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The Effect of High Fat Diet and Continous Endurance Training on Expression of TFEB and E2F1 Transcription Factors on Visceral Adipose Tissue of Mice
Saeed Daneshyar * , Zahra Mirakhori , Yazdan Forutan
University of Ayatollah Alozma Boroujerdi , s.daneshyar@abru.ac.ir
Abstract:   (168 Views)
Background and Aim. Transcription Factor EB (TFEB) and Transcription Factor E2F1 play an important role in metabolism, and their levels have been reported to be increased by High Fat Diets. The present study aimed to survey the effect of exercise training (Continous Endurance Training) on gene expression of these genes in visceral adipose tissue of mice fed a high-fat diet.
Materials and Methods. In the experimental study, 28 male mice (C57BL/6) were assigned into four groups included Control, High-Fat Diet (HFD), Exercise Training (ET), and High-Fat Diet with Exercise Training (HFD-ET)The subjects of HFD were fed a high-fat diet for 12 weeks. The mice of ET performed continuous endurance training on a treadmill for six weeks. The mice of HFD-ET had six weeks of endurance training in addition to having the HFD. The Real-Time–PCR methods were used to measure the gene expression of TFEB and E2F1.
Results. The results were the following: 1) the gene expression of TFEB was increased by HFD and ET (p<0.05), 2) The combination of HFD and ET had an increasing effect on TFEB (p=0.02), However, the combined effect was not higher than ET and HFD separately (p>0.05), 3) HFD caused an increase in E2F1 (p=0.03), and 4) Neither ET nor combined HFD and ET significantly increased the expression of E2F1 (p>0.05).
Conclusion. The results indicated that continuous endurance training has a similar effect (and no opposite effect) to the high-fat diet on gene expression of TFEB. Further, based on results it could be thought that the exercise training may partly negate the increasing effect of the high-fat diet on E2F1 expression.  

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Keywords: High Fat Diet, Exercise Training, Endurance Training, Adipose Tissue, TEFB, E2F1
Type of Study: Research | Subject: medicine, paraclinic
Received: 2022/08/4 | Accepted: 2022/11/7
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