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:: Volume 26, Issue 6 (Bimonthly 2022) ::
Feyz 2022, 26(6): 637-645 Back to browse issues page
Investigating the expression of Toll-like receptor 4- Myeloid differentiation primary response 88 pathway after a period of exercise and vitamin E consumption in endometriosis model rats
Soheila Heydarzai , Lida Moradi , Parvin Farzanegi , Bahram Abedi
Department of Exercise Physiology, Faculty of Physical Education, Islamic Azad University, Tehran North Branch, Tehran, I.R. Iran. , Moradi.lida@gmail.com
Abstract:   (975 Views)

Background: Endometriosis is a chronic, inflammatory and estrogen-dependent disease characterized by the growth of endometrial tissue outside the uterine cavity. The responses of the immune system, nutrition, sports activity are among the most important factors affecting this disease. The research aimed to investigating the expression of TLR4 and MyD88 pathway after a period of exercise and vitamin E consumption in endometriosis model rats.

Materials and Methods: The research is of fundamental and experimental type. 25 female Wistar rats were selected and divided into 5 different groups. After induction of endometriosis, rats in the training group swam 5 days a week. The vitamin E consumption group consumed the supplement daily. The studied proteins included TLR4 and MyD88. One-way analysis of variance and Bonferroni's post hoc test were used at the significance level of P≤0.05.

Results: There was a significant difference between the research groups. The results of Bonferroni post hoc test showed that the expression level of MyD88 gene in healthy control group differed from endometriosis model control groups (P=0.0001), exercise group (P=0.019) and patient control group+vitamin E supplement (P=0.021). Significantly, the control group of endometriosis model was significantly different from the exercise group (P=0.002), the patient control group+vitamin E supplement (P=0.002) and the patient group+vitamin E+exercise (P=0.0001). There was a significant difference in the expression of TLR4 gene in the healthy control group with the control group of endometriosis model (P=0.048).

Conclusion: Induction of endometriosis strongly affects this pathway to cause inflammation in the tissue. Exercise with enzymatic adaptations may help slow the pathway and prevent inflammation and tissue cell proliferation down.

Keywords: Endometriosis, Exercise, Vitamin E, Toll-like receptor 4, Myeloid differentiation primary response gene 88 protein
Full-Text [PDF 449 kb]   (466 Downloads)    
Type of Study: Research | Subject: General
Received: 2022/07/8 | Revised: 2023/03/15 | Accepted: 2022/12/6 | Published: 2023/02/22
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Heydarzai S, Moradi L, Farzanegi P, Abedi B. Investigating the expression of Toll-like receptor 4- Myeloid differentiation primary response 88 pathway after a period of exercise and vitamin E consumption in endometriosis model rats. Feyz 2022; 26 (6) :637-645
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Volume 26, Issue 6 (Bimonthly 2022) Back to browse issues page
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