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:: Volume 23, Issue 3 (Bimonthly 2019) ::
Feyz 2019, 23(3): 318-333 Back to browse issues page
Genetic etiology of Asthenozoospermia: A review
Arvand Akbari , Zahra Anvar , Mojtaba Jaafarinia , Mehdi Totonchi *
Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, I. R. Iran. , m.totonchi@royaninstitute.org
Abstract:   (3635 Views)
Background: Asthenozoospermia, as the most prevalent cause of male infertility, is defined as low percentage of progressively motile spermatozoa per ejaculate. It occurs in both non-syndromic and syndromic forms and later it manifests as a part of primary ciliary dyskinesia. In the last decade, with the advent of Next-generation sequencing technologies numerous genes have been introduced in the pathogenesis of different diseases. Here, we review the genes implicated in asthenozoospermia by genetic studies.
Materials and Methods: Strategies employed by infertility genetics studies in original research articles extracted from PubMed database are critically reviewed. Afterwards, genes implicated in asthenozoospermia and primary ciliary dyskinesia are discussed.
Results: Until today, pathogenic variants in DNAH1, SEPT12, SLC26A8, CATSPER1, CATSPER2 and ADCY10 have been reported to cause non-syndromic asthenozoospermia. Moreover, DNAI1, DNAH5, DNAAF2, CCDC39, DYC1X1 and LRRC6 have been implicated in primary ciliary dyskinesia and syndromic asthenozoospermia.
Conclusion: Next-generation sequencing technologies and especially whole-exome sequencing in families with multiple asthenozoospermic patients showed considerable success in introduction of genes involved in asthenozoospermia leading to a more comprehensive knowledge on genetics of infertility.
Keywords: Asthenozoospermia, Primary ciliary dyskinesia, Next-generation sequencing, Whole-exome sequencing
Full-Text [PDF 527 kb]   (2862 Downloads)    
Type of Study: Review | Subject: General
Received: 2019/01/15 | Revised: 2019/08/18 | Accepted: 2019/04/15 | Published: 2019/07/31
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Akbari A, Anvar Z, Jaafarinia M, Totonchi M. Genetic etiology of Asthenozoospermia: A review. Feyz 2019; 23 (3) :318-333
URL: http://feyz.kaums.ac.ir/article-1-3790-en.html

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