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:: Volume 26, Issue 1 (Bimonthly 2022) ::
Feyz 2022, 26(1): 22-29 Back to browse issues page
The effect of resistance training with liposomal vitamin C on UCP1 and FIS1 expression in hepatocytes of elderly rats
Mostafa Khodabandeh , Maghsoud Peeri * , Mohammad Ali Azarbayjani , Hassan Matinhomaee
Department of Sports Physiology, Faculty of Physical Education and Sports Sciences, Central Tehran Branch, Islamic Azad University, Tehran, I.R. Iran. , m.peeri@gmail.com
Abstract:   (225 Views)
Background: Aging can increase the risks of various liver diseases and act as an unfavorable prognostic factor and increase mortality. Therefore, this study aimed to investigate the effect of 8-week resistance training with liposomal vitamin C on the expression of UCP1 and FIS1 in hepatocytes of elderly rats.
Material and Methods: The present study was an experimental study with a control group. Twenty-five male rats (Wistar) aged 24 weeks (280-320 g) were randomly divided into 5 groups; young control group, elderly + resistance training group, elderly + liposomal vitamin C group, elderly + resistance training + liposomal vitamin C group and old age control group. In the groups receiving liposomal vitamin C, liposomal vitamin C was administered daily based on kilograms of body weight.
Results: UCP1 expression was significantly reduced in the elderly group compared to the young group (P=0.001). However, the expression of UCP1 in the elderly group + resistance training along with vitamin C consumption increased significantly compared to the elderly group (P=0.001). Also, FIS1 expression was significantly increased in the elderly group compared to the young group (P=0.001). However, the expression of FIS1 in the elderly group + resistance training with vitamin C consumption was significantly reduced compared to the young group (P=0.001).
Results: Aging increases FIS1 expression and decreases UCP1 expression in rat liver tissue. However, resistance training with vitamin C decreases FIS1 expression and increases UCP1 expression in elderly rats.
Keywords: Resistance training, Vitamin C, UCP, FIS1
Full-Text [PDF 531 kb]   (95 Downloads)    
Type of Study: Research | Subject: General
Received: 2021/11/17 | Accepted: 2022/02/14 | Published: 2022/04/4
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Khodabandeh M, Peeri M, Azarbayjani M A, Matinhomaee H. The effect of resistance training with liposomal vitamin C on UCP1 and FIS1 expression in hepatocytes of elderly rats. Feyz. 2022; 26 (1) :22-29
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