the Islamic Azad University, North Tehran Branch, from December 1400 to September 1401. Firstly, a niosomes nanocarrier was synthesized with the thin-layer hydration approach. Then, Artemisia Annua extract was loaded into them. Following that, physical and chemical features of nanocarriers were evaluated utilizing scanning electron microscope (SEM) and dynamic light scattering (DLS). The encapsulation level and the release pattern of the extract were valiadated vi a dialysis bag. Finally, its anticancer effects were investigated on breast cancer cell line (MCF_7).
Results: The results showed that the synthesized nanocarrier of nisome containing the extract has a spherical structure and its size was 208.1 nm and the encapsulation percentage was 62.35%. It was also found that the nanocarrier of loaded niosom had significant anticancer effects compared to non-loaded extract.
Conclusion: It can be concluded that the nisome-containing Artemisia Annua extract of medicinal plant increases the anti-cancer effects significantly, and therefore, nisome can be used as a targeted drug delivery system for anti-cancer purposes.
Keywords: Nanoprobe, Niosome, Artemisia Annua, Breast cancer
Full-Text [PDF 1910 kb]   (535 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2022/10/18 | Revised: 2023/07/25 | Accepted: 2023/02/13 | Published: 2023/04/5
1. Bunggulawa EJ, Wang W, Yin T, Wang N, Durkan C, Wang Y, et al. Recent advancements in the use of exosomes as drug delivery systems. J Nanobiotechnol 2018; 16(1): 1-13.
2. Khan I, Khan M, Umar MN, Oh D-H. Attenuation and production of the amphotericin B-resistant Leishmania tropica strain. Jundishapur J Microbiol 2016; 9(6).
3. Mirzaie A, Diba H, Khosravi-Nejad F, Javanmardi H. Synergistic cytotoxicity of bevacizumab and silver nanoparticles on ovarian cancer cell line (A2780) and analysis of Bcl-2 and caspase 3 apoptotic genes expression. J Cell Tissue 2021; 12(2): 72-87.
4. Patra JK, Das G, Fraceto LF, Campos EVR, Rodriguez-Torres MdP, Acosta-Torres LS, et al. Nano based drug delivery systems: recent developments and future prospects. J Nanobiotechnol 2018; 16(1): 1-33.
5. Yeo PL, Lim CL, Chye SM, Ling APK, Koh RY. Niosomes: a review of their structure, properties, methods of preparation, and medical applications. Asian Biomedicine 2017; 11(4): 301-14.
6. Osanloo M, Assadpour S, Mehravaran A, Abastabar M, Akhtari J. Niosome-loaded antifungal drugs as an effective nanocarrier system: A mini review. Curr Med Mycol 2018; 4(4): 31.
7. Qamar Z, Qizilbash FF, Iqubal MK, Ali A, Narang JK, Ali J, et al. Nano-based drug delivery system: recent strategies for the treatment of ocular disease and future perspective. Recent Pat Drug Deliv Formul 2019; 13(4): 246-54.
8. Paolino D, Muzzalupo R, Ricciardi A, Celia C, Picci N, Fresta M. In vitro and in vivo evaluation of Bola-surfactant containing niosomes for transdermal delivery. Biomed Microdevices 2007; 9(4): 421-33.
9. Raju SR, Balakrishnan S, Kollimada S, Chandrashekara K, Jampani A. Anti-tumor effects of Artemisia nilagirica extract on MDA-MB-231 breast cancer cells: Deciphering the biochemical and biomechanical properties via TGF-β upregulation. Heliyon 2020; 6(10): e05088.
10. Akbarzadeh I, Shayan M, Bourbour M, Moghtaderi M, Noorbazargan H, Eshrati Yeganeh F, et al. Preparation, optimization and in-vitro evaluation of curcumin-loaded niosome@ calcium alginate nanocarrier as a new approach for breast cancer treatment. Biology 2021; 10(3): 173.
11. Yan L, Xiong C, Xu P, Zhu J, Yang Z, Ren H, et al. Structural characterization and in vitro antitumor activity of A polysaccharide from Artemisia annua L.(Huang Huahao). Carbohydrate Polymers 2019; 213: 361-9.
12. Teimouri M, Khosravinejad F. Inhibitory effects of Behind the scenes medicine extract (Physalis alkekengi) on prostate cancer caused by DMBA injection in mice. Develo Biol 2021; 13(2): 31-8.
13. Lang SJ, Schmiech M, Hafner S, Paetz C, Steinborn C, Huber R, et al. Antitumor activity of an Artemisia annua herbal preparation and identification of active ingredients. Phytomednei. 2019; 62: 152962.
14. Charlie-Silva I, Fraceto LF, de Melo NFS. Progress in nano-drug delivery of artemisinin and its derivatives: towards to use in immunomodulatory approaches. Artif Cells Nanomed Biotechnol 2018; 46(Sup3): S611-S20.
15. Meng Y, Ma N, Lyu H, Wong YK, Zhang X, Zhu Y, et al. Recent pharmacological advances in the repurposing of artemisinin drugs. Med Res Reviews 2021; 41(6): 3156-81.
16. Ekiert H, Świątkowska J, Klin P, Rzepiela A, Szopa A. Artemisia annua–Importance in Traditional Medicine and Current State of Knowledge on the Chemistry, Biological Activity and Possible Applications. Planta Med 2021; 87(08): 584-99.
17. Taleghani A, Emami SA, Tayarani-Najaran Z. Artemisia: a promising plant for the treatment of cancer. Bioorganic Med Chem 2020; 28(1): 115180.
18. Rashidian S, Bagheri KA, Mirzaie A. Antibacterial and anticancer activities of biosynthesized silver nanoparticles using Artemisia khorassanica extract: Bax and Bcl2 apoptosis gene expression analysis. 2019.
19. Taebpour M, Majdizadeh M, Haghiralsadat BF. Fabrication and characterization of liposomal nanoparticles containing hydroalcoholic extract of Artemisia absintium and its toxicity on MCF-7 breast cancer cell line. IQ J Breast Dis 2021; 14(1): 64-77.
20. Moalemzadeh S, Rajabbeigi E, Montazeri M. Investigation on cytotoxic effect of hydroalcoholic extract of Artemisia sieberi on SKBr3cell line. J Cell Tissue 2019; 10(4): 252-60.
21. Sofalian O, Zare N, Latifi S, Hasanpour K, Motalebinia S. Evaluation of anticancer effect of Mentha longifolia and Artemisia persica hydro-alcoholic extracts against human gastric cancer cells (AGS). Genetic Engineering Biosafety J 2020; 9(1): 1-10.
22. Tabatabaei Yf, Alizadeh Bb, Alghooneh A, Zanganeh H. Optimization Of Extraction Of Mespilus Germanica By Mixture Design And Investigation Of Its Effect On Infectious Microorganisms “In Vitro”. 2016.
23. Sahab-Negah S, Ariakia F, Jalili-Nik M, Afshari AR, Salehi S, Samini F, et al. Curcumin loaded in niosomal nanoparticles improved the anti-tumor effects of free curcumin on glioblastoma stem-like cells: an in vitro study. M Neurobiol 2020; 57(8): 3391-411.
24. Wichayapreechar P, Anuchapreeda S, Phongpradist R, Rungseevijitprapa W, Ampasavate C. Dermal targeting of Centella asiatica extract using hyaluronic acid surface modified niosomes. J Liposome Res 2020; 30(2): 197-207.
25. Buttacavoli M, Albanese NN, Di Cara G, Alduina R, Faleri C, Gallo M, et al. Anticancer activity of biogenerated silver nanoparticles: an integrated proteomic investigation. Oncotarget 2018; 9(11): 9685.
26. Askari M, Nikoonahad Lotfabadi N. Evaluation of niosomal nano-carriers capabilities on toxicity preservation and delivery of pomegranate peel extract in cell culture conditions (MCF-7 cell line of breast cancer). D Med 2020; 26(5): 9-20.
27. Montané X, Bajek A, Roszkowski K, Montornés JM, Giamberini M, Roszkowski S, et al. Encapsulation for cancer therapy. Molecules 2020; 25(7): 1605.
28. Bhardwaj P, Tripathi P, Gupta R, Pandey S. Niosomes: A review on niosomal research in the last decade. J Drug Deli Sci Technol 2020; 56: 101581.
29. Obeid MA, Gany SAS, Gray AI, Young L, Igoli JO, Ferro VA. Niosome-encapsulated balanocarpol: compound isolation, characterisation, and cytotoxicity evaluation against human breast and ovarian cancer cell lines. Nanotechnol 2020; 31(19): 195101.
30. Barani M, Mirzaei M, Torkzadeh-Mahani M, Nematollahi MH. Lawsone-loaded Niosome and its antitumor activity in MCF-7 breast Cancer cell line: a Nano-herbal treatment for Cancer. DARU J Pharma Sci 2018; 26(1): 11-7.
31. Baranei M, Taheri RA, Tirgar M, Saeidi A, Oroojalian F, Uzun L, et al. Anticancer effect of green tea extract (GTE)-Loaded pH-responsive niosome Coated with PEG against different cell lines. Materials Today Communications 2021; 26: 101751.
32. Hajizadeh MR, Parvaz N, Barani M, Khoshdel A, Fahmidehkar MA, Mahmoodi M, et al. Diosgenin-loaded niosome as an effective phytochemical nanocarrier: Physicochemical characterization, loading efficiency, and cytotoxicity assay. DARU J Pharma Sci 2019; 27(1): 329-39.
33. Sharma P, Saxena P, Jaswanth A, Chalamaiah M, Tekade K, Balasubramaniam A. Novel encapsulation of lycopene in niosomes and assessment of its anticancer activity. J Bioe Bioavaila 2016; 8(5): 224-32.
34. Dabaghian Amiri A, Mirzaie A, Ali Asgari E, Mahmoudzadeh A. Preparation of niosome loaded Artemisia chamamelifolia extract: antibacterial and anti-cancer activities and apoptosis gene expression analysis in breast cancer cell line (MCF-7). Feyz 2021; 25(2): 839-49. [in Persian]
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Rastgar Z, Khosravinejad F. Investigating the effect of cytotoxicity of nanonisome containing the extract of Artemisia annua on breast cancer cell lines. Feyz 2023; 27 (1) :1-11
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Volume 27, Issue 1 (Bimonthly 2023) Back to browse issues page
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