History and Objectives: Hirsutism after goiter is the most common etiology for women’s reference to specialized clinics in our country. Due to symptomatic treatment and various reports of possible effects of adrenal dysfunction on the creation of hirsutism, the present investigation was carried out on patients referred to Tarbiat Modarres University Clinic in 1992-1993.

Materials and Methods: A case control study was designed. The case group was consisted of 38 hirsute women with score of hirsutism greater than 5 based on Ferriman-Galway Pathway, clinical and paraclinical assessment and adrenal dysfunction. Control group was consisted of 31 healthy individuals without hirsutism. Information concerning interview of individuals, clinical and paraclinical hormonal assessment and adrenal dysfunction were recorded for the two groups. Chi-square statistical analysis was performed.

Results: From total of 38 patients in the case group, 21.5% were suffering from adrenal dysfunction or adrenal-ovarian dysfunction and positive relationship was recorded between adrenal dysfunction and hirsutism.

Conclusion: Adrenal abnormalities are cause of hirsutism among patients examined. For proper treatment of hirsutism, those addressing the adrenal complications ought to be of prime concern and for those referred to the outpatient clinics, laboratory assessment of adrenal dysfunction is suggested.